Publications by authors named "Jun Zha"

Article Synopsis
  • The study investigates how T follicular helper cells and the cytokine IL-21 contribute to hypoxia-induced pulmonary hypertension (HPH), a condition that can lead to serious heart problems.
  • Using mouse models, the research found that mice lacking IL-21 or with reduced T cells showed less severe pulmonary hypertension, suggesting that IL-21 plays a crucial role in the disease's progression.
  • The findings revealed that chronic exposure to hypoxia increases germinal center B cell activity and promotes a shift in macrophages towards a phenotype that exacerbates vascular remodeling, showcasing potential targets for future therapies.
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This study aimed to explore the underlying mechanism of nebulized dexmedetomidine (DEX) in ameliorating ventilator-induced lung injury (VILI)-induced oxidative stress in rats. Forty 7 to 8-week-old Sprague-Dawley rats at the specific pathogen-free level were randomized into the control group, model group, nebulized dexmedetomidine (WH-YM) group, and dexmedetomidine intravenous infusion (JM-YM) group, each containing 10 rats. Except for the control group, rats in the other groups underwent mechanical ventilation (tidal volume,  40 mL/kg; respiratory rate, 70 breaths per minute; inspiratory-to-expiratory ratio, 1:2; fraction of inspired oxygen, 21%; positive end-expiratory pressure, 0 cmH2O).

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Background: Postpartum posttraumatic stress disorder (PTSD) can occur in women who give birth after emergency admission. The identification of risk factors for this condition is crucial for developing effective preventive measures. This retrospective study aimed to explore the incidence and risk factors for postpartum PTSD in women who give birth after emergency admission.

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Myocardial fibrosis is the characteristic pathology of diabetes-induced cardiomyopathy. Therefore, an in-depth study of cardiac heterogeneity and cell-to-cell interactions can help elucidate the pathogenesis of diabetic myocardial fibrosis and identify treatment targets for the treatment of this disease. In this study, we investigated intercellular communication drivers of myocardial fibrosis in mouse heart with high-fat-diet/streptozotocin-induced diabetes at single-cell resolution.

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It is significant but challenging to understand the property evolution of metal nanoclusters by orientated regulation of the electronic structure. Previous research has demonstrated that the optical properties of metal nanoclusters with anisotropic structures are greatly impacted by their longitudinal electronic structure. However, the manipulation of optical properties of metal nanoclusters by regulating their electronic structure through longitudinal dithiolate substitutions has not yet been reported.

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Article Synopsis
  • The study investigates how different rolling processes (room-temperature, cryogenic, and deep cryogenic treatment) and aging affect the microstructure and mechanical properties of a Cu-1.0Cr-0.1Zr alloy.
  • Cryogenic rolling (CR) enhances the formation of the Cr phase and achieves greater grain fragmentation compared to room-temperature methods, leading to improved tensile strength and hardness.
  • The research also reveals that wear mechanisms vary, with adhesive wear dominating early stages and abrasive wear in later stages, while CR significantly boosts wear resistance compared to other treatments.
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Microplastics (MPs) are able to interact with diverse contaminants in sediments. However, the impacts of MPs on sediment properties and bacterial community structure in heavy metal-contaminated sediments remain unclear. In this study, we investigated the adsorption of Pb(II) by sediment-MPs mixtures and the effects of different concentration MPs on sediment enzyme activities, DOM fractions, and Pb bioavailability in riverine sediments, and further explored the response of sediment microbial community to Pb in the presence of MPs.

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Surface atom replacement in materials without other composition/structure changes is challenging but is important for fundamental scientific research and for practical applications. In particular, for nanoparticles including nanoclusters, surface metal site-specific replacement with atomic precision has not yet been achieved. In this study, we for the first time achieved surface site-specific antigalvanic replacement with the remaining composition/structure and surface replacement-dependent selectivity in the electrocatalytic reduction of CO.

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Nanoparticle assembly paves the way for unanticipated properties and applications from the nanoscale to the macroscopic world. However, the study of such material systems is greatly inhibited due to the obscure compositions and structures of nanoparticles (especially the surface structures). The assembly of atomically precise nanoparticles is challenging, and such an assembly of nanoparticles with metal core sizes strictly larger than 1 nm has not been achieved yet.

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Ischemic stroke is a clinical syndrome caused by the disruption of blood flow into cerebral tissues and is associated with high disability and mortality rates. Studies have established the pathological role of platelets in cerebral ischemia/reperfusion (I/R) injury, although the underlying mechanism of action remains largely unclear. In this study, we created an I/R mouse model via middle cerebral artery occlusion and reperfusion (MCAO/R) and analyzed the transcriptomic profiles of the ipsilateral and contralateral cortices using RNA-seq.

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Background: Pulmonary hypertension (PH) is a progressive disorder lacking a validated and effective therapy which characterized by elevated pulmonary arterial pressure, vascular remodeling and eventual death. FDA approved sildenafil is being used as a first-line drug for PH, however, neither survival rates nor quality of life have been improved because of side effects and patient noncompliance. Thus, the exploration of novel therapeutic drugs is urgently needed.

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Objective: Elderly patients with hip surgery are prone to postoperative cognitive dysfunction (POCD), leading to health management difficulties. This study is aimed at investigating the effect of ultrasound radiomics-guided iliac fascia block on POCD.

Methods: A total of 67 cases of patients who had undergone hip joint surgery were divided into a training set ( = 47) and a validation set (radiomics-guided group, = 20).

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Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role of the RIPK1/RIPK3 signaling pathway in myocardial fibrosis and related diabetic cardiomyopathy is still unclear. We hypothesized that RIPK1/RIPK3 activation mediated myocardial fibrosis by impairing the autophagic flux.

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Natural disulfide-rich peptides (DRPs) are valuable scaffolds for the development of new bioactive molecules and therapeutics. However, there are only a limited number of topologically distinct DRP folds in nature, and most of them suffer from the problem of oxidative folding. Thus, strategies to design DRPs with new constrained topologies beyond the scope of natural folds are desired.

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We present a method for atomically precise nanocluster synthesis. As an illustration, we introduced the reducing-ligand induction combined method and synthesized a novel nanocluster, which was determined to be Au (SCH Ph- Bu) with the same number of gold atoms as existing Au (SR) nanoclusters but different ligands (hetero-composition-homo-size). Compared with the latter, the former has distinct properties and structures.

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Periodontitis is a chronic inflammatory oral disease that affects almost half of the adult population. NF-κB activator 1 (Act1) is mainly expressed in immune cells, including macrophages, and modulates immune cells' function to regulate inflammation in inflammatory diseases. Macrophages play a vital role in the pathophysiology of periodontitis.

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Article Synopsis
  • Researchers synthesized a new type of thiolated gold nanocluster (Au(SR)) and successfully determined its structure using single crystal X-ray crystallography (SCXC).
  • This unique structure consists of an unconventional gold (Au) core surrounded by both one and fifteen staples, allowing it to thermally aggregate into larger nanoparticles.
  • The resulting gold nanoparticle film shows excellent sensitivity and uniformity as a surface-enhanced Raman scattering (SERS) substrate, making it useful for detecting various organic pollutants.
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Objective: To reveal the effects and related mechanism of cisatracurium on colorectal cancer (CRC) development.

Methods: HCT116 and SW480 cells were treated with various concentrations of cisatracurium or transforming growth factor-β (TGF-β). Chemokine C-X-C-Motif Receptor 4 (CXCR4) was overexpressed and let-7a-5p was silenced in cells by transfection with pcDNA3.

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The processing of high-precision aerospace parts requires not only ultra-precision machine tools, but also high-efficiency processing. However, in order to realize high-efficiency processing, besides optimizing the system and process parameters, some subversive research can also be done on the machine tool structure. In this paper, the lightweight research is mainly carried out on the structure of machine tool worktable.

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Improving the cutting efficiency is the major factor for improving the processing of nickel-based alloys. The novelty of this research is the calibrated SiAlON ceramic tool dry milling nickel-based alloy process. Firstly, the nickel-based alloy dry milling process was analyzed through the finite element method, and the required milling force and temperature were deduced.

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Deformation of thin-walled titanium alloys can occur during the milling process due to the cutting force and chatter vibration, which can influence the precision of the finished parts. In this research, a new milling method without auxiliary support for machining of thin-walled parts was proposed. A large cutting depth and layered milling technology were used during rough machining, with a different machining allowance for each subsequent remaining layer.

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This study proposes two path generation algorithms to diminish the superposition of the convolution effect on the polishing path in computer-controlled optical surfacing. According to the polishing of aluminum-alloy based hyperboloid optical components, different proportions of polishing agents were blended. Then, the surface roughness of the optical components were determined through a validation experiment of the algorithms.

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MicroRNAs (miRNAs/miRs) are small non‑coding RNAs that can act as oncogenes or tumor‑suppressor genes in human cancer. Previous studies have revealed that abnormal expression of miRNAs is closely associated with tumor cell cycle, differentiation, growth and apoptosis. miR‑543 is expressed abnormally in a wide variety of cancers and has been associated with cellular proliferation, apoptosis, and invasion; however, the effect of miR‑543 remains unknown in oral squamous cell carcinoma (OSCC).

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