Publications by authors named "Jun Ying He"
Spontaneous intracranial hypotension (SIH) may lead to cerebral venous thrombosis (CVT). This case report describes the diagnostic and treatment processes used for a patient with CVT caused by SIH due to spontaneous spinal cerebrospinal fluid (CSF) leakage in the high cervical region. Clinical data were collected from a 37-year-old man with an initial symptom of spontaneous posterior cervical pain.
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- Diffuse midline gliomas, H3 K27-altered are a type of brain tumor commonly found in children, characterized by specific genetic mutations and a generally poor prognosis.
- An adult patient exhibited symptoms that mimicked a central nervous system infection, leading to an initial misdiagnosis of meningitis, despite treatment not improving their condition.
- After further imaging, the tumor was identified, and the patient received chemotherapy, resulting in a temporary improvement in their health, highlighting the challenges in diagnosing this type of glioma and the importance of thorough assessment.
Primary aldosteronism (PA) is a disease characterized by hypertension and hypokalemia due to the excessive aldosterone secretion from the adrenal cortex, which leads to the retention of both water and sodium, and the inhibition of the renin-angiotensin system as well. Familial hyperaldosteronism type II (FH-II) is known as an autosomal dominant hereditary disease, which is a scarce cause of PA. In this report, we cllected the clinical data of a patient with repeated hypertension and hypokalemia of uncertain diagnosis since 2014.
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- A 42-year-old man developed severe visual impairment during hospitalization for PRV encephalitis, and he received aggressive antiviral treatment with ganciclovir and sodium foscarnet for over 50 days.
- This case highlights the potential for partial recovery of vision after intensive treatment, emphasizing the importance of timely antiviral and anti-inflammatory therapy to reduce ocular complications from PRV.
Article Synopsis
- - The study analyzed somatic gene mutations and copy number variations (CNVs) in cerebrospinal fluid (CSF) ctDNA from 58 patients with neoplastic meningitis (NM) using next-generation sequencing and bioinformatics.
- - The most frequently mutated gene was TP53 (87.10%), with other notable mutations including EGFR (70.97%) and PTEN (62.90%), showing a predominance in the PI3K-Akt signaling pathway.
- - Findings suggest that these mutated genes could serve as potential biomarkers for diagnosing NM and might influence meningeal metastasis through specific signaling pathways.
Background: Meningeal carcinomatosis (MC) is the most severe form of brain metastasis and causes significant morbidity and mortality. Currently, the diagnosis of MC is routinely confirmed on the basis of clinical manifestation, positive cerebrospinal fluid (CSF) cytology, and/or neuroimaging features. However, negative rate of CSF cytology and neuroimaging findings often result in a failure to diagnose MC from the patients who actually have the disease.
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- Researchers created carbon nanofibers by combining Co-containing zeolitic imidazolate frameworks (ZIF-67) with natural eggshell membranes (ESMs).
- These nanofibers demonstrated outstanding oxygen reduction reaction (ORR) performance due to their hierarchical structure and the presence of cobalt and nitrogen.
- The process not only produced efficient materials but also contributed to environmental sustainability by reusing waste from eggshell membranes.
A series of Zr-based metal-organic framework (MOF) composites embedded with three kinds of aptamer strands (509-MOF@Apt) were achieved by a one-step de novo synthetic approach. A platform for ultrasensitive detection of analytes, namely, thrombin, kanamycin, and carcinoembryonic antigen (CEA), was also established. Considering the conformational changes caused by the binding interactions between aptamer strands and targeted molecules, the label-free electrochemical aptasensors based on 509-MOF@Apt composites could be developed to detect various target molecules.
View Article and Find Full Text PDFCCL1, one of the members of the CC chemokine family, is an inflammatory mediator that stimulates the migration of human monocytes. CCL1 expression is induced by Mycobacterium tuberculosis and TLR ligands in macrophage. TLR2 plays critical role in host immune response against M.
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