Publications by authors named "Jun Yeup Seong"
Article Synopsis
- The study explored how skin microbiota is crucial for skin health and how disturbances can lead to harmful microorganisms, aiming to create a red ginseng formulation that promotes good bacteria.
- Methods involved testing the formulation’s effects on bacterial growth, combining it with preservatives, and conducting a clinical trial with 20 female subjects to assess changes in their skin microbiome.
- Results showed that the red ginseng formulation improved the growth of beneficial bacteria while reducing overall microbial diversity, indicating its potential for maintaining healthy skin microbiome.
Stem cell transplantation can induce neovascularization. Regenerated blood vessels should remain stable for a long-term period in order to function as new blood vessels in ischemic tissues. Here we show that local delivery of FGF2 enhances the long-term (12weeks) angiogenic efficacy of human adipose-derived stem cells (hADSCs) implanted into mouse ischemic hindlimbs.
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- - This study investigates how combining transforming growth factor-beta3 (TGF-β3) and hyaluronic acid (HA) affects the chondrogenic differentiation of human mesenchymal stem cells (hMSCs).
- - hMSCs were grown on different surfaces, and after four weeks, various cartilage-specific markers were analyzed to assess differentiation.
- - Results indicated that using HA-coated dishes along with TGF-β3 led to a significant increase in key cartilage markers, suggesting that both the cell-adhesion surface and the growth factor work together to enhance stem cell differentiation.
Implantation of chondrocytes isolated from patients and expanded in number in vitro is being used to treat patients with cartilage injuries. However, chondrocytes de-differentiate during culture with several passages, and cartilage regenerated by implantation of de-differentiated chondrocytes may be suboptimal. Here, we show that a spinner-flask culture system induces formation of chondrocyte aggregates and redifferentiate de-differentiated chondrocytes.
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