Publications by authors named "Jun Yeol Kim"
Savolitinib is a highly selective small molecule inhibitor of the mesenchymal epithelial transition factor (MET) tyrosine kinase, primarily developed for the treatment of non-small cell lung cancer (NSCLC) with mutations. It is also being investigated as a treatment for breast, head and neck, colorectal, gastric, pancreatic, and other gastrointestinal cancers. In both preclinical and clinical studies, it has demonstrated efficacy in lung, kidney, and stomach cancers.
View Article and Find Full Text PDFWe present the physics of sequential dewetting phenomenon and continuous fabrication of a polymeric microstencil using dewetting phenomenon with roll-to-roll imprinting equipment. To realize dewetting-assisted residual-free imprinting, mold material, polymer resin, and substrate were selected via interfacial surface energy analysis. In addition, optimal parameters of the continuous process were also studied by experimentally comparing the resultant shape of the microstencil depending on the process speed, aspect ratio of the mold, and applied pressure.
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- Recent studies indicate that HIF-2α plays a critical role in the destruction of cartilage in osteoarthritis, but its specific impact on the inflammatory response and osteoclast differentiation is not fully understood.
- This research shows that HIF-2α is enhanced in inflamed periodontal ligament cells from periodontitis patients and responds positively to stimuli like nicotine and lipopolysaccharide (LPS), leading to increased inflammatory markers and tissue degradation enzymes.
- Inhibiting HIF-2α reduced inflammatory responses and osteoclast formation in these cells, suggesting that targeting HIF-2α could offer new treatment options for conditions like periodontitis.
Article Synopsis
- Mollugin, a phytochemical from the Rubia cordifolia plant, has been shown to induce cell death in oral cancer cells (OSCCs) by promoting apoptosis, but its effects had not been previously documented for oral cancer specifically.
- The study found that mollugin disrupts the NF-κB signaling pathway, reducing levels of anti-apoptotic and invasive factors, and enhances the activity of cellular stress response pathways involving p38, ERK, and JNK.
- Ultimately, the research suggests that mollugin could be a potential chemotherapeutic agent for oral squamous cell carcinoma by activating protective pathways (HO-1 and Nrf2) while inhibiting harmful ones (NF-κB).
When elucidating the potential fate and bioavailability of nanomaterials (NMs) in an aquatic system, it is important to consider the interactions between NMs and natural organic matter (NOM). The present study compared the toxicities of carbon-based NMs, with disparate physicochemical properties, on Japanese medaka (Oryzias latipes) embryos after the addition of NOM. The measured embryonic toxicity parameters were mortality, malformation and hatching delay.
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- Different preparation methods for fullerene water suspensions (nC(60))—toluene exchange, DMSO dissolving, and stirring—result in varying physicochemical properties and toxicity levels.
- The Tol/nC(60) showed small, spherical aggregates, while DMSO/nC(60) and Aqu/nC(60) had larger mesoscale aggregates.
- The toxicity of these suspensions to Japanese medaka embryos ranked from highest to lowest as Tol/nC(60), DMSO/nC(60), and Aqu/nC(60), with specific effects like mortality and malformations linked to their respective structures and remaining solvents.