Dynamic culture system advances the applications of breast cancer organoids for precision medicine.

Tumor organoid-based drug sensitivity prediction is a new approach for precision medicine, which has wide applications in cancer treatment and attracts increasing attention. In the field of breast cancer, conventional organoid culture methods often require more than three weeks of culture period. The culture time greatly limits the further extension of the application scenarios of breast cancer organoids.

Atom interferometry in a blue-detuned guiding optical potential.

We propose and demonstrate a novel, to the best of our knowledge, scheme for atom interferometry along the direction deviating an angle from gravity, using slender light pulses that nest around a blue-detuned guiding optical potential (BDGOP). Cold atoms could be uniformly transported through guiding optical potential and interacted coherently by slender light pulses. We analyze the coherence of cold atoms in BDGOP using the Ramsey interference.

Predictive Observer-Based Dual-Rate Prescribed Performance Control for Visual Servoing of Robot Manipulators With View Constraints.

This article simultaneously addresses the dual-rate and view constraints issues for the image-based visual servoing (IBVS) system of robot manipulators. Considering the low sampling bandwidth of the camera, potentially diminishing the efficiency of the robotic controller in updating low-level servoing control commands, a predictive observer (PO) is initially designed to forecast the system output during the high-level sampling intervals. Moreover, by leveraging a mixture of soft-sensing and real-measured signals, a dual-rate integral-based prescribed performance control (DRIPPC) approach is devised.

Effects of Holothuria leucospilota polysaccharide on alleviating diabetic kidney disease through regulating inflammation.

Diabetic kidney disease (DKD) is a severe metabolic disorder that typically results from diabetes mellitus and culminates in chronic kidney disease and renal failure. It has been reported that Holothuria leucospilota polysaccharide (HLP) has an improvement effect on type 2 diabetes mellitus (T2DM) rats. This study aimed to explore the impact of HLP on DKD further and reveal its mechanism.

Anion-Regulated Solvation Structure and Electrode Interface toward Rechargeable Magnesium Batteries.

Developing chlorine-free electrolytes enabling fast Mg transport through a solid/cathode-electrolyte interphase (SEI/CEI) remains critical for rechargeable magnesium batteries (RMBs). However, single-anion electrolytes often lack the necessary redox properties for this requirement. Here, we propose a dual-anion electrolyte combining magnesium bis(trifluoromethanesulfonyl)imide and 1-butyl-1-methylpiperidinium trifluoromethylsulfonate (PPCFSO) in diglyme and 2-methoxyethylamine (MOEA) solvent, achieving efficient Mg plating/stripping, cathode compatibility, and high anodic stability.

Complementary classification of hypertrophic cardiomyopathy using unsupervised cluster analysis on left ventricular function.

Contemporary classification of hypertrophic cardiomyopathy (HCM) was mainly based on the site of myocardial hypertrophy and left ventricular outflow tract obstruction. A complementary classification based on left ventricular function could provide a powerful tool to identify individuals with high risk of adverse cardiovascular outcomes and guide individualized managements. Multi-dimensional echocardiographic parameters of left ventricular function derived from conventional echocardiography, tissue Doppler imaging, and speckle tracking echocardiography were obtained in 266 HCM patients and 169 healthy controls (HCs).

Gamma-glutamyl transferase-to-lymphocyte ratio as a prognostic marker in patients with hepatocellular carcinoma undergoing hepatectomy.

Background: We investigated the utility of gamma-glutamyl transferase-to-lymphocyte ratio (GLR) as a predictive indicator for postoperative survival in patients with hepatocellular carcinoma (HCC) across different time periods and developed a predictive model based on this.

Aim: To evaluate the prognostic accuracy of GLR for overall survival (OS) in patients with HCC and its impact over time.

Methods: This study enrolled 301 patients with HCC treated with curative hepatectomy.

Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia.

Hair follicle neural crest stem cells reside in the bulge region of the outer root sheath of hair follicles, originate from the ectoderm, and have multidirectional differentiation potential, making them ideal candidates for tissue engineering applications. These cells mainly reside in a hypoxic microenvironment that favors the maintenance of stemness. Recently, many studies have elucidated the involvement of the Hippo pathway in the regulation of stem cell fate.

The impact of lymph node dissection on stage I ovarian endometrioid carcinoma: A US-China Comparative Analysis.

This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify the optimal LND range for improved survival. By analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database conducted in USA and NUWA database in China, we found that patients who underwent LND in the SEER cohort exhibited significantly improved long-term survival rates compared to those who did not undergo LND, while the difference was not statistically significant in the NUWA cohort. Cox regression and restricted cubic spline analyses indicated an inverted U-shaped association between the number of LNDs and hazard ratios, identifying 29-34 lymph nodes as the optimal range.

Plant metabolomics: applications and challenges in the era of multi-omics big data.

Plant metabolites are crucial for the growth, development, environmental adaptation, and nutritional quality of plants. Plant metabolomics, a key branch of systems biology, involves the comprehensive analysis and interpretation of the composition, variation, and functions of these metabolites. Advances in technology have transformed plant metabolomics into a sophisticated process involving sample collection, metabolite extraction, high-throughput analysis, data processing, and multidimensional statistical analysis.

Magnetar emergence in a peculiar gamma-ray burst from a compact star merger.

The central engine that powers gamma-ray bursts (GRBs), the most powerful explosions in the universe, is still not identified. Besides hyper-accreting black holes, rapidly spinning and highly magnetized neutron stars, known as millisecond magnetars, have been suggested to power both long and short GRBs. The presence of a magnetar engine following compact star mergers is of particular interest as it would provide essential constraints on the poorly understood equation of state for neutron stars.

A Key Fragment in Carbon Schwarzite Unit Cells and Its Triple [6]Helicene Precursor.

This study explores two structurally related π-skeletons. The π-skeleton of compounds 1a-e containing three heptagons represents a key fragment in theoretical carbon schwarzites, while that of 2a-b is a triple [6]helicene. Compounds 1a-e were synthesized via Scholl reactions, and using a weaker acid allowed the reaction to stop at an intermediate stage, yielding 2a-b.

Daily Treatment Monitoring for Patients Receiving Home-Based Peritoneal Dialysis and Prediction of Heart Failure Risk: mHealth Tool Development and Modeling Study.

Background: Peritoneal dialysis is one of the major renal replacement modalities for patients with end-stage renal disease. Heart failure is a common adverse event among patients who undergo peritoneal dialysis treatment, especially for those who undergo continuous ambulatory peritoneal dialysis at home, because of the lack of professional input-output volume monitoring and management during treatment.

Objective: This study aims to develop novel mobile health (mHealth) tools to improve the quality of home-based continuous ambulatory peritoneal dialysis treatment and to build a prediction model of heart failure based on the system's daily treatment monitoring data.

A preliminary follow-up study on irreversible electroporation therapy in older patients with prostate cancer.

Background: Prostate cancer is a prevalent condition among older males, with radical prostatectomy being the standard treatment. However, this procedure can inevitably impact urinary and sexual functions. Irreversible electroporation represents an innovative therapeutic approach that employs high-voltage electrical pulses to selectively eradicate tumor cells, potentially preserving vital normal tissue.

Changes in Parathyroid Hormone Across the Spectrum of Renin-Independent Aldosteronism.

Context: Primary aldosteronism (PA) is the most common cause of endocrine hypertension. While elevated serum parathyroid hormone (PTH) levels have been associated with PA, the extent and nature of this relationship across the broader spectrum of renin-independent aldosteronism remain unclear.

Objective: This study aims to elucidate the relationship between PTH and aldosterone excess across the spectrum of renin-independent aldosteronism.

Hydrodynamic efficient cell capture and pairing method on microfluidic cell electrofusion chip.

Cell fusion is a widely employed process in various biological procedures, demonstrating significant application value in biotechnology. Cell pairing is a crucial manipulation for cell fusion. Standard fusion techniques, however, often provide poor and random cell contact, leading to low yields.

Protocadherin 17 weakens the lenvatinib resistance of liver cancer through inducing ferroptosis.

Lenvatinib has been employed in the treatment of advanced liver cancer; however, its clinical application is significantly impeded by frequent drug resistance. Recent studies have revealed that lenvatinib treatment triggers ferroptosis in liver cancer cells, providing a novel approach to addressing lenvatinib resistance. In this study, we initially validated the induction of ferroptosis by lenvatinib in liver cancer cells.

Comprehensive review of chickpea (Cicer arietinum): Nutritional significance, health benefits, techno-functionalities, and food applications.

Chickpeas (Cicer arietinum L.) are globally valued legume known for their affordability, nutritional significance, and health benefits. They are rich in protein, fiber, vitamins, and minerals such as iron, zinc, folate, and magnesium.

lncRNA ACVR2B-AS1 modulates thyroid cancer progression by regulating miR-195-5p.

Background: lncRNAs are key regulators in thyroid cancer (TC). While lncRNA ACVR2B-AS1 has been proposed as a potential TC biomarker, its role remains underexplored. This study aims to clarify its clinical significance in TC and investigate its molecular mechanism.

Comprehensive analysis of Enterobacteriaceae IncX plasmids reveals robust conjugation regulators PrfaH, H-NS, and conjugation-fitness tradeoff.

Conjugative IncX plasmids are vital for spreading clinically significant antibiotic resistance genes. We identified key factors governing the conjugative process of IncX plasmids, the plasmid encoded activator PrfaH and inhibitor H-NS. Deletion of prfaH completely abolishes conjugative transfer, and the PrfaH binding site is an ops-like sequence located downstream of the prfaH promoter.

[Research progress on polymorphism of vitamin D and its receptor gene and susceptibility to bone tuberculosis].

Bone tuberculosis is one of the main lesions of extrapulmonary tuberculosis, and the affected site shows local pain and limited movement, and the severe patients face a higher risk of teratogenicity and disability. Especially in the context of the increasing spread of multidrug-resistant tuberculosis, it is particularly urgent to seek innovative treatment options. In recent years, vitamin D plays an important role in the prevention and treatment of bone tuberculosis, and the mechanism of action has been continuously explored.

Origin and evolution of the North Atlantic Oscillation.

The North Atlantic Oscillation (NAO), the dominant mode of atmospheric variability in the North Atlantic region, plays a crucial role in weather and climate. Here, to investigate when the NAO emerged and how it evolved over geological timescales, we analyzed time-slice paleoclimate simulations during the breakup of the supercontinent Pangea, starting 160 million years ago (Ma). Our findings indicate that a present-day-like NAO mode gradually formed between 80 Ma and 60 Ma, driven by the expansion of the North Atlantic Ocean and the enhanced land-ocean contrast.

Temporal Logic Disturbance Rejection Control of Nonlinear Systems Using Control Barrier Functions.

The high level of autonomy within autonomous systems demands new control strategies to achieve more complex objectives while ensuring both safety and robustness, rather than relying solely on a given reference. To this end, this article addresses the problem of temporal logic disturbance rejection control (TLDRC) for a class of nonlinear systems subject to disturbances. Signal temporal logic (STL) specifications are introduced for the representation of complex tasks.

Multimodal trajectory prediction for intelligent connected vehicles in complex road scenarios based on causal reasoning and driving cognition characteristics.

The safe and efficient operation of smart Intelligent vehicles relies heavily on accurate trajectory prediction techniques. Existing methods improve prediction accuracy by introducing scene context information, but lack the causal perspective to explain why scene context improves prediction performance. In addition, current multimodal trajectory prediction methods are mostly target-driven and implicitly fused, relying too much on the density of candidate targets, as well as ignoring the road rule constraints, which leads to a lack of anthropomorphic properties in the model's prediction results.