Publications by authors named "Jun Y Tay"
Objectives: Subclinical tuberculosis (TB) is challenging to diagnose due to the lack of a clear definition and symptoms. This study aimed to describe the subclinical disease spectrum among people with culture-confirmed pulmonary TB routinely diagnosed in Singapore, a country with moderate incidence, using different definitions. It also aimed to identify risk factors for subclinical TB and the current diagnostic approaches in detecting subclinical TB.
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- Pathogenic variant (PV)-associated breast cancers are often linked to hereditary conditions like Hereditary Breast and Ovarian Cancer (HBOC) syndrome, showing more aggressive behavior and worse outcomes than sporadic cases.
- PVs affect the tumor microenvironment by interacting with immune and stromal cells, promoting processes like angiogenesis and epithelial-mesenchymal transition, as well as influencing epigenetic factors such as DNA methylation.
- Lysine-specific demethylase 1 (LSD-1) is a key epigenetic regulator linked to poor cancer prognosis, and inhibiting LSD-1 could offer a novel therapeutic strategy for managing breast cancer in patients with pathogenic variants.
Introduction: Tuberculosis (TB) remains endemic in Singapore. Singapore's clinical practice guidelines for the management of tuberculosis were first published in 2016. Since then, there have been major new advances in the clinical management of TB, ranging from diagnostics to new drugs and treatment regimens.
View Article and Find Full Text PDFThe yield of contact investigation on relapsed tuberculosis (TB) cases can guide strategies and resource allocation in the TB control programme. We conducted a retrospective cohort study to review the yield of contact investigation in relapsed TB cases and identify factors associated with TB infection (TBI) among close contacts of relapsed TB cases notified between 2018 and 2022 in Singapore. TB infection positivity was higher among contacts of relapsed cases which were culture-positive complex compared to those who were only polymerase chain reaction (PCR)-positive (14.
View Article and Find Full Text PDFBackground: The performance of real-time reverse transcription polymerase chain reaction (rRT-PCR) for SARS-CoV-2 varies with sampling site(s), illness stage, and infection site.
Methods: Unilateral nasopharyngeal, nasal midturbinate, throat swabs, and saliva were simultaneously sampled for SARS-CoV-2 rRT-PCR from suspected or confirmed cases of COVID-19. True positives were defined as patients with at least 1 SARS-CoV-2 detected by rRT-PCR from any site on the evaluation day or at any time point thereafter, until discharge.