Publications by authors named "Jun Xiang"

Fuchs endothelial corneal dystrophy (FECD) is the leading cause of vision-threatening corneal endothelial dystrophy without pharmacologic treatments. Corneal endothelial-mesenchymal transition (cEndMT), a specific cellular phenotypic transition, is implicated in the vicious cycle in FECD pathogenesis. Here, we investigated the reversible epigenetic regulation of N-methyladenosine (mA) during cEndMT process and FECD progression.

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Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME). Here we reveal that hypoxia inducible factor-1α (HIF-1α) is a driver of cuproptosis resistance in solid tumor.

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Despite significant progress in diagnostic and therapeutic modalities, lung adenocarcinoma (LUAD) still exhibits a high recurrence risk and a low 5-year survival rate. Reliable prognostic signatures are imperative for risk stratification in LUAD patients. This study encompassed 2740 patients from 23 LUAD cohorts, including one single-cell RNA sequencing (scRNA-seq) dataset, five bulk RNA-seq datasets, and 17 microarray datasets.

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This study aimed to evaluate corneal stromal and endothelial alterations after vitrectomy using in vivo confocal microscopy (IVCM), focusing on the implications of different surgical techniques and tamponades. In this prospective cohort study, a total of 99 eyes from 98 consecutive patients scheduled for vitrectomy were initially enrolled. Each subject underwent a comprehensive ophthalmic evaluation, including fundus examination, intraocular pressure assessment, and IVCM imaging.

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Genome-wide association studies have identified thousands of genetic variants associated with non-small cell lung cancer (NSCLC), however, it is still challenging to determine the causal variants and to improve disease risk prediction. Here, we applied massively parallel reporter assays to perform NSCLC variant-to-function mapping at scale. A total of 1249 candidate variants were evaluated, and 30 potential causal variants within 12 loci were identified.

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Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti-ferroptosis therapy. Through drug screening, it is found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC to ferroptosis. The combination of HDACi and ferroptosis inducers synergically suppresses CRC growth both in vivo and in vitro.

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Nanosecond pulsed electric fields (nsPEFs) can induce protein-mediated electroporation (PMEP) in voltage-gated ion channels. However, their effects on the tetrameric structure of voltage-gated potassium (Kv) channels remain unexplored. Our study pioneered the molecular dynamics (MD) investigation of the open-state (O) Kv channel to understand the effects of PMEP under unipolar and bipolar pulses (UP and BP).

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Background: This study aims to explore the diagnostic significance of basal sex hormone levels and pelvic B-mode ultrasound in the context of central precocious puberty (CPP) in female children.

Methods: A cohort study was conducted at the Third Affiliated Hospital of Wenzhou Medical University from January 2014 to January 2024. The study enrolled female children exhibiting early breast development before the age of 8 and subjected them to gonadotropin-releasing hormone (GnRH) stimulation tests.

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Article Synopsis
  • Heparin is a complex polysaccharide used in medicine, and isolating it from biological mixtures like proteins is challenging, but this study introduces an eco-friendly method to create quaternized FeO@chitosan nanoparticles (QFCNs) for effective heparin adsorption.
  • The QFCNs achieved a high adsorption efficiency of 90.02% and showed better performance than existing adsorbents, indicating their potential for selective capture of heparin, especially in a mixture with BSA at neutral pH.
  • X-ray photoelectron spectroscopy suggested that the mechanism of adsorption involves electrostatic attraction between heparin and the quaternary ammonium groups on the QFCNs, making them a promising option for efficient and recyclable
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Ethnopharmacological Relevance: Xiao-xu-ming decoction (XXMD), a prominent traditional Chinese medicinal formula historically revered for stroke treatment, demonstrates pronounced efficacy in ameliorating ischemic stroke injury.

Aim Of The Study: This study aims to investigate the effects and mechanisms of XXMD on neuroprotection subsequent to cerebral ischemia/reperfusion in vivo and in vitro.

Materials And Methods: Neurobehavioral test, TTC staining, HE staining and nissl staining were used to examine the neuroprotective effect of XXMD on cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats.

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Introduction: Sports gains reflect the sports development of college students, which is a direct reflection of the quality of school sports work, while the perception of sports environment, physical activity behavior, and self-efficacy in sports learning are closely related to their sports gains, which directly affects their effectiveness and interest in sports learning.

Objective: To investigate the effects of perceived sports environment on Chinese college students' sport gains, and to verify the mediating roles of physical activity behavior and self-efficacy in sport learning.

Methods: A survey of 2,207 Chinese university students was conducted using the sport environment perception scale, sport gain scale, physical activity behavior scale, and sport learning self-efficacy scale.

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Anaplastic thyroid cancer (ATC) is the most lethal tumor arising from thyroid follicular epithelium. Lenvatinib is an off-label use option for ATC patients in many countries but an approved prescription in Japan. However, lenvatinib resistance is a substantial clinical challenge.

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Volatile constituents are critical to the flavor of tea, but the changes in Enshi Yulu tea during the processing have not been clearly understood. Using headspace solid phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME/GC-MS) techniques, we analyze the aroma components of Enshi Yulu tea and changes in them during the processing stages. In total, 242 volatile compounds were identified.

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Fidelity estimation is a necessary tool for evaluating noise in quantum measurement and quantum computation. The traditional fidelity estimation is to calculate the distance between two density matrices by employing direct fidelity estimation, which consumes too much copies of state. To reduce the number of copies of the state, we develop optimal fidelity estimation by proposing an optimal model.

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Article Synopsis
  • Deficiency in DNA-damage repair (DDR) genes is linked to a higher risk of lung cancer, especially due to rare loss-of-function variants, prompting research into the role of rare regulatory variants.* -
  • By analyzing whole-genome sequencing data from nearly 3,000 lung cancer patients and 3,000 controls, researchers identified 750 rare functional regulatory variants (frVars) that affect the transcriptional activity of DDR gene promoters, with a notable increase in these variants among lung cancer cases.* -
  • Specifically, down-regulated transcriptional variants (dr-frVars) were significantly associated with lung cancer risk, highlighting the importance of functional regulatory variants in DDR genes, alongside more commonly studied variants, in contributing to
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Background: Exertional heat stroke (EHS) is a critical condition arising from prolonged physical exertion in high temperatures that typically presents with normal hemoglobin levels. However, atypical presentations can also occur, leading to significant complications such as hemolytic anemia and organ dysfunction.

Case Summary: This case report describes a male patient who experienced moderate-to-severe anemia that was difficult to correct, with a confirmed diagnosis of microangiopathic hemolytic anemia accompanying multiple organ dysfunction syndrome, indicative of critical EHS.

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Recent empirical research posits a link between lymphocyte subgroups and both the incidence and prognosis of sepsis. Nevertheless, the potential influence of multiple confounding variables obscures any clear causative correlation. Utilizing a 2-sample Mendelian randomization approach, we conducted a meta-analysis of lymphocyte subgroups.

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Herein, a BiFeO@BiFeO heterostructure with a high specific surface area of 30.07 m g and abundant heterogeneous interfaces was successfully fabricated and applied to supercapacitors for the first time. The BiFeO@BiFeO electrode exhibits a high specific capacity (550.

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Colorectal cancer (CRC) is a prevalent malignancy with a high mortality rate, primarily due to liver metastasis. This study explores the role of centromere protein N (CENP-N) in mediating the methylation of septin 9 (SEPT9) and its subsequent effects on aerobic glycolysis and liver metastasis in CRC. We employed in vitro and in vivo experiments, including single-cell RNA sequencing, methylation-specific PCR (MSP), ChIP assays, and various functional assays to assess the impact of CENP-N and SEPT9 on CRC cell proliferation, migration, invasion, and metabolic reprogramming.

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This study examines intergenerational support (IGS) and its impact on the subjective well-being of older adults in Chinese families, focusing on both upward and downward support. Data from the 2018 China Family Panel Studies show considerable mutual support between parents and children. Support from children to parents significantly improves the well-being of older adults, while support from parents to children has less impact.

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Dwarf bamboo () is a crucial food source for the giant pandas. With its shallow root system and rapid growth, dwarf bamboo is highly sensitive to drought stress and nitrogen deposition, both major concerns of global climate change affecting plant growth and rhizosphere environments. However, few reports address the response mechanisms of the dwarf bamboo rhizosphere environment to these two factors.

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Basic helix-loop-helix (bHLH) proteins comprise one of the largest families of transcription factors in plants, which play roles in plant development, secondary metabolism, and the response to biotic/abiotic stresses. However, the roles of bHLH proteins in thermotolerance are largely unknown. Herein, we identified a heat-inducible member of the bHLH family in lily (Lilium longiflorum), named LlbHLH87, which plays a role in thermotolerance.

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Article Synopsis
  • Donor-acceptor Stenhouse adducts (DASAs) are eco-friendly compounds that can change form when exposed to light and heat, making them ideal for smart materials, but achieving quick transitions in solid forms with high bio-content is challenging.
  • Researchers created a new kind of sustainable nano/micro capsule with 57% bio-content, combining PMMA and a special acid mixture, which allows for fast and effective isomerization of a specific DASA, achieving up to 90% efficiency under mild conditions.
  • This breakthrough not only overcomes previous challenges in utilizing high bio-content materials but also opens up new applications for DASAs, such as in rewritable papers
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Background: Abnormal arachidonic acid metabolism in the tumor microenvironment is closely related to cancer progression; however, thyroid cancer was rarely researched.

Methods: Through lipidomic analysis, we disclosed that dysregulated arachidonic acid metabolism plays dual effects on thyroid cancer. The promoting role of arachidonic acid in the progression of thyroid cancer cells was evaluated utilizing cell viability (CCK-8 assay) and transwell invasion assays, confirmed by corresponding inhibitors.

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