Development and validation of the head and neck cancer psychosocial distress scale (HNCPDS) to identify patients at high risk for psychological problems : a multicenter study.

To develop the Head and Neck Cancer Psychosocial Distress Scale (HNCPDS) with the aim of identifying high-risk individuals for psychosocial distress among patients, and to assess its reliability, validity and applicability. Using the classical test theory, a total of 435 head and neck cancer patients from six tertiary hospitals in China were recruited for developing the HNCPDS. Delphi expert consultation and item analysis were used to improve the content validity of the preliminary HNCPDS.

Statistical and network analyses reveal mechanisms for the enhancement of macrophage immunity by manganese in infection.

Tuberculosis is a significant infectious disease that poses a serious risk to human health. Our previous research has indicated that manganese ions reduce the bacterial load of in macrophages, but the exact immune defense mechanism remains unknown. Several critical proteins and pathways involved in the host's immune response during this process are still unidentified.

Elucidating the molecular mechanisms underlying anti-inflammatory effects of Morchella esculenta in the arachidonic acid metabolic pathway by network pharmacology and molecular docking.

Morchella esculenta is an edible fungus with a uniquely delicious flavor and remarkable benefits for health. Herein, the molecular mechanism underlying the anti-inflammatory effects of Morchella esculenta was elucidated using molecular docking and network pharmacology. NPASS, Super-pred, SEA, Swiss Target Prediction, GeneCards, DisGeNET, Omim database, and STRING platform were used to select anti-inflammatory targets and construct target protein interaction networks using the active ingredients of Morchella esculenta.

A novel HBI-based ratiometric fluorescent probe for rapid detection of trifluoroborate.

A 2-(2'-hydroxyphenyl)benzimidazole (HBI)-based ratiometric fluorescent probe, known as BTEP, was synthesized using 5-bromosalicylaldehyde as the raw material Sonogashira coupling and condensation reaction. This probe was designed for rapid detection of boron trifluoride solutions and gases. The N and O coordination atoms in the probe undergo a boron difluoride addition with BF, which affects the process of excited state intramolecular proton transfer (ESIPT) leading to a blue shift of fluorescence emission.

DynamicSleepNet: a multi-exit neural network with adaptive inference time for sleep stage classification.

Sleep is an essential human physiological behavior, and the quality of sleep directly affects a person's physical and mental state. In clinical medicine, sleep stage is an important basis for doctors to diagnose and treat sleep disorders. The traditional method of classifying sleep stages requires sleep experts to classify them manually, and the whole process is time-consuming and laborious.

The clinical relevance and prediction efficacy from therapy of tumor microenvironment related signature score in colorectal cancer.

Introduction: As the top 3 cancer in terms of incidence and mortality, the first-line treatment for CRC includes FOLFOX, FOLFIRI, Cetuximab or immunotherapy. However, the drug sensitivity of patients to regimens is different. There has been increasing evidence that immune components of TME can affect the sensitivity of patients to drugs.

Effect and cerebral mechanism of moxibustion at heat-sensitized Yaoyangguan (GV3) in patients with lumbar disc herniation and myofascial pain syndrome by resting-state functionality magnetic resonance imaging: protocol for an observational study.

We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan (GV3) in patients with lumbar disc herniation (LDH) and myofascial pain syndrome (MPS). In an assessor-blinded observational study, we will include 15 LDH and 15 MPS. They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan (GV3).

Percutaneous Fixation of Levine-Edwards Type II Hangman's Fractures Under the Guidance of an Orthopedic Robot.

There is no consensus regarding the optimal treatment for unstable hangman's fractures. Conservative treatment, although time-consuming and associated with complications such as nonunion, neck stiffness, and pseudarthrosis formation, is still preferred by many surgeons. With the development of minimally invasive techniques, surgical treatment is trending in recent years.

A network pharmacology-based approach to explore the therapeutic potential of Sceletium tortuosum in the treatment of neurodegenerative disorders.

Sceletium tortuosum (SCT) has been utilized medicinally by indigenous Koi-San people purportedly for mood elevation. SCT extracts are reported to be neuroprotective and have efficacy in improving cognition. However, it is still unclear which of the pharmacological mechanisms of SCT contribute to the therapeutic potential for neurodegenerative disorders.

The comparison between the effect of Glycyrrhizae uralensis (Gan-Cao) and Montelukast on the expression of T-bet and GATA-3 genes in children with allergic asthma.

Pediatric allergic asthma is a chronic disease that affects the lungs and airways. If a child is exposed to certain stimulants such as pollen inhalation, colds, or respiratory infections, the lungs become inflamed and if left untreated can lead to dangerous asthma attacks. One of the most important treatments for this disease is the use of leukotriene modulators, such as montelukast.

Construction and Verification of a Radiation Pneumonia Prediction Model Based on Multiple Parameters.

Objective: Patients with lung cancer are at risk of radiation pneumonia (RP) after receiving radiotherapy. We established a prediction model according to the critical indicators extracted from radiation pneumonia patients.

Materials And Methods: 74 radiation pneumonia patients were involved in the training set.

The complete chloroplast genome of Maxim.

The complete chloroplast genome of Maxim. was sequenced and assembled. It is a circular form of 155949 bp in length, which was separated into four distinct regions, a large single copy (LSC) of 84375 bp, a small single copy region (SSC) of 18894 bp, two inverted repeats (IR) of 26340 bp.

Sub-five-optical-cycle pulse generation from a Kerr-lens mode-locked Yb:CaYAlO laser.

Direct generation of ultrashort few-optical-cycle pulses in various wavelength regions has attracted great attention in recent decades. In this paper, generation of less than five-optical-cycle pulses from a Kerr-lens mode-locked ${\rm Yb}{:}{\rm CaYAlO}_4$ laser is demonstrated. Pumped by a 976 nm fiber laser, stable near-Fourier-transform-limited ultrashort soliton pulses centered around 1080 nm with a repetition rate of ${\sim}{113.

The effectiveness of Du moxibustion for chronic obstructive pulmonary disease: A protocol for systematic review and meta-analysis of randomized clinical trials.

Background: As a common respiratory disease, Chronic Obstructive Pulmonary Disease (COPD) develops progressively. Du moxibustion can effectively treat COPD, and no adverse reactions have been reported. This research mainly evaluated the efficacy and safety of Du moxibustion in the treatment of COPD.

HS-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice.

Purpose: This thesis was to investigate the protective effect and mechanism of HS-mediated aerobic exercise on the antagonism of the hippocampus inflammatory response in CUMS-depressed mice.

Method: Seventy C57BL/6 mice were randomly divided into control group (CG), model control group (MG), model exercise group (ME), HS enhanced group (HG) and HS enhanced and exercise group (HE). All mice except CG underwent a 28-day CUMS depression model.

The influence of tolfenpyrad on fitness, development, and reproduction in parents and offspring of Coccinella septempunctata.

Coccinella septempunctata (ladybird) is one of the foremost natural predators that feed on aphids. Thus, C. septempunctata serves as an effective biological control agent in integrated pest management (IPM) programs.

Identification of Key Genes in Lung Adenocarcinoma and Establishment of Prognostic Mode.

Background: The development of human tumors is associated with the abnormal expression of various functional genes, and a massive tumor-based database needs to be deeply mined. Based on a multigene prediction model, access to urgent prognosis of patients has become possible.

Materials And Methods: We selected three RNA expression profiles (GSE32863, GSE10072, and GSE43458) from the lung adenocarcinoma (LUAD) database of the Gene Expression Omnibus (GEO) and analyzed the differentially expressed genes (DEGs) between tumor and normal tissue using GEO2R program.

Anti-cancer properties of specific Chinese herbal medicines for hepatocellular carcinoma treatment.

Aims: This essay explores the anti-cancer activity of specific Chinese herbal medicines to clarify how effective Chinese herbal medicine is used for handling hepatocellular carcinoma.

Methods: Literature form publica domain were studied and an analysis of anti-cancer activity of specific Chinese herbal medicines is presented in this review.

Results: Hepatocellular carcinoma is one of the most dangerous malignant tumors in the world.

Altered Mitochondrial Functions and Morphologies in Epithelial Cells Are Associated With Pathogenesis of Chronic Rhinosinusitis With Nasal Polyps.

Purpose: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory disease of the nasal and paranasal sinus mucosa. The disease is associated with mitochondrial dysfunction, structural changes in the mitochondria, and reactive oxygen species (ROS) generation. This study investigated whether there are functional and morphological changes in the mitochondria in the epithelial cells of nasal polyps (NPs) and enterotoxin B (SEB)-stimulated nasal epithelial cells.

Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation.

Circular RNAs (circRNAs) play an important role in bladder cancer (BC). Though circRNA involvement in BC has been reported, the underlying regulatory mechanisms are unknown. In this study, we performed EdU, CCK8, colony formation and Transwell assays to establish the role of circRGNEF in BC cell migration, proliferation, and invasion.

Alteration of Fungal Microbiota After 5-ASA Treatment in UC Patients.

The effect of treatment regimens on fungal microbiota is unclear in ulcerative colitis (UC) patients. Here, we aimed to clarify the effect of 5-aminosalicylic acid (5-ASA) treatment on gut fungal microbiota in UC patients. Fifty-seven UC patients, including 20 treatment-naïve and 37 5-ASA-treated, were recruited into an exploration study.

Artesunate promotes sensitivity to sorafenib in hepatocellular carcinoma.

Enhancing sensitivity of carcinoma to sorafenib (Sor) is critical to overcome the limits of high frequency resistance and moderate efficiency during chemotherapy for advanced hepatocellular carcinoma (HCC). Here, we promote sensitivity of HCC to Sor by combination with Artesunate (Art), a derivative of artemisinin extracted from Chinese medical herb. The positive synergy of Art on inhibiting HCC growth contributes 48% dosage of Sor to reduce tumor cell viability in vitro and tumor size in vivo.

Pharmacological effects of medicinal components of (Thunb.) DC.

Thunb. DC. (AL) has a long history as one of the important herbs used in East Asia.