Summary of emergency treatment experience of acute severe urethral trauma in pre-pubertal girls.

Purpose: To summarize our treatment experience of acute urethral trauma in pre-pubertal girls.

Methods: We retrospectively analyzed six pre-pubertal girls with acute severe urethral trauma who were admitted to our hospital from April 2003 to April 2023 and followed up.

Results: All six patients had pelvic fractures and vaginal injuries, and one had a rectal injury.

Heat exposure and respiratory diseases health outcomes: An umbrella review.

Introduction: Heat exposure and heatwaves are becoming more frequent and prolonged due to global warming. Heat exposure poses a significant potential risk for respiratory diseases. However, a comprehensive synthesis of existing evidence on the health impacts of heat exposure on respiratory diseases is lacking.

Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson's disease treatment through network pharmacology and transcriptomics.

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, poses significant challenges to single-target therapeutic strategies due to its complex etiology. This has driven interest in multi-target approaches, particularly those leveraging natural compounds. Pingchan granules (PCG), a traditional Chinese medicine composed of plant- and animal-derived compounds, have shown efficacy in alleviating PD symptoms.

Hyperthermic intraperitoneal chemotherapy after upfront cytoreductive surgery for stage III epithelial ovarian cancer: Follow-up of long-term survival.

Introduction: The survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) has been well defined at the time of interval cytoreductive surgery, but the role of HIPEC remains uncertain for patients with newly diagnosed advanced ovarian cancer in the upfront setting. The present study aimed to report the updated long-term survival outcomes after 5 years of follow-up from our previous multicenter retrospective cohort study to compare primary cytoreductive surgery (PCS) plus HIPEC with PCS alone among women with stage III epithelial ovarian cancer.

Material And Methods: This study was conducted at five high-volume gynecological medical centers in China from January 2010 to May 2017.

Effect of Electropulsing Current Density on the Strength-Ductility Synergy of Extruded Mg-6Al-1Zn Alloy.

The difficulty in enhancing both tensile strength and ductility is limiting the development of high-performance Mg alloys. The "plastic deformation + electropulsing (EP) treatment" is an effective process for modifying the microstructure and enhancing the mechanical properties of metals. In this work, the influence of the current density of EP treatment on the microstructure and tensile property evolution of the as-extruded Mg-6Al-1Zn alloy was systematically investigated.

Bioinformatics analysis of genes associated with disulfidptosis in spinal cord injury.

Research findings indicate that programmed cell death (PCD) plays a pivotal role in the pathophysiology of spinal cord injury (SCI), and a recently discovered form of cell death, disulfidptosis, has emerged as a novel phenomenon. However, the characterization of disulfidptosis-related genes in SCI remains insufficiently explored. We retrieved SCI-related data from the Gene Expression Omnibus (GEO) database and identified three key genes associated with disulfidptosis in human SCI (CAPZB, SLC3A2, and TLN1), whose mediated signaling pathways are closely intertwined with SCI.

Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor.

The objective of this study is to explore the association of common genetic variation of anxiety disorders and essential tremor (ET). We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 504 age and gender-matched healthy controls from eastern China using a MassARRAY system. The association between candidate variants and ET patients was evaluated using gene-based analysis.

Clinical characteristics, complications and satisfaction of megameatus intact prepuce (MIP) hypospadias variant: a 15 year retrospective study.

Background: To analyze the clinical characteristics, complications and patients satisfaction of MIP hypospadias variant.

Methods: A retrospective analysis was performed for 31 patients with MIP admitted to our hospital from January 2008 to February 2023. All enrolled patients underwent telephone follow-up and a survey was conducted on the satisfaction of patients and their families.

The role of mitophagy-related genes in prognosis and immunotherapy of cutaneous melanoma: a comprehensive analysis based on single-cell RNA sequencing and machine learning.

Mitophagy, the selective degradation of mitochondria by autophagy, plays a crucial role in cancer progression and therapy response. This study aims to elucidate the role of mitophagy-related genes (MRGs) in cutaneous melanoma (CM) through single-cell RNA sequencing (scRNA-seq) and machine learning approaches, ultimately developing a predictive model for patient prognosis. The scRNA-seq data, bulk transcriptomic data, and clinical data of CM were obtained from publicly available databases.

Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin MRI Study.

Objective: Our aim was to research the neuromelanin-sensitive magnetic resonance imaging (NM-MRI) features of the locus coeruleus (LC) in essential tremor (ET) patients of various cognitive states and to explore the relationships between these features and cognition.

Methods: We recruited three groups of participants, including 30 ET patients with mild cognitive impairment (ET-MCI), 57 ET patients with normal cognition (ET-NC), and 105 healthy controls (HCs). All participants underwent MRI scanning and clinical evaluation.

Adipose Mesenchymal Stem Cell-Derived Exosomes as Nanocarriers for Treating Musculoskeletal Disorders.

Musculoskeletal disorders are a series of diseases involving bone, muscle, cartilage, and tendon, mainly caused by chronic strain, degenerative changes, and structural damage due to trauma. The disorders limit the function of patients due to pain and significantly reduce their quality of life. In recent years, adipose-derived mesenchymal stem cells have been extensively applied in regeneration medicine research due to their particular abilities of self-renewal, differentiation, and targeted homing and are more easily accessed compared with other sources.

Alkali-Cation-Selective Arylation Promoted by Ion Recognition of Foldamers.

To explore alkali-cation selectivity at the chemical reaction level, in this work, we for the first time focused on the different behaviors of potassium and sodium ions in intra- and intermolecular arylation. We prepared a series of aromatic foldamers based on pyridine/oxadiazole alternating sequences as the catalysts for the arylation. Our studies revealed that foldamers can selectively recognize K over Na and the interactions between foldamers and K drive the arylation with a significant yield.

Metabolomic profiling identifies metabolites in the pheromone glands of associated with the synthesis and release of female pheromone signals.

The tea moth pest, is an economically important and highly damaging pest that drastically affects tea plant leaves. The chemical composition of its pheromone glands metabolites before and during calling period has not been reported yet. Therefore, the present study aimed at the metabolomic profiling of female moths' sex pheromones glands before and during calling period using gas chromatography time-of-flight mass spectrometry.

Heterogeneous Microstructure and Tensile Properties of FeMnCoCr Metastable High-Entropy Alloy.

Face-centered cubic (FCC)-structured high-entropy alloys (HEAs) are facing a major challenge due to a trade-off between strength and ductility. In this paper, we systematically investigated the microstructural evolution and tensile properties of metastable dual-phase (DP) FeMnCoCr HEAs via cold rolling and partial recrystallized annealing, which resulted in a heterogeneous microstructure, and by inducing strengthening and strain-hardening through heterogeneous deformation-induced (HDI) strategies. The results show that the alloy was annealed at 600 °C for 10 min, exhibiting a good combination of strength and ductility.

No causal relationship between ankylosing spondylitis and Parkinson's disease: Insights from Mendelian randomization studies.

Background: Retrospective cohort and cross-sectional studies have indicated an association between ankylosing spondylitis (AS) and Parkinson's disease (PD). However, owing the multitude of limitations, a consistent conclusion has not been determined. Furthermore, whether a causal relationship exists between these two diseases remains unclear.

Unsupervised definition of two clinical subtypes of Essential tremor and the underlying brain topology.

Background: Essential tremor (ET) is one of the most prevalent neurological diseases varying considerably in clinical manifestations and prognosis, which indicates the existence of subtypes. Identifying ET subtypes is crucial for explaining clinical heterogeneity. This study aimed to identify ET subtypes using unsupervised clustering analysis based on clinical manifestations and explore underlying brain topology within both functional and structural networks.

Effects of Perillaldehyde and Polyamines on Defense Mechanisms of Sweet Potatoes against .

Sweet potato () serves as a significant food and economic crop worldwide. However, its production and safety are jeopardized by black rot, a disease caused by . Although polyamines (PAs) are common biological growth factors, their function in the storage of fruits and vegetables remains poorly understood.

Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease.

Background And Purpose: Neurodegeneration is uneven in Parkinson's disease (PD). This study aimed to investigate spatiotemporal neurodegeneration in functional subregions of the substantia nigra (SN) and their connected cortex and subcortex in people with PD.

Methods: A total of 120 patients with early-stage PD, 45 patients with advanced PD, and 120 healthy controls (HCs) were enrolled.

Bladder cancer immune-related markers: diagnosis, surveillance, and prognosis.

As an immune-related tumor type, bladder cancer has been attracting much attention in the study of its markers. In recent years, researchers have made rapid progress in the study of immune-related markers for bladder cancer. Studies have shown that immune-related markers play an important role in the diagnosis, prognosis assessment and treatment of bladder cancer.

Prediction of Ki-67 expression and malignant potential in gastrointestinal stromal tumors: novel models based on CE-CT and serological indicators.

Purpose: To identify more reliable imaging and serological indicators for predicting Ki-67 expression and malignant potential in gastrointestinal stromal tumors, as well as to develop a preoperative prediction model with clinical utility.

Patients And Methods: This study retrospectively analyzed patients with gastrointestinal stromal tumors (GIST) diagnosed at the First Affiliated Hospital of Jinzhou Medical University between May 2018 and May 2024. Univariate logistic analyses, two-way stepwise regression, P-value stepwise regression, and LASSO regression were employed to screen for Ki-67 high expression and high malignant potential risk factors associated with GIST.

Structure-guided design and photochemical synthesis of new carbamo(dithioperoxo)thioates with improved potencies to SARS-CoV-2 3CL.

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has triggered a protracted global pandemic from 2019 to 2022, and posed a significant threat to human health. One of the non-structural proteins 3CL of SARS-CoV-2 is considered as a validated target for the development of inhibitors against the virus. Disulfiram has been reported as a covalent inhibitor of 3CL; however, its structure lacks bonding site with active pockets of 3CL and its highly symmetric structure doesn't match well with the irregular cavity of the active center, limiting its therapeutic applications.

Glycyrrhizic acid promote remyelination after peripheral nerve injury by reducing NF-κB activation.

Background: Peripheral nerve injury (PNI) causes motor and sensory defects, has strong impact on life quality and still has no effective therapy. Glycyrrhizic acid (GA) is one of the most widely used in traditional Chinese prescriptions and as a flavoring additive in the food industry; the aims of the study were to investigate the effects of GA during sciatic nerve regeneration in a mouse model of sciatic nerve crush injury.

Methods: We established peripheral nerve crush model and investigated the effects of GA.