Publications by authors named "Jun Sima"
Article Synopsis
- The study assessed the effectiveness of immune checkpoint inhibitors (ICIs) in 26 patients with advanced biliary tract cancers (BTCs) and identified potential biomarkers for predicting responses to treatment.
- Results indicated that a performance score (PS) of 0 was linked to better outcomes, while specific mutations (LRP1B, ERBB2, PKHD1) were associated with improved progression-free survival (PFS) in these patients.
- The research also found that patients with certain genetic alterations (19q amplification and 9p deletion) had poorer survival rates, highlighting the importance of genetic profiling in treatment decisions.
Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) can induce the apoptosis of many tumor cells and inhibit their growth. NS398 is an NSAID that inhibits COX-2 expression and induces tumor apoptosis via other pathways. The current study aims to observe the effects of NS398 on A549 cell apoptosis and investigate the apoptosis mechanism.
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