Publications by authors named "Jun Shigooka"
[Significance of the pharmacotherapy of schizophrenia in the emotional context processing of cognition].
Nihon Shinkei Seishin Yakurigaku Zasshi
June 2013
Article Synopsis
- Emotional disorders and cognitive dysfunctions are key focus areas in psychiatric treatment, with various biological mechanisms explored through methods like fear conditioning and rat models.
- Research showed that both fear-conditioned and methamphetamine-induced reverse tolerance rats exhibit increased dopamine release in the amygdala, which may relate to abnormal emotional processing in cognitive disorders like schizophrenia.
- Antipsychotic medications, such as haloperidol and clozapine, can help regulate this excessive dopamine release, suggesting their role in stabilizing emotional context processing and improving the connection between emotion and cognition.