Characteristics of ulnohumeral joint alignment in distal ulnar collateral ligament tears compared to proximal tears in baseball and softball players.

Background: Dysfunctional features of distal ulnar collateral ligament (UCL) tears remain unclear. We aimed to clarify the characteristics of valgus and rotational alignment of the ulnohumeral joint at rest in distal UCL tears compared with those in proximal tears.

Methods: The participants were baseball and softball players diagnosed with UCL tears, classified as proximal, middle, or distal.

[A Case of Salvage Lymphadenectomy with a Median Sternotomy after Definitive Chemoradiotherapy for Esophageal Cancer].

A 73-year-old man with middle thoracic esophageal squamous cell carcinoma(SCC)underwent definitive chemoradiotherapy( dCRT)with cisplatin and 5-fluorouracil(CF)concurrently administered with 60 Gy radiotherapy. Clinical complete response was achieved, but thoracic tracheal lymph node metastases(No. 106recL and No.

[A Case of Esophageal Squamous Cell Carcinoma with Gastric Intramural Metastasis Showing Pathological Complete Response after Neoadjuvant Chemotherapy with Docetaxel, Cisplatin, and 5-Fluorouracil].

A 75-year-old man presenting with dysphagia was referred to our hospital and diagnosed with advanced esophageal squamous cell carcinoma(ESCC)accompanied by an intramural metastasis in the gastric wall. Following completion of 3 courses of neoadjuvant chemotherapy(NAC)with docetaxel/cisplatin/5-fluorouracil(DCF), the patient underwent minimally invasive esophagectomy with 3-field lymph node dissection. Histopathological examination showed no viable cancer cells in the esophageal and gastric wall, confirming a complete response.

[Metastatic Carcinoma of Anal Fistula Caused by Implantation from Rectal Cancer-A Case Report].

A 73-year-old man with a history of perianal abscess and anal fistula for approximately 40 years visited our outpatient clinic because of anal pain. An anal tumor was found at the initial visit. Colonoscopy also revealed a circumferential rectosigmoid tumor located 15 cm from the anal verge.

[Thoracic Aortic Thrombosis during Preoperative 5-Fluorouracil plus Cisplatin Therapy for Esophageal Cancer].

We report a case of thoracic aortic thrombosis that developed during preoperative 5-fluorouracil plus cisplatin(FP)therap y for esophageal cancer. Esophagectomy was performed after continued FP therapy along with anticoagulant therapy. The patient was an 80-year-old man diagnosed with thoracic esophageal cancer(Mt, cT3rN1M1a, cStage ⅢA).

[Anaplastic Carcinoma with Osteoclast-Like Giant Cells of the Pancreas and Synchronous Liver Metastasis That Was Successfully Treated with Surgery and Chemotherapy-A Case Report].

A 76-year-old man presented with a pancreatic cystic lesion on magnetic resonance imaging before surgery for bladder cancer. Endoscopic ultrasound(EUS)suggested a malignant tumor such as a neuroendocrine neoplasm, but EUS-fine-needle aspiration was not performed. In addition, a single tumor 10 mm in size was found in the liver(S5), and liver metastasis was suspected.

Prognostic relevance of lymph node metastasis in pancreaticoduodenectomy for distal cholangiocarcinoma: Rational extent and number-based nodal classification for regional lymphadenectomy.

Background: We investigated the rational extent of regional lymphadenectomy and evaluated the prognostic impact of number-based regional nodal classification in patients with distal cholangiocarcinoma.

Methods: This study included 191 patients with distal cholangiocarcinoma who underwent pancreaticoduodenectomy. The nos.

Developmental patterns of athletic performance and physical fitness in youth baseball players: A longitudinal analysis.

This study aimed to evaluate developmental patterns in athletic performance during youth and determine their association with changes in physical fitness. The testing included three athletic performance (i.e.

Niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer: final results of a multicenter phase 2 study.

Objective: To evaluate the long-term efficacy and safety of niraparib in Japanese women with heavily pretreated ovarian cancer.

Methods: This was the follow-up analysis of a phase 2, multicenter, open-label, single-arm study in Japanese women with homologous recombination-deficient, platinum-sensitive, relapsed, high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who had completed 3-4 lines of chemotherapy and were poly(ADP-ribose) polymerase inhibitor naïve. Participants received niraparib (starting dose, 300 mg) once daily in continuous 28-day cycles until objective disease progression, unacceptable toxicity, or consent withdrawal.

Combined pancreaticoduodenectomy for advanced gallbladder cancer: Indications, surgical outcomes, and limitations.

Background: This study aimed to elucidate the clinical value of combined pancreaticoduodenectomy (PD) for advanced gallbladder cancer according to the mode of cancer spread in the pancreaticoduodenal region.

Methods: Patients who underwent combined PD for advanced gallbladder cancer were retrospectively reviewed. The mode of cancer spread in the pancreaticoduodenal region was defined as involvement of peripancreatic organs/structures alone, peripancreatic nodal metastasis alone, or both.

Landscape of homologous recombination deficiency in gastric cancer and clinical implications for first-line chemotherapy.

Background: Homologous recombination deficiency (HRD) is one of the crucial hallmarks of cancer. It is associated with a favorable response to platinum-based chemotherapy. We explored the distinctive clinicopathological features of gastric cancer (GC) with HRD and the clinical significance of HRD in platinum-based first-line chemotherapy for unresectable metastatic GC.

Clinical application of targeted tumour sequencing tests for detecting ERBB2 amplification and optimizing anti-HER2 therapy in gastric cancer.

Background: Evaluation of human epidermal growth factor receptor 2 (HER2) overexpression caused by erb-b2 receptor tyrosine kinase 2 (ERBB2) amplification (AMP) by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) is essential for treating unresectable metastatic gastric cancer (GC). A targeted tumour sequencing test enables comprehensive assessment of alterations in cancer-related genes, including ERBB2. This study aimed to evaluate the concordance between the targeted tumour sequencing test and IHC/FISH for detecting HER2-positive GC and to clarify the significance of ERBB2 AMP and concomitant genetic alterations in HER2 downstream pathways (DPs) in anti-HER2 therapy for unresectable metastatic GC patients.

Conversion surgery for initially unresectable locally advanced biliary tract cancer: A multicenter collaborative study conducted in Japan and Korea.

Background: Although surgical resection is the only curative treatment for biliary tract cancer, in some cases, the disease is diagnosed as unresectable at initial presentation. There are few reports of conversion surgery after the initial treatment for unresectable locally advanced biliary tract cancer. This study aimed to evaluate the efficacy and safety of conversion surgery in patients with initially unresectable locally advanced biliary tract cancer.

Prognostic Significance of NQO1 Expression in Non-neoplastic Esophageal Squamous Epithelium for Patients With Esophageal Cancer.

Background/aim: NAD(P)H dehydrogenase [quinone] 1 (NQO1), an antioxidant enzyme, confers resistance to anticancer agents. NQO1 C609T is a single-nucleotide polymorphism associated with reduced protein expression in the non-neoplastic esophageal squamous epithelium (ESE). This study aimed to investigate immunohistochemical NQO1 expression in non-neoplastic ESE and to elucidate its prognostic significance in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant therapy followed by esophagectomy.

Macroscopic type is implicated in the prognostic impact of initial chemotherapy on peritoneal lavage cytology-positive gastric cancer with no other noncurative factors.

Background: Initial chemotherapy (Initial-C) followed by surgery is a promising treatment strategy for peritoneal lavage cytology-positive gastric cancer (CY1 GC) with no other noncurative factors. The aim of this study was to investigate the survival advantage of Initial-C compared to initial surgery (Initial-S) for this disease according to the macroscopic type, which was associated with prognosis and the efficacy of chemotherapy in GC.

Methods: One hundred eighty-nine patients who were diagnosed with CY1 GC with no other noncurative factors at four institutions from January 2007 to December 2018 were enrolled.

[A Case of Appendiceal Carcinoma with BRAF V600E Mutation and Microsatellite Instability-High].

A 75-year-old woman presented to our hospital with abdominal pain and melena. Colonoscopy revealed an ulcer at the appendiceal orifice. Histopathological examination of biopsy specimens revealed adenocarcinoma.

[Resectable Pancreatic Cancer Successfully Treated with Neoadjuvant Chemotherapy Regimen Change to Modified FOLFIRINOX-A Case Report].

A 72-year-old woman presented with obstructive jaundice. Computed tomography revealed a 12-mm low-density mass in the head of the pancreas. She was diagnosed as having pancreatic cancer by endoscopic ultrasound-guided fine-needle aspiration.

[A Case of Intraductal Papillary Mucinous Adenocarcinoma with Hepatic Dysfunction Due to Tumor Perforation into the Bile Duct].

A 58-year-old woman presented with a complaint of weight loss. Abdominal computed tomography showed dilatation of the biliary and pancreatic ducts and a mural nodule in the pancreatic duct. The diagnosis was intraductal papillary mucinous neoplasm(IPMN).