Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate--4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial.

Polyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are synthesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate--4-hydroxybutyrate) [(P(3HB--4HB)] emerges as an attractive biomaterial to be applied in medical applications owing to its desirable mechanical and physical properties, non-genotoxicity and biocompatibility eliciting appropriate host tissue responses. The tailorable physical and chemical properties and easy surface functionalisation of P(3HB--4HB) increase its practicality to be developed as functional medical substitutes.

Elucidating the Surface Functionality of Biomimetic RGD Peptides Immobilized on Nano-P(3HB--4HB) for H9c2 Myoblast Cell Proliferation.

Biomaterial scaffolds play crucial role to promote cell proliferation and foster the regeneration of new tissues. The progress in material science has paved the way for the generation of ingenious biomaterials. However, these biomaterials require further optimization to be effectively used in existing clinical treatments.