Combination of PAMP-induced peptide signaling and its regulator SpWRKY65 boosts tomato resistance to Phytophthora infestans.

Late blight, caused by Phytophthora infestans (P. infestans), seriously compromises tomato growth and yield. PAMP-induced peptides (PIPs) are secreted peptides that act as endogenous elicitors, triggering plant immune responses.

Hot Electron Photoemission from Tunable Electron Affinity Semiconductor Cathodes.

A voltage-tunable negative electron affinity (NEA) semiconductor photocathode offers one key advantage over current materials such as cesiated NEA photocathodes: stability under ambient conditions. A semiconductor/insulator/graphene heterostructure can inject electrons into the conduction band of the insulator, where an electric field "heats" them up so that the effective emission barrier seen by the "hot" electrons is negative, enabling a voltage-tunable NEA surface. Here, we have experimentally demonstrated a peak emission current density of 2.

The Impact of the Competition on miRNA, Proteins, and Metabolites in the Blood Exosomes of the Horse.

Purpose: Horse racing may cause stress-induced physiological changes and tissue damage in horses, but the changes in miRNA expression, protein expression, and metabolic substances in the plasma exosomes of the horse after racing are still unclear. This study detected miRNA, protein expression, and metabolic substances in the plasma exosomes of horses before and after competition, providing new insights for post-race recovery and care of horses.

Method: Eight three-year-old horses that had undergone training were selected as the research subjects, with four horses that had not competed as the control group and four horses that had participated in the competition for half an hour as the training group.

Effects of Combined Transcriptome and Metabolome Analysis Training on Athletic Performance of 2-Year-Old Trot-Type Yili Horses.

Objectives: Training is essential for enhancing equine athletic performance, but the genetic mechanisms that regulate athletic performance are unknown. Therefore, this paper aims to identify candidate genes and metabolic pathways for the effects of training on equine athletic performance through multi-omics analyses.

Methods: The experiment selected 12 untrained trot-type Yili horses, which underwent a 12-week professional training program.

Transcription factor KUA1 positively regulates tomato resistance against Phytophthora infestans by fine-tuning reactive oxygen species accumulation.

Tomato is a horticultural crop of global significance. However, the pathogen Phytophthora infestans causing the late blight disease imposes a severe threat to tomato production and quality. Many transcription factors (TFs) are known to be involved in responses to plant pathogens, however, the key TFs in tomato resistant to P.

Attention-augmented multi-domain cooperative graph representation learning for molecular interaction prediction.

Accurate identification of molecular interactions is crucial for biological network analysis, which can provide valuable insights into fundamental regulatory mechanisms. Despite considerable progress driven by computational advancements, existing methods often rely on task-specific prior knowledge or inherent structural properties of molecules, which limits their generalizability and applicability. Recently, graph-based methods have emerged as a promising approach for predicting links in molecular networks.

Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway.

Aim: Pyroptosis is a type of programmed cell death characterized by pro-inflammatory activity and is an important factor in pre-eclampsia (PE). Trimethylamine N-oxide (TMAO) is a gut microbial metabolite closely associated with pyroptosis and PE. This study aims to investigate the role of TMAO in trophoblast cell pyroptosis and explore possible mechanisms.

Effective intervention measures to improve the ethical sensitivity of nurses and nursing students.

Aim: The aim of this study is to explore and integrate educational measures and teaching methods designed to enhance ethical sensitivity, with the goal of developing a cohesive and practical reference framework for nursing administrators and educators.

Background: In recent years, ethical sensitivity has garnered increasing attention. While many intervention studies addressing ethical sensitivity have been conducted, there is currently no systematic review that consolidates and integrates the various intervention strategies and teaching methods.

[Amount, sources and distribution of protein intake in Chinese adults aged 60 years and above in 15 provinces (autonomous regions and municipalities) in 2018].

Objective: To analyze the amount, sources, and meal distribution of protein intake in Chinese adults aged ≥ 60 in 15 provinces(autonomous regions and municipalities) in 2018.

Methods: A multistage, random cluster design was employed in China Health and Nutrition Survey in 2018. A total of 4941 participants aged ≥60 years were included in the analysis.

Blood-Based Whole-Genome Methylation Analysis of Yili Horses Pre- and Post-Racing.

This study aims to analyze the whole-genome DNA methylation differences in Yili horses before and after racing, with the goal of identifying differentially methylated genes associated with racing performance and exploring the epigenetic mechanisms underlying exercise in horses. Blood samples were collected from the jugular veins of the top 3 Yili horses in a 5000 m race, which included 25 competitors, both prior to and within 5 min after the race. Genomic DNA was extracted, followed by sequencing using Whole-Genome Bisulfite Sequencing (WGBS) to assess DNA methylation levels, differentially methylated regions (DMRs), and differentially methylated genes (DMGs).

Estimation of genetic parameters of body conformation and racing performance traits in Yili horses.

The Yili horse is a riding-type breed that has been continuously bred independently in China. The genetics of body conformation and racing performance traits need to be comprehensively considered in making breeding decisions. This study is the first to estimate the genetic parameters of 13 body conformation and racing performance traits in Yili horses using a linear model.

PmiProPred: A novel method towards plant miRNA promoter prediction based on CNN-Transformer network and convolutional block attention mechanism.

It is crucial to understand the transcription mechanisms of miRNAs, especially considering the presence of peptides encoded by miRNAs. Since promoters function as the switch for gene transcription, precisely identifying these regions is essential for fully annotating miRNA transcripts. Nonetheless, existing computational methods still have room for improvement in the characterization of promoter regions.

Adaptive changes in balance control strategies under continuous exposure to visual-somatosensory conflicts.

Human postural control system has the capacity to adapt to balance-challenging perturbations. However, the characteristics and mechanisms of postural adaptation to continuous perturbation under the sensory conflicting environments remain unclear. We aimed to investigate the functional role of oscillatory coupling drive to lower-limb muscles with changes in balance control during postural adaptation under multisensory congruent and incongruent environments.

Evaluating pathological complete response as an surrogate endpoint for long-term survival in patients with non-small cell lung cancer: a systematic review and meta-analysis.

Purpose: Pathologic complete response (pCR) is deemed to associate with event-free survival (EFS) and overall survival (OS), however, whether it is suitable to serve as a surrogate endpoint for long-term survival in clinical trials of neo-adjuvant treatment for resectable NSCLC trials is still controversy. We aim to evaluate the role of pCR and its viability as a surrogate endpoint for EFS and OS in NSCLC.

Methods: To investigate the association of pCR and EFS and OS, we performed a meta-analysis involving randomized clinical trials that have reported complete information on pCR rates with hazard ratios (HRs) for EFS and OS.

Pembrolizumab versus sintilimab in patients with advanced NSCLC: a retrospective multicenter study with propensity-score matching analysis.

Background: Programmed cell death protein 1 (PD-1) inhibitors are commonly used worldwide for the management of non-small cell lung cancer (NSCLC). However, it remains unclear whether pembrolizumab and sintilimab, two of the most widely used PD-1 inhibitors in China, have significantly different effects on patients with NSCLC. A multicenter retrospective cohort study was designed and implemented using propensity-score matching (PSM) analysis to compare the effectiveness and safety profiles of pembrolizumab and sintilimab in patients with advanced NSCLC undergoing comprehensive therapy.

Indole-3-Carboxaldehyde Inhibits Inflammatory Response and Lipid Accumulation in Macrophages Through the miR-1271-5p/HDAC9 Pathway.

Indole-3-carboxaldehyde (ICA), a microbiota-derived tryptophan metabolite, has been reported to protect against atherosclerosis. However, the molecular mechanisms for its atheroprotective effect remain largely unknown. This study aimed to explore the influence of ICA on lipid accumulation and inflammatory response in THP-1 macrophage-derived foam cells.

Comprehensive physiological, transcriptomic, and metabolomic analyses revealed the regulation mechanism of evergreen and cold resistance of Pinus koraiensis needles.

As a significant fruit and timber tree species among conifers, Pinus koraiensis remains it evergreen status throughout the harsh winters of the north, a testament to its intricate and prolonged evolutionary adaptation. This study delves into the annual trends of physiological indicators, gene expression levels, and metabolite accumulation to dissect the seasonal adaptability of P. koraiensis needles.

Green synthesized nanoscale zero-valent iron impregnated tea residue biochar efficiently captures metal(loid)s for sustainable water remediation.

Pristine or modified nanoscale zero-valent iron (nZVI) synthesized though conventional chemical reduction have been widely recommended for remediating metal(loid)-contaminated water. However, their eco-friendliness is often challenged with the concomitant bio-toxicity and secondary environmental risks. Alternatively, this study utilized waste tea leaves extract and remaining residue as the reducing agent and pyrolytic matrix to innovatively fabricate a green synthesized nZVI impregnated tea residue biochar (G-nZVI/TB).

Construction and evaluation of a model for efficient identification of photothermal sensitivity of tobacco cultivars based on agronomic traits.

The photothermal sensitivity of tobacco refers to the degree to which tobacco responds to changes in light and temperature conditions in its growth environment, which is crucial for determining the planting area of cultivars and improving tobacco yield and quality. In order to accurately and effectively evaluate the photothermal sensitivity of tobacco cultivars, this study selected five cultivars and their hybrid combinations with significant differences planted under different ecological conditions from 2021 to 2022 as materials. The experiment was conducted in two locations with significant differences in temperature and light.

A genome-wide association study of the racing performance traits in Yili horses based on Blink and FarmCPU models.

Racing performance traits are the main indicators for evaluating the performance and value of sport horses. The aim of this study was to identify the key genes for racing performance traits in Yili horses by performing a genome-wide association study (GWAS). Breeding values for racing performance traits were calculated for Yili horses (n = 827) using an animal model.

The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats.

An increasing number of traditional Chinese medicine(TCM) have been confirmed to possess analgesic bioactivity. 701 Dieda Zhentong patch(701-DZP) which includes 14 kinds of TCMs exhibited excellent efficacy in alleviating back or leg pain after a soft-tissue injury. In this study, UPLC/MS was used to construct the fingerprint of 701-DZP and excavate the potential bioactive ingredients of it.

Comparison of Postoperative Outcomes between Leadless and Conventional Transvenous Pacemakers Implantation: An Up-to-Date Meta-analysis.

Background: Leadless cardiac pacemakers (LCPs) are emerging as viable alternatives to conventional transvenous pacemakers (TVPs). This study aimed to systematically compare the postoperative outcomes of LCPs and TVPs based on available published studies.

Methods: We conducted a systematic review and meta-analysis of literature comparing outcomes from LCP and TVP implantations.

Development and validation of a potential risk area identification model for hand, foot, and mouth disease in metropolitan China.

Maximum Entropy model (MaxEnt), as a machine learning algorithm, is widely used to identify potential risk areas for emerging infectious diseases. However, MaxEnt usually overlooks the influence of the optimal selection of spatial grid scale and the optimal combination of factor information on identification accuracy. Furthermore, the internal level information of factors is closely related to the potential risk of disease occurrence but is rarely applied to enhance MaxEnt's accuracy.