Visualization of Hg Stress on Plant Health at the Subcellular Level Revealed by a Highly Sensitive Fluorescent Sensor.

The presence of Hg causes substantial stress to plants, adversely affecting growth and health by disrupting cell cycle divisions, photosynthesis, and ionic homeostasis. Accurate visualization of the spatiotemporal distribution of Hg in plant tissues is crucial for the management of Hg pollution; however, the related research is still at its early stage. Herein, a small-molecule amphiphilic fluorescent probe (termed ) was developed for the specific detection of Hg with a high sensitivity (~16 nM).

Coffee drinking timing and mortality in US adults.

Background And Aims: To identify the patterns of coffee drinking timing in the US population and evaluate their associations with all-cause and cause-specific mortality.

Methods: This study included 40 725 adults from the National Health and Nutrition Examination Survey 1999-2018 who had complete information on dietary data and 1463 adults from the Women's and Men's Lifestyle Validation Study who had complete data on 7-day dietary record. Clustering analysis was used to identify patterns of coffee drinking timing.

Effect of Acrylate Emulsion on the Mechanical and Microscopic Properties of Straw Fiber-Reinforced Cement-Magnesium Slag Stabilized Soil.

In order to investigate the mechanism of mechanical performance enhancement and the curing mechanisms of acrylate emulsion (AE) in cement and magnesium slag (MS) composite-stabilized soil (AE-C-M), this study has conducted a comprehensive analysis of the compressive strength and microstructural characteristics of AE-C-M stabilized soil. The results show that the addition of AE significantly improves the compressive strength of the stabilized soil. When the AE content is 0.

Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury.

Background And Aims: Cell-cycle-related and expression elevated protein in tumor (CREPT, also named RPRD1B) is highly expressed in tumors and functions to promote tumorigenesis. However, the role of CREPT in the pathophysiology of acute liver injury is limited. Here, we demonstrate that CREPT plays an essential role during acute liver injury.

Correction: Hussain et al. An Epidemiological Survey Regarding Ticks and Tick-Borne Diseases among Livestock Owners in Punjab, Pakistan: A One Health Context. 2021, , 361.

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A Dual-Branch Residual Network with Attention Mechanisms for Enhanced Classification of Vaginal Lesions in Colposcopic Images.

Vaginal intraepithelial neoplasia (VAIN), linked to HPV infection, is a condition that is often overlooked during colposcopy, especially in the vaginal vault area, as clinicians tend to focus more on cervical lesions. This oversight can lead to missed or delayed diagnosis and treatment for patients with VAIN. Timely and accurate classification of VAIN plays a crucial role in the evaluation of vaginal lesions and the formulation of effective diagnostic approaches.

Novel Ultrasonic Pretreatment for Improving Drying Performance and Physicochemical Properties of Slices During Radio Frequency Vacuum Drying.

To enhance the physicochemical quality, drying efficiency, and nutrient retention of dried products, this study investigated the effects of ultrasonic pretreatment on the radio frequency vacuum (RFV) drying characteristics, microstructure, and retention of natural active substances in slices. The ultrasonic time, power, and frequency were considered as experimental factors. The results showed that, compared with conventional RFV drying, ultrasonic pretreatment reduced the drying time of slices by 20-60 min.

Perturbational Decomposition Analysis for Quantum Ising Model with Weak Transverse Fields.

This work presents a perturbational decomposition method for simulating quantum evolution under the one-dimensional Ising model with both longitudinal and transverse fields. By treating the transverse field terms as perturbations in the expansion, our approach is particularly effective in systems with moderate longitudinal fields and weak to moderate transverse fields relative to the coupling strength. Through systematic numerical exploration, we characterize parameter regimes and evolution time windows where the decomposition achieves measurable improvements over conventional Trotter decomposition methods.

Strategies to prevent postoperative delirium: a comprehensive evaluation of anesthesia selection and drug intervention.

Postoperative delirium (POD) represents a common neurological complication encountered predominantly among the elderly cohort undergoing surgical intervention for hip fractures. This phenomenon, particularly commonplace in geriatric populations with heightened preoperative risk profiles, pronounced comorbidities, and later stages of lifespan, poses complex clinical challenges. The impact of perioperative pharmacological interventions and anesthetic strategies on POD's emergence cannot be understated, as it may profoundly affect the length of hospital stays, rehabilitation milestones, and the overall mortality hazard.

The P-type ATPase gene AHA5 is involved in proanthocyanidins accumulation in Medicago truncatula.

Proanthocyanidins (PAs) are the second most abundant plant phenolic natural products. The proton membrane H-ATPase (AHA) is required for PA transportation in vacuoles, but it remains unclear which AHA gene(s) encode tonoplast proton pump in M. truncatula.

Subthalamic nucleus oscillations during facial emotion processing and apathy in Parkinson's disease.

Background: Parkinson's disease (PD) is primarily characterized by motor symptoms, but patients also experience a relatively high prevalence of non-motor symptoms, including emotional and cognitive impairments. While the subthalamic nucleus (STN) is a common target for deep brain stimulation to treat motor symptoms in PD, its role in emotion processing is still under investigation. This study examines the subthalamic neural oscillatory activities during facial emotion processing and its association with affective characteristics.

New Insights into the Ion/Electron Transfer Mechanisms of LiMnO-Based Membrane Electrodes at Different Electron Fluxes.

Electrochemical Li extraction technology is a highly promising approach for Li extraction from salt lakes. To enhance its practical application, it is crucial to elucidate the ion/electron transfer mechanism under diverse process conditions particularly different electron fluxes. Different migration intermediate states demonstrate the distinct ion migration mechanisms inside the LiMnO lattice at different electron fluxes.

Syringa oblata Lindl Extract Alleviated Corticosterone-Induced Depression via the cAMP/PKA-CREB-BDNF Pathway.

Ethnopharmacological Relevance: Syringa oblata Lindl (ZDX) is a plant in the Oleaceae family that is the primary ingredient in the classic Tibetan medicine AKARU sinensis. The plant's stem is used as a medicine, and Tibetan doctors often use it as a sedative, a use with a history of nearly 100 years. Tibetan medicine mainly uses lilac to treat headache, forgetfulness, insomnia, irritability and other symptoms.

The changes in the ratio of Dicer1 transcripts can participate in the neuronal hypoxic response by regulating miR-29b.

The nervous system is highly dependent on the supply of oxygen and nutrients, so when demand for oxygen exceeds its supply, hypoxia is induced. The hippocampus is very important in the nervous system. It has the ability to control human behavior, memory, emotion, and so on.

LIPUS promotes osteogenic differentiation of rat BMSCs and osseointegration of dental implants by regulating ITGA11 and focal adhesion pathway.

Background: Low-intensity pulsed ultrasound (LIPUS) has been used as an effective noninvasive method for treating fractures and osteoarthrosis, but the application in the field of oral implantation is in its infancy. This study aimed to clarify the effect and mechanism of LIPUS on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and implant osseointegration, and to provide an experimental basis for future clinical applications.

Methods: Dental implants were inserted into Wistar rat femurs, and LIPUS was performed for 4 weeks.

LncRNA-MEG3/miR-93-5p/SMAD7 axis mediates proliferative and inflammatory phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis.

Synovial hyperplasia, inflammation and immune cell infiltration are the central pathological basis of rheumatoid arthritis (RA). Nonetheless, the cellular, molecular and immunological mechanisms of RA remain poorly understood. An integrated analysis of single-cell RNA (scRNA) and bulk RNA sequencing datasets‌ aimed to unravel the cellular landscape, differentiation trajectory, transcriptome signature, and immunoinfiltration feature of RA synovium.

Elevating VAPB-PTPIP51 integration repairs damaged mitochondria-associated endoplasmic reticulum membranes and inhibits lung fibroblasts activation.

Long-term silica exposure to silica dust leads to irreversible pulmonary fibrosis, during which lung fibroblast activation plays an essential role. Mitochondria-associated endoplasmic reticulum membranes (MAMs) is a structural interface for communication between the outer mitochondrial membrane and the endoplasmic reticulum. VAPB-PTPIP51 is a key complex on MAMs.

Deposition history of polycyclic aromatic hydrocarbons in tibetan lakes indicate the effectiveness of protected area establishment.

The effectiveness of protected areas in mitigating human impacts remains uncertain due to limited in-situ data; however, atmospheric micropollutant deposition in alpine lakes may provide a quantitative approach to evaluate anthropogenic pressures and threats. In this study, the temporal changes of polycyclic aromatic hydrocarbons (PAHs) inside/outside the Siling Co protected area, Tibet were reconstructed. The varying anthropogenic impact history suggested that, unlike the dominance of residential activities (i.

ENO1 promotes PDAC progression by inhibiting CD8 T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling.

Metabolic reprogramming is a hallmark of cancer. The"Warburg effect", also known as aerobic glycolysis, is an essential part of metabolic reprogramming and a central contributor to cancer progression. Moreover, hypoxia is one of the significant features of pancreatic ductal adenocarcinoma (PDAC).

Diagnosis of lymph node metastasis in oral squamous cell carcinoma by an MRI-based deep learning model.

Background: Cervical lymph node metastasis (LNM) is a well-established poor prognosticator of oral squamous cell carcinoma (OSCC), in which occult metastasis is a subtype that makes prediction challenging. Here, we developed and validated a deep learning (DL) model using magnetic resonance imaging (MRI) for the identification of LNM in OSCC patients.

Methods: This retrospective diagnostic study developed a three-stage DL model by 45,664 preoperative MRI images from 723 patients in 10 Chinese hospitals between January 2015 and October 2020.

ATGL regulates renal fibrosis by reprogramming lipid metabolism during the transition from AKI to CKD.

Acute kidney injury (AKI) can progress to chronic kidney disease (CKD) and subsequently to renal fibrosis. Poor repair of renal tubular epithelial cells (TECs) after injury is the main cause of renal fibrosis. Studies have shown that restoring damaged fatty acid β-oxidation (FAO) can reduce renal fibrosis.

Sensitive and accurate photoluminescent-multiphonon resonant Raman scattering dual-mode detection of microRNA-21 via catalytic hairpin assembly amplification and magnetic assistance.

A novel dual-mode detection method for microRNA-21 was developed. Photoluminescent (PL) and multiphonon resonant Raman scattering (MRRS) techniques were combined by using ZnTe nanoparticles as signal probes for reliable detection. The catalytic hairpin assembly (CHA) strategy was integrated with superparamagnetic FeO nanoparticle clusters (NCs) to enhance sensitivity.

Generative adversarial synthetic neighbors-based unsupervised anomaly detection.

Anomaly detection is crucial for the stable operation of mechanical systems, securing financial transactions, and ensuring network security, among other critical areas. Presently, Generative Adversarial Networks (GANs)-based anomaly detection methods either require labeled data for semi-supervised learning or face challenges with low computational efficiency and poor generalization when dealing with complex distributions. Aim to address these limitations, we introduce a generative adversarial synthetic neighbors-based unsupervised anomaly detection (GASN) method.

Gate-Controlled Superconducting Switch in GaSe/NbSe van der Waals Heterostructure.

The demand for low-power devices is on the rise as semiconductor engineering approaches the quantum limit, and quantum computing continues to advance. Two-dimensional (2D) superconductors, thanks to their rich physical properties, hold significant promise for both fundamental physics and potential applications in superconducting integrated circuits and quantum computation. Here, we report a gate-controlled superconducting switch in GaSe/NbSe van der Waals (vdW) heterostructure.