Atomically Precise Ternary Cluster: Polyoxometalate Cluster Sandwiched by Gold Clusters Protected by N-Heterocyclic Carbenes.

Coinage metal (Au, Ag, Cu) cluster and polyoxometalate (POM) cluster represent two types of subnanometer "artificial atoms" with significant potential in catalysis, sensing, and nanomedicine. While composite clusters combining Ag/Cu clusters with POM have achieved considerable success, the assembly of gold clusters with POM is still lagging. Herein, we first designedly synthesized two cluster structural units: an AuO cluster stabilized by diverse N-heterocyclic carbene (NHC) ligands and an amine-terminated POM linker.

Droplet Impact on Superhydrophobic Mesh Surfaces.

Reducing the contact time of droplet impacts on surfaces is crucial for various applications including corrosion prevention and anti-icing. This study aims to explore a novel strategy that greatly reduces contact time using a superhydrophobic mesh surface with multiple sets of mutually perpendicular ridges while minimizing the influence of the impacting location. The effects of the impact Weber numbers and ridge spacing on the characteristics of the impact dynamics and contact time are studied experimentally.

X-ray-triggered through-space charge transfer and photochromism in silver nanoclusters.

Materials exhibiting X-ray-induced photochromism have consistently piqued the interest of researchers. Exploring the photochromic properties of such materials is valuable for understanding the structural changes and electron transfer processes that occur under high energy radiation, such as X-ray irradiation. Here, a crystalline silver(I) nanocluster synthesized from -butylacetylene silver was found to have the ability to exhibit color and photoluminescence changes upon exposure to X-ray radiation.

Post-synthesis functionalization of ZIF-90 with sulfonate groups for high proton conduction.

Introducing sulfonic acid groups into MOF materials is one of the effective approaches to enhance proton conduction. Here, we attempted to prepare a new post-modified ZIF-90-based material by addition reaction of the aldehyde group with bisulfite to obtain partially functionalized ZIF-90-SONa. ZIF-90-SONa exhibits a high proton conductivity of 2.

Chiral {NiPW} Cluster-Organic Framework: Synthesis, Structure, and Properties.

A chiral three-dimensional polyoxometalate cluster-organic framework (POMCOF) H[(btc)Ni(μ-OH)(HO)(B-α-PWO)]·17HO (, btc = 1,2,4-benzenetricarboxylate) has been made under hydrothermal conditions in the absence of amine or chiral starting reagents. shows high stability in CHCN/DMF (1:3), acidic, and basic solutions with the pH ranging from 2 to 12 for 5 days. The UV-vis reflectance spectra and Mott-Schottky measurements reveal that could be a suitable catalyst for photocatalysis.

{Cu} Cluster-Sandwiched Polyoxotungstates and Their Polymers: Syntheses, Structures, and Properties.

Four inorganic-organic hybrid octa-Cu cluster sandwiched polyoxotungstates (POTs), [Cu(HO)(en)(B-α-HSiWO)] (), [Cu(HO)(en)(B-α-HGeWO)] (), K[Cu(en)(B-α-HSiWO)]·6HO (), and K[Cu(en)(B-α-HGeWO)]·2HO () (en = ethylenediamine), were hydrothermally made and characterized by single-crystal X-ray diffraction, infrared spectra, powder X-ray diffraction, and thermogravimetric analysis, respectively. Structure analysis reveals that the polyoxoanion of / is a discrete dimer built by two trivalent Keggin [B-α-XWO] (X = Si/Ge) fragments and one octa-Cu cluster, whereas and display a two-dimensional network built by octa-Cu-sandwiched POT units via substitution of coordinated water on polyanions of and and further expand into a three-dimensional framework via K cation bridges. Ultraviolet-visible diffuse reflectance spectra reveal that are potential semiconductor materials.

[Effects of topical application of doxycycline on avulsed permanent teeth].

Purpose: To evaluate the treatment effect of topical doxycycline on avulsed permanent teeth compared with normal saline.

Methods: A total of 44 avulsed teeth from 38 patients (22 boys and 16 girls, aged 7-14 years) were recruited. Twenty-one teeth in group A were treated with doxycycline for 5 min before replantation while 23 teeth in group B were treated with saline solution.

A case report of cholangiocarcinoma combined with moderately differentiated gastric adenocarcinoma.

Rationale: Multiple primary carcinoma (MPM) refers to simultaneous or successive occurrence of ≥2 types of primary malignant tumors in a single organ or in different organs of the same individual. It is rarely seen in clinical practice. Among the various types of MPM, hilar cholangiocarcinoma combined with gastric cancer is extremely rare.

[Effects of silencing Rce1 in vitro on the invasion and migration of tongue carcinoma].

Objective: This study aimed to explore the influence of Rce1 on invasion and migration of tongue squamous cell carcinoma cells by silencing the Rce1 gene with RNA interference.

Methods: The tongue squamous cell carcinoma Cal-27 and SCC-4 cells were cultured in vitro. The small interfering RNA (siRNA) of the Rce1 gene was designed, and the Rcel gene expression was silenced vialiposome transfection.

Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3.

Background: Pancreatic cancer is a highly invasive malignant tumor. Expression levels of the autophagy-related protein microtubule-associated protein 1A/1B-light chain 3 (LC3) and perineural invasion (PNI) are closely related to its occurrence and development. Our previous results showed that the high expression of LC3 was positively correlated with PNI in the patients with pancreatic cancer.

MicroRNAs Involved in the Regulation of LC-PUFA Biosynthesis in Teleosts: miR-33 Enhances LC-PUFA Biosynthesis in Siganus canaliculatus by Targeting insig1 which in Turn Upregulates srebp1.

Post-transcriptional regulatory mechanisms play important roles in the regulation of LC-PUFA biosynthesis. Our previous study revealed that miR-33 could increase the expression of fatty acyl desaturases (fads2) in the rabbitfish Siganus canaliculatus, but the specific mechanism is unknown. Here, we confirmed that miR-33 could target the 3'UTR of insulin-induced gene 1 (insig1), resulting in downregulation of its protein level in the rabbitfish hepatocyte line (SCHL).

Enantiomeric Polyoxometalates Based on Malate Chirality-Inducing Tetra-Zr-Substituted Keggin Dimeric Clusters.

On the basis of the synergistic strategy of lacunary polyoxometalate structure-directing function and chiral ligand inducting role, two pairs of enantiomeric polyoxotungstates, (NH)(TMA)[Zr(μ-O)(l-/d-mal)(B-α-HSiWO)] (TMA = tetramethylammonium, mal = malate (CHO); l-mal for 1a, d-mal for 1b) and (NH)(TMA)[Zr(μ-O)(l-/d-mal)(B-α-PWO)] (l-mal for 2a, d-mal for 2b), and a mesomeric polyoxotungstate, (NH)NaK[Zr(μ-O)(l-mal)(d-mal)(B-α-SiWO)] (3), were hydrothermally synthesized. 1a, 2a and 1b, 2b respectively exhibit 1-D 2 right- and left-hand helical chains formed by hydrogen-bonding interactions, and 3 forms a 3-D (3,10)-connected framework by Na/K ions with {4.6.

Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity.

Chronic stress, a causal factor for depression, can also cause cognitive impairments and tau pathology. However, whether and how the selective serotonin reuptake inhibitor antidepressant escitalopram ameliorates these effects are still unclear. In the present study, rats were subjected to chronic mild unpredictable stress for 8 weeks.

[Analgesic Effect of Induced by Needling at Sanyinjiao (SP 6) Acupoint on Primary Dysmenorrheal Patients with Cold Damp Stagnation Syndrome].

Objective: To observe the analgesic effect of induced by needling at Sanyinjiao (SP 6) on primary dysmenorrheal (PD) patients with cold damp stagnation syndrome (CDSS).

Methods: A total of 64 PD patients with CDSS experiencing abdominal pain (≥40 mm in visual analogue scale ，VAS) were randomly assigned into -expectation(DE) group(＝15) and no--expectation(NDE) group(＝49). On the first day of abdominal pain attack, bilateral SP 6 were punctured respectively with thicker needles with deeper insertion for -expectation patients and thin filiform needles with shallow insertion for no--expectation patients.

Synchronous double primary malignancies of the liver and kidney: A case report.

A 42-year-old male patient was admitted to the Department of General Surgery of The First Affiliated Hospital of Henan University of Science and Technology (Luoyang, China) presenting with abdominal discomfort. Enhanced computed tomography of the abdomen revealed a 15.1×7.

LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice.

More than 50% of multiple sclerosis patients develop cognitive impairment. However, the underlying mechanisms are still unclear, and there is no effective treatment. LINGO-1 (LRR and Ig domain containing NOGO receptor interacting protein 1) has been identified as an inhibitor of oligodendrocyte differentiation and myelination.

Mechanistic studies of cyclin-dependent kinase inhibitor 3 (CDKN3) in colorectal cancer.

Colorectal cancer is one of the most severe subtypes of cancer, and has the highest propensity to manifest as metastatic disease. Because of the lack of knowledge of events that correlate with tumor cell migration and invasion, few therapeutic options are available. The current study aimed to explore the mechanism of colorectal cancer in hope of identifying the ideal target for future treatment.

Beneficial effect of splanchnic nerve transection and harmful effect of vagotomy on acute necrotizing pancreatitis in the dog.

Background: The nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. However, the influence of visceral nerve (VN) on acute necrotizing pancreatitis (ANP) has drawn little attention.

Aim: To investigate the influence of VN on the pathophysiological process of ANP in dogs.

Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis.

Aim: To investigate the expression of microRNA-218 (miR-218) in serum from gastric cancer patients and its relationship with clinicopathological characteristics.

Methods: A total of 68 patients with pathologically diagnosed gastric cancer and 56 healthy individuals were recruited to this study. The expression of miR-218 was detected in the serum of gastric cancer patients and healthy individuals by quantitative real-time polymerase chain reaction.

Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis.

Aim: To investigate effects of perirenal space blocking (PSB) on gastrointestinal function in patients with severe acute pancreatitis (SAP).

Methods: Forty patients with SAP were randomly allocated to receive PSB or no PSB (NPSB). All the SAP patients received specialized medical therapy (SMT).

[Analgesic effect of acupuncture at Neimadian(Extra) in postoperation of abdominal surgery].

Objective: To observe the analgesia effectiveness and safety of electroacupuncture at Neimadian(Extra) for postoperation of abdominal surgery.

Methods: One hundred and twenty patients with routine abdominal surgery were randomly divided into an acupuncture group and a medication group, 60 cases in each group. The acupuncture group was treated with electroacupuncture at Neimadian(Extra), which was located on the inside of lower leg, 7 cun above the internal malleolus and 0.