Publications by authors named "Jun Hui Luo"
Renal interstitial fibrosis is a final pathway that is observed in various types of kidney diseases, including diabetic kidney disease (DKD). The present study investigated the effect of tranilast on renal interstitial fibrosis and the association between its role and mast cell infiltration in a rat model of DKD. A total of 30 healthy 6‑week‑old male Sprague‑Dawley rats were randomly divided into the following four groups: Normal control group; DKD model group; low‑dose tranilast group (200 mg/kg/day); and high‑dose tranilast group (400 mg/kg/day).
View Article and Find Full Text PDFNorcantharidin (NCTD) was shown in our previous studies to attenuate renal tubulointerstitial fibrosis in rat models with diabetic nephropathy (DN). The aim of this study was to determine the effects of NCTD on the expression of extracellular matrix (ECM) and TGF-β1 in HK-2 cells stimulated by high glucose and on calcineurin (CaN)/NFAT pathway. Whether or not the antifibrotic effect of NCTD on renal interstitium was dependent on its inhibition of CaN pathway was also investigated.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how NCTD (norcantharidin) affects the growth and fibronectin expression in HK-2 kidney cells exposed to albumin.
- HK-2 cells were categorized into groups: control, albumin, and those treated with various NCTD concentrations, to assess cell proliferation and fibronectin levels.
- Results showed that NCTD reduced both cell growth and fibronectin expression compared to the albumin group, suggesting its potential role in preventing kidney damage related to proteinuria.
Objective: To investigate the effects of norcantharidin (NCTD) on tubulointerstitial fibrosis of diabetic nephropathy (DN) in streptozotocin-induced rat model.
Methods: Sprague-Dawley rats were randomly divided into control group, model group, low-dose NCTD (0.05 mg/kg/day) group, and high-dose NCTD (0.
Background: p75NTR has been used to isolate esophageal and corneal epithelial stem cells. In the present study, we investigated the expression of p75NTR in esophageal squamous cell carcinoma (ESCC) and explored the biological properties of p75NTR+ cells.
Methods: p75NTR expression in ESCC was assessed by immunohistochemistry.