Exposure-response analysis of drug-induced QT interval prolongation in telemetered monkeys for translational prediction to human.

Introduction: The preclinical in vivo assay for QT prolongation is critical for predicting torsadogenic risk, but still difficult to extrapolate to humans. This study ran preclinical tests in cynomolgus monkeys on seven QT reference drugs containing the drugs used in the IQ-CSRC clinical trial and applied exposure-response (ER) analysis to the data to investigate the potential for translational information on the QT effect.

Methods: In each of six participating facilities in the J-ICET project, telemetered monkeys were monitored for 24 h following administration of vehicle or 3 doses of test drugs, and pharmacokinetic profiles at the same doses were evaluated separately.

Influence of pre-laminated material on shock absorption ability in specially designed mouthguard with hard insert and space.

Purpose: We have developed a new type of laminated mouthguard, the Hard & Space mouthguard, which incorporates a hard material insert and a space to prevent contact between the mouthguard and the buccal surfaces of the teeth. The purpose of this study was to investigate the effect of this new design on shock absorption.

Methods: Three types of mouthguard (a conventional laminated EVA mouthguard and two 3-layer type "Hard & Space" mouthguards made of 1.

Functional near-infrared spectroscopy study on primary motor and somatosensory cortex response to biting and finger clenching.

The purpose of this study was to compare the influence of biting and finger clenching intensity on the concentration of oxygenated hemoglobin (OxyHb) in regional cerebral blood flow (rCBF) as an indicator of brain activity in the primary motor (MI) and somatosensory (SI) cortices. Functional near-infrared spectroscopy (fNIRS) was used in 8 healthy subjects. Subjects were required to do biting (bite) and finger clenching (fclench) at 20, 50 and 80% of maximum force.

Are all mouthguards the same and safe to use? Part 2. The influence of anterior occlusion against a direct impact on maxillary incisors.

The purpose of this study was to clarify the influence anterior occlusion, of mouthguards, has on protecting against a direct collision to the maxillary anterior teeth. In other words, the support mandibular dentition has when wearing a mouthguard. Two types of mouthguards were used for this study, one with an appropriate anterior occlusion or a mouthguard with positive anterior occlusion (MGAO+) and another which was a single-layer mouthguard lacking the same occlusion or a mouthguard with negative anterior occlusion (MGAO-) but with the same thickness on the buccal side.

Does hard insertion and space improve shock absorption ability of mouthguard?

Mouthguards are expected to reduce sports-related orofacial injuries. Numerous studies have been conduced to improve the shock absorption ability of mouthguards using air cells, sorbothane, metal wire, or hard material insertion. Most of these were shown to be effective; however, the result of each study has not been applied to clinical use.

[Questionnaire survey of dentists who made their own mouthguards].

Purpose: Most of the mouthguards on the market are inferior in fit and occlusion related to feeling and injury prevention capacity. Therefore, it is necessary to use appropriate custom-made mouth-guards. This research aimed to obtain data for the selection, improvement, and spread of mouthguards in the future.

[Mouthguard effect of tooth distortion during clenching].

Purpose: A mouthguard can protect stomatognathic systems from traumatic damage. However, severe occlusal wear of teeth and loss of teeth have often been found in players clinically. These problems might originate in strong clenching during sports.

Can mouthguards prevent mandibular bone fractures and concussions? A laboratory study with an artificial skull model.

Some sports' accidents are responsible for inflicting traumatic brain injuries and mandibular bone fractures when impacts occur to the chin. It is often thought that mouth guards can prevent many of these injuries. However, such assertions may be insufficient without adequate research.

The influence of the sensor type on the measured impact absorption of mouthguard material.

Mouthguards have been tested for impact energy absorption using drop-ball and/or pendulum devices. While all reports show efficiency of the mouthguard, the impact absorption abilities reported differ considerably. This difference has been attributed to differences of mouthguard material, design, and the impact force used.