SLC4A7 suppresses lung adenocarcinoma oncogenesis by reducing lactate transport and protein lactylation.

Lactate and protein lactylation serve a key role in tumor pathogenesis. Solute carrier 4A7 (SLC4A7), a key transporter, participates in cellular acid homeostasis. However, its impact on lactate transport and protein lactylation in solid tumors, particularly lung adenocarcinoma (LUAD), remains largely unexplored.

Preparation of capecitabine-poly(p-dioxanone) electrospraying nanoparticles and influence of particle size on their colorectal cancer inhibitive efficiency.

Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.

Bench Surgery with Robot-assisted Kidney Autotransplantation for Complex Kidney Tumors: Technique and Outcomes from a Single Center.

Background And Objective: Bench surgery (BenS) with kidney autotransplantation serves as an alternative to nephron-sparing surgery (NSS) for patients harboring high-complexity renal tumors that are ineligible for in situ partial nephrectomy (PN). However, the experience of BenS with robot-assisted kidney autotransplantation (RAKAT) has been scarce in such cases. Here, we describe the operative techniques, and functional and oncological outcomes of BenS with RAKAT.

Classifying schizophrenia using functional MRI and investigating underlying functional phenomena.

Background: Existing studies have revealed functional abnormalities in certain brain regions of patients with schizophrenia (SZ), but the relationships between these abnormalities and their impact on disease progression remain unclear.

Methods: Fifty-six patients with SZ and 56 healthy controls were included. Based on resting-state functional magnetic resonance imaging, we analyzed fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and degree centrality (DC).

Effects of engineering injection and supplement mode of in-situ biogeochemical transformation enhancement EVO-FeSO on the remediation of tetrachloroethylene contaminated aquifer.

Traditional in situ biogeochemical transformation suffers from competition among crucial microorganisms and inadequate formation of reactive minerals, thus leading to the accumulation of toxic intermediates. In this study, three regulation schemes were proposed to solve these problems from the perspective of engineering mode. Results showed intermittent injection mode effectively reduced the accumulation of toxic intermediates but the reduction rate of tetrachloroethylene was decreased.

Effect of polyhexamethylene biguanide-coated central venous catheters on bacterial colonization in cancer patients undergoing abdominal surgery: a randomized controlled trial.

Background: Central venous catheters (CVCs) are widely used in critically ill patients, including cancer patients, but are associated with complications such as catheter-related bloodstream infections (CRBSIs). This study evaluates the effectiveness of polyhexamethylene biguanide (PHMB)-coated CVCs in reducing catheter-tip bacterial colonization in cancer patients undergoing abdominal surgery.

Methods: A prospective, randomized, monocentric clinical trial was conducted at Peking University Cancer Hospital from March 2017 to April 2019.

Heterointerface with Continuous Channels Enables Fast Na Transport in Layered NaTiO.

High-power sodium-ion batteries are essential for grid energy storage; however, they are generally limited by Na transport. Herein, we tailor a highly matched heterostructure (MgTiO@NaTiO) via a facile in situ synthesis method. The similar crystal structures of NaTiO and MgTiO creat continuous Na diffusion channels at the heterointerface, and the interactions at the interface creat a built-in interface electric field with a direction from MgTiO to NaTiO.

Feasibility exploration of myocardial blood flow synthesis from a simulated static myocardial computed tomography perfusion via a deep neural network.

Background:: Myocardial blood flow (MBF) provides important diagnostic information for myocardial ischemia. However, dynamic computed tomography perfusion (CTP) needed for MBF involves multiple exposures, leading to high radiation doses.

Objectives:: This study investigated synthesizing MBF from simulated static myocardial CTP to explore dose reduction potential, bypassing the traditional dynamic input function.

Electroacupuncture inhibits oxidative stress and improves cognitive function by downregulating the Ang II/AT1R/NOX axis in chronic cerebral ischemia rats.

Objective: This study aimed to explore the effects of Electroacupuncture (EA) on chronic cerebral ischemia (CCI).

Methods: A CCI rat model was established by blocking the common carotid arteries. Model rats were treated with EA at the "Baihui" (GV20) and "Dazhui" (GV14) acupoints and/or ARB.

Effects of Blood Pressure Management Based on Non-Invasive Heart Function Monitoring on Reducing Postoperative Hypotension in Elderly Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial.

Background: Postoperative hypotension is a common symptom in elderly patients undergoing total knee arthroplasty (TKA), which is associated with intraoperative blood pressure (BP) management. The study aimed to explore the causes of perioperative hypotension in TKA elderly patients and analyze the effects of BP management strategies based on noninvasive heart function monitoring on reducing postoperative hypotension.

Methods: A total of 176 elderly TKA patients were divided into four groups: the tourniquet group (group T), the nontourniquet group (group N), the goal-oriented BP management tourniquet group (group GT), and the goal-oriented BP management nontourniquet group (group GN).

Controllable dual-pulse laser directly for nonlinear photoacoustic microscopy.

Nonlinear photoacoustic microscopy (PAM) usually requires dual-pulse excitation. Current approaches to realize dual-pulse laser train are indirect, mainly based on beam combinations. Here, we report a compact (∼5-cm-long cavity) laser source that directly outputs controllable nanosecond (∼34 ns) dual pulses, including the tunability of repetition rate (0-20 kHz), time delay (5-30 µs), and relative intensity ratio (20-500%), perfectly matching the requirements of nonlinear imaging in PAM.

Basic Considerations for Data Pooling Strategy in Multi-Regional Clinical Trials (MRCTs).

The National Medical Products Administration of China has been implementing ICH E17, which describes the general principles for planning and designing of multi-regional clinical trials (MRCTs), yet there are several ambiguities in the execution and conduct remains in China or East Asia. In specific, pooling strategy, effect modifiers (EMs), statistical analysis, sample size allocation and their impact in alignment with global trial remains a challenge. In this paper, we explore on the criteria mentioned above under the context of China.

Encapsulated FeC boosted electrocatalytic performance for oxygen reduction reaction of N-doped carbon nanotube.

The shortcomings of precious metal based catalysts have limited the development of novel energies. So, developing low-cost and high performance transition metal based catalysts is one of the most feasible way to substitute the precious metal based catalysts. In all of the developed catalysts for oxygen reduction reactions (ORR), the iron-based nitrogen doped carbon nanotube (N-CNT) show great promise.

p62 Binding to Protein Kinase C Regulates HIV-1 gp120 V3 Loop Induced Microglial Inflammation.

The main pathogenic mechanism of HIV-associated neurocognitive disorders (HAND) is neuronal apoptosis induced by inflammatory mediators, in which microglial inflammation plays a crucial role. However, the exact pathogenic mechanism remains unclear. Previous studies have shown that the HIV-1 gp120 V3 loop can trigger inflammation in CHME-5 microglia.

Switch-Type Electrochemiluminescence Aptasensor for AFB1 Detection Based on CoS Quantum Dots Encapsulated in Co-LDH and a Ferrocene Quencher.

Among the various aflatoxin B1 (AFB1) assays, performing accurate detection is difficult because false positives and false negatives are frequent due to limited sensitivity, expensive equipment, or inadequate pretreatment during operation. Here, an "off-on" switch-type electrochemiluminescence (ECL) aptasensor armed with cobalt-sulfur quantum dots was encapsulated in hollow cobalt-layered double hydroxide nanocages as an enhanced luminescent probe (Co-LDH@QDs), and a ferrocene-modified aptamer (Fc-APT) was used as a luminescent quencher. In general, when Fc-APT was hybridized with complementary DNA modified with a DNA nanotetrahedron, electron transfer between ferrocene and Co-LDH@QDs was facilitated, leading to efficient quenching of the ECL intensity into an "off" state in the absence of AFB1.

Multi-perspective kinetic analysis of plastic blends under thermogravimetric pyrolysis conditions.

Plastic blends were co-pyrolyzed under non-isothermal conditions in a thermogravimetric (TG) analyzer. The co-pyrolysis characteristics and kinetic triplet, i.e.

Prognostic analysis of elective neck dissection in cT3/T4a/T4bN0 maxillary sinus squamous cell carcinoma.

Purpose: This study aimed to examine the effect of elective neck dissection (END) on the prognosis of patients with cT3/T4N0 maxillary sinus squamous cell carcinoma (MSSCC).

Methods: Data were obtained from the SEER database. Patients with cT3/T4a/T4bN0 MSSCC were included in the study and divided into two groups: those who received END treatment and those who did not.

Microfluidics-based automatic immunofluorescence staining for single-molecule localization microscopy.

Full automation of single-molecule localization microscopy (SMLM) is crucial for large-scale and high-throughput cellular imaging. It is well-known that SMLM typically consists of three major steps: immunofluorescence (IF) staining, optical imaging, and image processing. Currently, automation in optical imaging and image processing is almost complete; however, the automation of IF staining has been slow to advance, probably due to its complicated experimental operations.

Efficacy of neoadjuvant therapy and lymph node dissection in advanced gallbladder cancer without distant metastases: a SEER database analysis.

Purpose: To investigate the effectiveness of neoadjuvant therapy and lymph node dissection(LND) on overall survival (OS) in patients with stage III/IV gallbladder cancer without distant metastases.

Methods: Data from 101 patients who received neoadjuvant therapy followed by surgery combined with adjuvant chemotherapy, and 1412 patients who received direct surgical treatment followed by adjuvant chemotherapy, were collected from the SEER database from 2004 to 2020. Patients were divided into group A (neoadjuvant therapy) and group B (direct surgery) based on the treatment modality.

Shear wave elastography based analysis of changes in fascial and muscle stiffness in patients with chronic non-specific low back pain.

Background: The quantitative assessment of individual muscle and fascial stiffness in patients with low back pain remains a challenge. This study aimed to compare the stiffness of the thoracolumbar fascia (TLF), erector spinae (ES), and multifidus (MF) in patients with and without chronic non-specific low back pain (CNLBP) using shear wave elastography (SWE). It also sought to explore the relationship between muscle and fascial stiffness and the levels of pain and dysfunction in patients with CNLBP.

Bias control for optical single-sideband transmitter based on single IQ modulator.

The optical in-phase and quadrature modulator (IQM) is typically utilized as an optical single-sideband (SSB) transmitter for its simple structure and low cost. It requires the modulator biases to be slightly offset for generating the optical carrier. However, this poses significant challenges in the bias control circuits, as most off-the-shelf automatic bias control (ABC) modules are designed to stabilize the IQM at its carrier suppression point for coherent optical communication.

Compatible metasurface for ultra-wideband radar and switchable infrared stealth.

In response to the rapid advancements in radar detection technology and the widespread deployment of infrared sensors, single-function stealth materials are increasingly challenged to meet the sophisticated demands of concealment within complex electromagnetic environments. As a result, there is a pressing need for research into metamaterial structures that can simultaneously deliver ultra-wideband radar stealth and controllable infrared invisibility. Here, a novel metamaterial structure was proposed and realized, comprising vertically integrated infrared stealth and radar stealth layers, with the aim of accomplishing both ultra-wideband radar stealth and controlled infrared invisibility.

CRISPR-based molecule-regulatory expression platform for specific immunotherapy of cancer.

Introduction: Cancer is still a major challenge of human health. The abnormality of intracellular cancer-related signal pathways is an important mechanism for the occurrence of cancer.

Methods: We used a molecular-senor to act on the endogenous signal molecules within the cell to redirect the abnormal signal flows in the cell to treat cancer.

Novel phase transfer catalysis coupled with bifunctional oxidation for enhanced remediation of groundwater polluted with multiple NAPL: Performance and mechanisms.

Structural differences among non-aqueous phase liquids (NAPLs) result in varying oxidation rates, limiting mass transfer between NAPLs and oxidants and seriously impairing the effectiveness of remediation via traditional in-situ chemical oxidation. To tackle this challenge, a novel approach is proposed for remediating multi-NAPL-polluted groundwater that leverages phase transfer catalysis (PTC) to enhance heterogeneous mass transfer by transferring oxidants from groundwater to NAPLs. Meanwhile, "oxidation-in-situ activation" is achieved through bifunctional oxidation using permanganate and peroxymonosulfate (PP).