Publications by authors named "Jun Do"

In this paper, we demonstrate a blazed phase grating to achieve tunable beam steering and propose a novel algorithm to reduce the stripe noise in wrapped phase. To control the diffraction angle to steer light to the desired direction, an electrically tunable transmission-type beam deflector based on liquid crystals is introduced, and electric fields are applied to the patterned indium tin oxide electrodes to change its phase retardation. Two different 2π phase-wrapping methods are applied to obtain various diffraction angles within the minimum cell-gap, and the method of equal interval of phase achieves a worthwhile diffraction efficiency compared to the methods based on equal interval of diffraction angle.

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Recombinant GH16B β-agarase-catalyzed liquefaction of 5-7 %(w/v) melted agarose at 50 °C completely hydrolyzed agarose into neoagarohexaose (NA6) and neoagarotetraose (NA4). Subsequent saccharification by recombinant GH50A β-agarase or recombinant GH50A β-agarase/recombinant GH117A α-neoagarobiose hydrolase at 35 °C converted NA6/NA4 into neoagarobiose (NA2) or 3,6-anhydro-L-galactose (L-AHG)/D-galactose, respectively. Purification of NA6/NA4 and NA2 was achieved by Sephadex G-15 column chromatography, while L-AHG was purified by Sephadex G-10, achieving ≥ 98 % purity.

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: Although the risk of serious bleeding following peritoneal dialysis catheter insertion is low, pericannular bleeding can increase the risk of catheter-related infections and reduce catheter survival. We aimed to analyze the risk factors for bleeding complications during peritoneal dialysis catheter insertion and assess whether temporary preemptive hemodialysis before catheterization can reduce bleeding and improve catheter survival. : We retrospectively analyzed bleeding complications and catheter survival in patients who underwent temporary hemodialysis prior to peritoneal dialysis catheter insertion.

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Article Synopsis
  • - The study examined the survival benefits of automated peritoneal dialysis (APD) compared to continuous ambulatory peritoneal dialysis (CAPD), focusing on the effects of using icodextrin, with 148 patients categorized into four groups based on their treatment type over one year.
  • - Results indicated that the use of icodextrin in CAPD (CAPD+ET) had better patient survival rates than APD without icodextrin (APD-ET), although the differences were not statistically significant, particularly among non-diabetic patients.
  • - The findings suggest that APD without icodextrin may lead to poorer patient and technique survival due to challenges in volume control, particularly highlighted by a higher edema index
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  • Oxidative stress and mitochondrial dysfunction are important factors in neurodegenerative diseases, with glutathione (GSH) being a crucial antioxidant in the brain.
  • A study explored the role of L-cysteine (L-Cys) in protecting mouse hippocampal neuronal cells from damage and apoptosis caused by reactive oxygen species (ROS) induced by a specific compound (DMNQ).
  • L-Cys showed the ability to prevent oxidative damage and improve cognitive function in mice, indicating its potential as a neuroprotective agent, despite not directly boosting GSH levels in the presence of another GSH synthesis inhibitor (BSO).
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Epithelial-to-mesenchymal transition (EMT) is considered as one of the senescence processes; reportedly, antisenescence therapies effectively reduce EMT. Some models have shown antisenescence effects with the use of sodium-glucose cotransporter 2 (SGLT2) inhibitor. Therefore, our study investigated the antisenescence effects of empagliflozin as an SGLT2 inhibitor in a peritoneal fibrosis model and their impact on EMT inhibition.

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Article Synopsis
  • The study investigated the relationship between changes in pre-haemodialysis serum creatinine levels and long-term survival in patients undergoing chronic haemodialysis over two years.
  • Patients were categorized into three groups based on their serum creatinine changes: stable, increasing, and decreasing, with mortality rates analyzed for each group.
  • Results indicated that the decreasing group had the highest risk of mortality, while the increasing group had a lower mortality risk compared to the stable group, highlighting the importance of monitoring serum creatinine levels for patient survival.
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Background: The guidelines recommended target and minimum single-pool / are 1.4 and 1.2, respectively, in hemodialysis patients.

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: We evaluated the impact of warfarin use on the clinical outcomes of patients with atrial fibrillation who were undergoing hemodialysis (HD). : A retrospective analysis was conducted utilizing data from patients undergoing maintenance HD who participated in HD quality assessment programs. Patients who were assigned the diagnostic code for atrial fibrillation (n = 4829) were included and divided into two groups based on the use of warfarin: No group (no warfarin prescriptions (n = 4009)), and Warfarin group (warfarin prescriptions (n = 820)).

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Background: Previous studies have reported inconsistent results regarding the advantages or disadvantages of spironolactone use in patients undergoing hemodialysis (HD). This study aimed to evaluate survival according to the use of spironolactone in a large sample of patients undergoing maintenance HD.

Methods: This retrospective study used laboratory and clinical data from the national HD Quality Assessment Program and claims data.

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Background: This study aimed to evaluate the patient survival rates based on the use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) in a large cohort of patients undergoing maintenance hemodialysis (HD).

Methods: Data from a national HD quality assessment program were used in this retrospective study. The patients were classified into four groups based on the use of renin-angiotensin system blockers (RASBs) as follows: No group, patients without a prescription of any anti-hypertensive drugs including RASBs; Other group, patients with a prescription of anti-hypertensive drugs excluding RASBs; ACEI group, patients with a prescription of an ACEI; and ARB group, patients with a prescription of an ARB.

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Introduction: Results on the association between the use of renin-angiotensin system blockades (RASBs) and vascular access-related outcomes are inconsistent. We aimed to compare vascular access-related outcomes according to the use of RASBs in hemodialysis patients.

Methods: This study used data from a national hemodialysis quality assessment program of the Republic of Korea (n = 54,903).

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Data to draw definite conclusions regarding the association between proton pump inhibitor (PPI) and all-cause mortality in patients undergoing hemodialysis (HD) remain insufficient. The object of this retrospective study was to assess the impact of PPIs on patient survival within a substantial cohort of individuals receiving maintenance HD. To achieve this, the study employed laboratory and clinical data sourced from the 4th, 5th, and 6th National HD Quality Assessment Programs.

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Introduction: There were insufficient pieces of evidence regarding the effect of the two drugs (allopurinol and febuxostat) on patient survival in hemodialysis (HD) patients. Herein, we aimed to compare the efficacy of uric acid-lowering drugs (ULDs) or the type of the drug on patient survival using a representative sample of maintenance HD patients in South Korea.

Methods: This study used data from a national HD quality assessment program and the claims data.

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Additional studies are needed to confirm whether the use of renin-angiotensin system blockers (RASBs) induces survival benefits in patients on hemodialysis (HD). This study aimed to evaluate patient survival with the use of RASBs in a large sample of maintenance HD patients. This study used data from the national HD quality assessment program and claim data from South Korea ( = 54,903).

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The association between sarcopenia and obesity in peritoneal dialysis (PD) patients is more complex than that of the general population. The aim of this study was, therefore, to evaluate the association of patient survival with sarcopenia or sarcopenic components and obesity in groups of patients with PD. We retrospectively analyzed a dataset from 199 prevalent PD patients.

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This study aimed to evaluate the difference in patient survival according to the type of erythropoiesis-stimulating agent (ESA) treatment used in the Korean hemodialysis (HD) population. This retrospective study analyzed the laboratory data from a national HD quality assessment program and the claims of Korea. Included participants were divided into three groups according to the type of ESA used during the 6 months of each assessment period as follows: the EP group (n = 38,043, epoetin-α or epoetin-β), the DP group (n = 10,054, darbepoetin-α), and the MR group (2253, continuous erythropoietin receptor activator).

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There were few data regarding the association of volume status with sarcopenia using muscle mass, strength, and physical performance in non-dialysis chronic kidney disease (ND-CKD) patients. We aimed to evaluate the association between volume status and sarcopenia in ND-CKD patients. Our retrospective study analyzed data from a previous study which included ND-CKD patients who had stable renal function.

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Many peritoneal dialysis (PD) patients are malnourished, which leads to weakening owing to a decrease in muscle mass. However, this straightforward association could differ based on the sex of individuals. Further, studies on the sex-based association among nutrition, muscle mass, and strength would be helpful in choosing optimal interventions to improve the strength of patients on dialysis.

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: Few studies have investigated the association between muscle mass and bone mineral density (BMD) in patients undergoing peritoneal dialysis (PD). We aimed to investigate the association between muscle mass or strength and BMD in patients undergoing PD. Methods: The data of all prevalent PD cases at a tertiary medical center between September 2017 and November 2020 were collected.

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This study aimed to evaluate and compare the usefulness of four indices-arm circumference, thigh circumference, mid-arm muscle circumference (MAMC), and thigh muscle circumference (TMC)-with that of other classical indicators of body composition in the prediction of sarcopenia and two sarcopenia-related components in patients receiving peritoneal dialysis (PD) grouped by sex. The data of all patients receiving PD who visited a tertiary medical center were collected (n = 214); of them 199 patients undergoing PD were included in the final analyses. Data on baseline characteristics and measurements, including circumferences of appendicular sites, handgrip strength (HGS), and appendicular lean mass (ALM) index, were obtained during a routine peritoneal membrane equilibration test.

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Background: Further studies are needed to identify whether muscle mass, muscle strength, or sarcopenia is the best indicator of survival in patients undergoing peritoneal dialysis (PD). We aimed to compare the association of sarcopenia and its components with survival in patients undergoing PD.

Methods: We identified all patients with PD (n = 199).

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Background: Neck circumference (NC), per se, includes muscle mass beyond simple fat mass and mainly subcutaneous fat. We aimed to investigate the clinical usefulness of NC for predicting muscle mass, strength, or sarcopenia in patients undergoing peritoneal dialysis (PD).

Methods: We retrospectively analyzed the data of patients undergoing PD (n = 199).

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Purpose: As the number of patients with chronic kidney disease increases, nephrologist activities are gradually expanding. This study evaluated the safety and success of peripherally inserted central catheter (PICC) performed by nephrologists.

Patients And Methods: We retrospectively analyzed the medical records of a medical center.

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Background: Tunnel exposure, a non-infectious complication, is a rare finding in peritoneal dialysis (PD) patients, which has been described in some case reports. Our study aimed to present catheter salvage therapy using a revision procedure of tunnel exposure by nephrologists.

Methods: Our retrospective study was conducted between July 1998 and October 2021.

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