Theoretical Prediction of Enhanced Hydrogen Evolution Reaction Electrocatalysts Based on Tantalum Phosphide.

Ta-based transition metal catalysts have shown significant catalytic activity for the hydrogen evolution reaction (HER) in recent studies. However, the application of tantalum phosphide (TaP) in the HER has not been documented. Herein, a systematic study of TaP catalysts was performed through density functional theory (DFT).

Design and Synthesis of C-Symmetric Axially Chiral β-Aryl Porphyrins and Application for Supporting Ir(III)-Catalyzed Enantioselective C-H Alkylation.

A hitherto unknown class of C-symmetric C-C (C, C, C, C) axially chiral porphyrins has been synthesized and the application of their iridium (Ir) complexes in catalytic asymmetric C(sp)-H functionalization is documented. Cyclotetramerization of enantioenriched axially chiral 2-hydroxymethyl-3-naphthyl pyrroles under mild acidic conditions affords, after oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), the C-symmetric α,α,α,α-atropenantiomer as an only isolable diastereomer. Both regioisomeric Ir(Por*)(CO)(Cl) complexes catalyze the carbene C-H insertion reaction affording the same enantiomer, albeit with slight difference in enantioselectivity.

Enantioselective Construction of Chiral Cyclopropa[]coumarins via Lewis Base-Catalyzed Cyclopropanation.

The first highly enantioselective construction of chiral cyclopropa[]coumarins was described. Using commercially available (bis)cinchona alkaloid (DHQ)PYR as the chiral Lewis base catalyst, together with CsCO as the achiral base, the reaction of a series of coumarin-3-carboxylate and 3-benzoyl coumarins with -butyl 2-bromoacetate could give rise to the corresponding cyclopropa[]coumarins bearing three continuous chiral stereocenters in 83-93% ee and 90-97% ee, respectively. The reaction is proposed to proceed via an generated ammonium ylide intermediate.

Analysis of Immune Responses in Mice Orally Immunized with Recombinant pMG36e-SP-TSOL18/ and pMG36e-TSOL18/ Vaccines of .

Cysticercosis is a cosmopolitan zoonotic parasitic disease infected by larval of (). Several drugs for the treatment of cysticercosis, such as praziquantel, albendazole, and mebendazole, have certain toxicity and side effects. Considering that there is no vaccine available, we studied a new vaccine for cysticercosis in this study.