Publications by authors named "Jun Chan Ren"
Article Synopsis
- - The study aimed to investigate how simulated weightlessness affects the electrical properties of neurons in the dorsal root ganglion (DRG) of rats, particularly focusing on changes in their excitability and conduction mechanisms.
- - Researchers created a model of weightlessness through hindlimb unloading and measured neuronal activity using techniques like whole-cell patch-clamp recordings and conduction velocity assessments.
- - Results indicated that rats experienced longer action potentials and decreased conduction velocities in DRG neurons, alongside findings that suggest these changes could lead to impaired motor performance.
The present study aimed to study the changes of neurotrophin-3 (NT-3) expression of intrafusal muscle fibers in rat soleus muscles under simulated weightlessness. The tail-suspension (SUS) rat model was used to simulate weightlessness. Forty mature female Sprague-Dawley rats were randomly assigned to ambulatory control (CON), 3-day SUS, 7-day SUS, 14-day SUS and 21-day SUS groups.
View Article and Find Full Text PDFInfluence of 14-day hind limb unloading on isolated muscle spindle activity in rats.
J Muscle Res Cell Motil
September 2010
During hind limb unloading (HU), the soleus is often in a shortened position and the natural physiological stimulus of muscle spindles is altered, such that muscle spindle activity also changes. Using isolated spindle conditions, the present study investigates the electrophysiological activity and ultrastructure of muscle spindles following HU. Results show that muscle spindle discharges fall into either of two main patterns, single spikes or spike clusters in shortened positions, with a steady frequency of 18-38 spikes/s (mean 29.
View Article and Find Full Text PDF[Influence of 100 Hz sinusoidal vibration on muscle spindle afferents of soleus muscles in suspended situation rat].
Space Med Med Eng (Beijing)
October 2004
Objective: To study influence of 100 Hz sinusoidal vibration on muscle spindle afferents discharges of rat soleus muscles in simulated-weightlessness situation.
Method: The tail-suspended rat model was used to simulate weightlessness, and 100 Hz sinusoidal vibration was performed by a vibrator. Unit activity was recorded electrophysiologically from the centrally cut filaments of the spinal dorsal roots innervating muscle spindles of the rat soleus muscle; then observation on the changes in afferent discharges from muscle spindle in a rat soleus muscles were made after 7 d.