Study on the Influence of Au Content and Bonding Parameters on the Free Air Ball Morphology and Bonding Reliability of Ag-Au-Pd Alloy Wire.

This article conducts wire bonding tests and cold/hot-cycle tests using φ 0.025 mm Ag-Au alloy wires and Ag-Au-Pd alloy wires with different specifications. The results show that, due to the addition of the alloying element Pd, under the same bonding parameters, the fracture strength and ball-bonded point shear force of the Ag-Au-Pd alloy wires are significantly higher than those of the Ag-Au alloy wires.

Atezolizumab plus bevacizumab in patients with unresectable or metastatic mucosal melanoma: 3-year survival update and multi-omics analysis.

Background: Atezolizumab plus bevacizumab has shown promising efficacy in advanced mucosal melanoma in the multi-centre phase II study. This report updates 3-year survival outcomes and multi-omics analysis to identify potential response biomarkers.

Methods: Forty-three intention-to-treat (ITT) patients received intravenous administration of atezolizumab and bevacizumab every 3 weeks.

Estimating forest aboveground carbon sink based on landsat time series and its response to climate change.

Accurately estimating forest carbon sink and exploring their climate-driven mechanisms are critical to achieving carbon neutrality and sustainable development. Fewer studies have used machine learning-based dynamic models to estimate forest carbon sink. The climate-driven mechanisms in Shangri-La have yet to be explored.

The community dynamic alterations mechanisms of traveling plastics in the Pearl River estuary with the salinity influence.

Most ocean plastics originate from terrestrial emissions, and the plastisphere on the plastics would alter during the traveling due to the significant differences in biological communities between freshwater and marine ecosystems. Microorganisms are influenced by the increasing salinity during traveling. To understand the contribution of plastic on the alteration in biological communities of plastisphere during traveling, this study investigated the alterations in microbial communities on plastics during the migration from freshwater to brackish water and saltwater.

"From Waste to Wonder": Comparative Evaluation of Chinese Cabbage Waste and Banana Peel Derived Hydrogels on Soil Water Retention Performance.

Under the increasing severity of drought issues and the urgent need for the resourceful utilization of agricultural waste, this study aimed to compare the soil water retention properties of hydrogels prepared from Chinese cabbage waste (CW) and banana peel (BP) using grafting techniques with acrylic acid (AA) and acrylamide (AAm). Free radical polymerization was initiated with ammonium persulfate (APS), and N, N'-methylene bisacrylamide (MBA) served as the crosslinking agent to fabricate the grafted polymer hydrogels. The hydrogels were subjected to detailed evaluations of their water absorption, reusability, and water retention capabilities through indoor experiments.

Photoinduced SF degradation for deoxyfluorination of propargyl alcohols.

Deoxyfluorination is one of the most practical methods for introducing fluorine atoms, since hydroxyl groups are commonly found in organic small molecules. Traditional fluorination methods often rely on hazardous fluorinating reagents. Herein, we report the deoxyfluorination of propargyl alcohols using sulfur hexafluoride (SF) as a safe fluorinating agent under photocatalytic conditions.

Identification of potential biomarkers for hepatocellular carcinoma based on machine learning and bioinformatics analysis.

Metastasis is the major cause of hepatocellular carcinoma (HCC) mortality. But the effective biomarkers for HCC metastasis remain underexplored. Here we integrated GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) datasets to screen candidate genes for hepatocellular carcinoma metastasis, a consensus metastasis-derived prognostic signature (MDPS) was constructed by machine learning.

A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.

Objectives: To explore the potential role of oral bacteria in the pathogenesis of burning mouth syndrome (BMS).

Materials And Methods: Fifteen patients with BMS and 15 healthy controls were enrolled in this study. The relative abundance and diversity of salivary bacterial strains were analyzed using metagenomic DNA sequencing.

An antigen/chemotherapy co-loaded DNA nanocube inserts into tumor cell plasma membrane and enhances chemo- and immunotherapy.

Breast cancer is the most frequently diagnosed female cancer. Combined chemo- and immunotherapies have been extensively explored to treat breast cancer. To improve the efficacy of the combined therapies, this study designed a hollow DNA nanocube with four cholesterol anchors (C2.

Engineered collagen/PLLA composite fillers to induce rapid and long-term collagen regeneration.

Injectable subcutaneous fillers are used in medical aesthetics primarily to correct skin wrinkles. The limitations of collagen fillers include rapid degradation, lack of collagen regeneration effects and high-frequency injections. The regenerative filler of Sculptra (Aesthetic) offers prolonged regenerative effects; however, the slow collagen regeneration results in prolonged waiting time for the filling effects.

Multidimensional stress and self-harm in Chinese preadolescents: A cross-sectional study.

Background: Limited research has been conducted on self-harm among preadolescents in China. This study investigated the influence of multidimensional stress on high levels of self-harm behavior in preadolescents.

Method: This large-scale cross-sectional study of 7-14-year-old primary school students in grades 3-6 was conducted in Southwest China between September and December 2020.

Clinicopathological characteristics, evolution, and treatment outcomes of hormone receptor-negative/HER2-low metastatic breast cancer: a pooled analysis of individual patient data from three prospective clinical trials.

Objective: With the approval of trastuzumab deruxtecan for the treatment of unresectable/metastatic HER2-low breast cancer, human epidermal growth factor receptor 2 (HER2)-low has emerged as a clinically actionable biomarker. There is an urgent need for a deeper understanding of HER2-low breast cancer patients. Therefore, this study was conducted to explore the clinicopathological characteristics, the evolution of HER2-low status, and its impact on the prognosis of hormone receptor (HoR)-negative/HER2-low metastatic breast cancer (MBC) patients.

Radioresistance-related gene signatures identified by transcriptomics characterize the prognosis and immune landscape of pancreatic cancer patients.

Background: Radiotherapy (RT) is an important means of local treatment of solid tumors, and radioresistance is the main reason for RT failure for tumors, especially pancreatic cancer (PC). It is urgent to distinguish key genes and mechanisms of radioresistance in PC.

Methods: We acquired the data from The Cancer Genome Atlas (TCGA), obtained the gene modules associated with radioresistance by weighted gene coexpression network analysis (WGCNA), and identified differentially expressed genes (DEGs) between normal and tumor samples.

Combination mechanism and dimethyl ether removal performance of organic-bound water in kitchen waste.

Dewatering plays an important role in kitchen waste reduction and resource utilization; however, the mechanism of water combination and removal remains unclear. In this study, dimethyl ether solvent was used to investigate the water occurrence state and dewatering pattern in kitchen waste, and the key organic components, hydrophilic functional groups, and water removal mechanism were clarified. The results showed that all the water existed in the state of organic-bound water, in which proteins were the key organic matters affecting dewatering and the hydrophilic functional groups CO/CN, CO, and amine-N.

Nursing students' bullying experiences from instructors and nurses in the clinical practice: A qualitative systematic review and meta-synthesis.

Objectives: Nursing students are more prone to bullying from clinical instructors and registered nurses during clinical practice than on campus. This bullying has physical and psychological effects on them, but it receives less attention. This review integrated qualitative studies of bullying by instructors or nurses experienced by nursing students during their clinical practice.

Theoretical study on the thermal decomposition mechanism of 2-nitro-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine.

Context: High nitrogen and high-density compounds have become popular research objects in the energetic materials in recent years. Among them, compounds composed of triazine and azole skeleton rings have received attention due to their good stability and nitrogen content. The triazine imidazole-based condensed ring energetic derivatives have good properties and lack research on the direction of thermal decomposition.

Degradation of PARP1 by MARCHF3 in tumor cells triggers cCAS-STING activation in dendritic cells to regulate antitumor immunity in hepatocellular carcinoma.

Background: Resistance to immune checkpoint inhibitors (ICIs) significantly limits the efficacy of immunotherapy in patients with hepatocellular carcinoma (HCC). However, the mechanisms underlying immunotherapy resistance remain poorly understood. Our aim was to clarify the role of membrane-associated ring-CH-type finger 3 (MARCHF3) in HCC within the framework of anti-programmed cell death protein-1 (PD-1) therapy.

Predicting the risk of malaria importation into Jiangsu Province, China: a modeling study.

Background: The World Health Organization certified China malaria-free in 2021. Consequently, preventing the risk of malaria re-introduction caused by imported malaria has now become a major challenge. This study aims to characterize the dynamics and predict the risk of malaria importation in Jiangsu Province, where the number of imported malaria cases ranks among the highest in China.

How hand-made affects consumers' perceived nutritional quality of organic food.

This study analyzed the impact of handmade in depth on consumers' perceived nutritional quality of organic food through three experiments. Experiment 1 found that handmade significantly enhanced consumers' positive perceptions of nutritional quality of organic food. Experiment 2 revealed the mediating role of handicraft cultural identity between handmade and perceived nutritional quality.

Uncovering protein regulation during adventitious root formation in Platycladus orientalis cuttings.

Cell totipotency and pluripotency are the cellular basis for root regeneration in Platycladus orientalis (L.) Franco cuttings, and the regeneration of adventitious roots is a key determinant for improving stem-cutting. However, the cellular basis and physiological regulation of adventitious root formation are still ambiguous.

Integrating enzyme-nanoparticles bring new prospects for the diagnosis and treatment of immune dysregulation in periodontitis.

Enzymes play a significant role in mediating inflammatory and immune responses in periodontitis. Effective diagnosis, timely treatment, and continuous management of periodontal enzymes are essential to prevent undesirable consequences; however, this remains a significant challenge. Nanoparticles (NPs) have attracted significant attention in biomedicine because of their advantageous nanosized effects.

Crystalline/Amorphous Interface Engineering and d-sp Orbital Hybridization Synergistically Boosting the Electrocatalytic Performance of PdCu Bimetallene toward Formic Acid-Assisted Overall Water Splitting.

Advanced electrocatalysts capable of bifunctional catalysis for formic acid oxidation (FAOR) and hydrogen evolution reaction (HER) have garnered significant attention due to their exceptional energy efficiency. In this research, we have meticulously designed a PdCu bimetallene characterized by numerous crystalline/amorphous (c/a) interfaces and robust d-sp orbital hybridization, achieved by integrating the p-block metalloid boron within the PdCu matrix (B-PdCu-c/a). The B-PdCu-c/a bimetallene revealed a multitude of surface atoms and unsaturated defect sites, offering abundant catalytic active sites and an optimized electronic structure.

Precision Orthodontic Force Simulation Using Nodal Displacement-Based Archwire Loading Approach.

Precision in force simulationis critical for forecasting tooth movement and optimizing orthodontic treatment strategies. While traditional techniques have provided valuable insights, there remains a need for improved methodologies that can seamlessly integrate with fixed orthodontic practices. This study aims to refine orthodontic force simulation techniques by integrating a nodal displacement approach within finite element analysis, specifically designed to enhance prediction accuracy in tooth movement and optimize orthodontic treatment planning.