Elevated serum granzyme B levels are associated with disease activity and joint damage in patients with rheumatoid arthritis.

Objectives: Little is known about the roles of granzyme B in rheumatoid arthritis (RA). We aimed to evaluate the serum level of granzyme B in patients with RA and determine relationships with clinical features and joint destruction of RA.

Methods: We enrolled 100 patients with RA, 50 patients with osteoarthritis (OA), and 50 healthy controls (HC).