Publications by authors named "Jumanah Baig"
Article Synopsis
- Vulvar and vaginal melanomas (VVMs) are rare but serious types of cancer that don't have a lot of standard ways to predict their outcomes.
- A study looked at 79 cases of VVMs over about 26 months and found that certain factors, like tumour necrosis (when the tumor is dying), can indicate how likely a patient is to survive.
- Vaginal melanomas were found to have worse survival rates compared to other types like vulvar or clitoral melanomas, highlighting the need for different treatment plans based on where the cancer is located.
Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions. Alterations in HNF4α isoforms have been associated with tumorigenesis. However, the distribution of its isoforms during progression from dysplasia to malignancy has not been studied, nor has it yet been studied in intraductal papillary mucinous neoplasms, where both malignant and pre-malignant forms are routinely clinically identified.
View Article and Find Full Text PDFBreast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality among women. Two thirds of patients are classified as hormone receptor positive, based on expression of estrogen receptor alpha (ERα), the main driver of breast cancer cell proliferation, and/or progesterone receptor, which is regulated by ERα. Despite presenting the best prognosis, these tumors can recur when patients acquire resistance to treatment by aromatase inhibitors or antiestrogen such as tamoxifen (Tam).
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