Regional Heterogeneity of the Results of Glucagon-Like Peptide 1 Receptor Agonist Trials in Type 2 Diabetes: A Reanalysis of Individual Participant Data.

Objective: Multiregional trials are designed under the assumption that treatment effect applies to the entire target population, yet several factors may introduce geographic heterogeneity in treatment effect. We explored whether such variations exist in trials assessing the efficacy of glucagon-like peptide 1 receptor agonists (GLP-1RAs) in major cardiovascular events (MACE) in type 2 diabetes.

Research Design And Methods: A systematic search of Medline and the Cochrane Library was conducted from inception until 30 June 2020.

Measurement of nonlinear refractive indices of bulk and liquid crystals by nonlinear chirped interferometry.

The nonlinear refractive indices (n) of a selection of bulk (LiBO, KTiOAsO, MgO:LiNbO, LiGaS, ZnSe) and liquid (E7, MLC2132) crystals are measured at 1030 nm in the sub-picosecond regime (200 fs) by nonlinear chirped interferometry. The reported values provide key parameters for the design of near- to mid-infrared parametric sources, as well as all-optical delay lines.

Large-Scale Plasma Proteome Epitome Profiling is an Efficient Tool for the Discovery of Cancer Biomarkers.

Current proteomic technologies focus on the quantification of protein levels, while little effort is dedicated to the development of system approaches to simultaneously monitor proteome variability and abundance. Protein variants may display different immunogenic epitopes detectable by monoclonal antibodies. Epitope variability results from alternative splicing, posttranslational modifications, processing, degradation, and complex formation and possesses dynamically changing availability of interacting surface structures that frequently serve as reachable epitopes and often carry different functions.

Reporting of harms in clinical trials of esketamine in depression: a systematic review.

While previous systematic reviews of trials evaluating conventional antidepressants highlighted inadequacies and inconsistencies in adverse event (AE) reporting, no evaluation is available on esketamine in resistant depression. The objective of this review was to assess quality of reporting AEs in all published clinical trials studying esketamine. It also aimed to compare the proportions of AEs reported in journal articles to those recorded in the ClinicalTrial.

Reconfigurable design of a thermo-optically addressed liquid-crystal phase modulator by a neural network.

We present a machine learning approach to program the light phase modulation function of an innovative thermo-optically addressed, liquid-crystal based, spatial light modulator (TOA-SLM). The designed neural network is trained with a little amount of experimental data and is enabled to efficiently generate prescribed low-order spatial phase distortions. These results demonstrate the potential of neural network-driven TOA-SLM technology for ultrabroadband and large aperture phase modulation, from adaptive optics to ultrafast pulse shaping.

Spectral coherence properties of continuum generation in bulk crystals.

The stability of the phase difference between two white-light continua, generated from the same 180-fs pulses at ≃1035 nm, is assessed by a modified Bellini-Hänsch interferometer. Mutual spectral phase stability is studied and quantified as a function of several parameters: pulse energy, position of the nonlinear crystal with respect to the beam waist and interaction length. Our results show that intrapulse decoherence may significantly contribute to the measured CEP noise floor.

Placebo response in Raynaud's Phenomenon clinical trials: The prominent role of regression towards the mean: Placebo response in Raynaud's Phenomenon.

Background: Substantial placebo response has been observed in trials assessing treatments in Raynaud's Phenomenon (RP), which makes any treatment effect difficult to detect. However, whether this response is due to a real placebo effect or to other nonspecific effects, such as regression towards the mean (RTM), has not been explored. Our objectives were to explore and quantify placebo response in RP, and to evaluate the magnitude of RTM contribution.

Case Report: A Case of Valproic Acid-Induced Hyperammonemic Encephalopathy Associated With the Initiation of Lithium: A Re-duplicable Finding.

Introduction: Hyperammonemic encephalopathy (HAE) is a serious adverse effect of valproate semisodium, which is facilitated by the potential for drug interaction. However, despite frequent co-prescription of valproate semisodium and lithium, the role of this combination in the occurrence of HAE has not been defined in the literature. This case report concerns the occurrence of HAE concomitant with the initiation of lithium in a 29-year-old patient who had been placed on valproate semisodium for a schizoaffective disorder.

LightCue: An Innovative Far-Red Light Emitter for Locally Modifying the Spectral Cue in Outdoor Conditions with Global Consequences on Plant Architecture.

Plasticity of plant architecture is a promising lever to increase crop resilience to biotic and abiotic damage. Among the main drivers of its regulation are the spectral signals which occur via photomorphogenesis processes. In particular, branching, one of the yield components, is responsive to photosynthetic photon flux density (PPFD) and to red to far-red ratio (R:FR), both signals whose effects are tricky to decorrelate in the field.

Case Report: Use of Subcutaneous Midazolam During an Episode of Catatonia.

Midazolam is a benzodiazepine (BZD) mainly used in anesthetic induction due to its pharmacokinetic features. Its place in the therapeutic management of catatonia remains to be determined. Here we present the case of a 65-year-old man who presented with a first episode of catatonia with opposition to any form of oral treatment, where a single dose of 1 mg of subcutaneous (SC) Midazolam permitted clinical improvement allowing oral treatment to be given.

Colorimetry characterization of molecular reorientation transition in thin nematic cells.

The characterization of equilibria and their transition is fundamental in dynamic systems. Experimentally, the characterization of transitions is complex due to time scales separation, the effect of thermal fluctuations, and inherent experimental imperfections. Liquid crystal devices are derived from the manipulation of the molecular reorientation and transition between them by employing external electrical and magnetic fields.

Biomimicry of iridescent, patterned insect cuticles: comparison of biological and synthetic, cholesteric microcells using hyperspectral imaging.

Biological systems inspire the design of multifunctional materials and devices. However, current synthetic replicas rarely capture the range of structural complexity observed in natural materials. Prior to the definition of a biomimetic design, a dual investigation with a common set of criteria for comparing the biological material and the replica is required.

Relativistic-intensity near-single-cycle light waveforms at kHz repetition rate.

The development of ultra-intense and ultra-short light sources is currently a subject of intense research driven by the discovery of novel phenomena in the realm of relativistic optics, such as the production of ultrafast energetic particle and radiation beams for applications. It has been a long-standing challenge to unite two hitherto distinct classes of light sources: those achieving relativistic intensity and those with pulse durations approaching a single light cycle. While the former class traditionally involves large-scale amplification chains, the latter class places high demand on the spatiotemporal control of the electromagnetic laser field.

Dispersion of 20 fs pulses through band edges of cholesteric liquid crystals.

We demonstrate the ability to manipulate ultrashort pulses in cholesteric liquid crystals in the linear regime. We present an extensive analysis of the spectral changes undergone by 20fs pulses when propagating through band edges of cholesteric liquid crystals. The accurate quantification of the introduced optical dispersion opens the way to controlled stretching and compression of ultrashort pulses.

Nanoscale hyperspectral imaging of tilted cholesteric liquid crystal structures.

Ongoing research on chiral liquid crystals takes advantage of the peculiar behavior of twisted structures subject to curvature. We demonstrate the fine tunability of the characteristics of the bandgap of a cholesteric structure in which the orientation of the helix axis spatially changes. To date, the spectral resolution of the order of 6 nm, herein reached by hyperspectral imaging, has not been solved in tilted helices.

A new methodology based on sensitivity analysis to simplify the recalibration of functional-structural plant models in new conditions.

Background And Aims: Functional-structural plant models (FSPMs) describe explicitly the interactions between plants and their environment at organ to plant scale. However, the high level of description of the structure or model mechanisms makes this type of model very complex and hard to calibrate. A two-step methodology to facilitate the calibration process is proposed here.

Shear-enhanced diffraction from thin permanent gratings in dye-doped nematic liquid crystal cells.

Permanent gratings are recorded in planar-aligned dye-doped nematic liquid crystal cells under visible light illumination. By increasing the irradiation intensity and exposure time, several diffraction orders of the recorded gratings are obtained in the Raman-Nath diffraction regime. By applying a dynamic transverse shear on one of the confining plates of the cell, an enhancement of the diffraction efficiency is achieved, which follows the period of the grating.

Dynamical optical response of nematic liquid crystal cells through electrically driven Fréedericksz transition: influence of the nematic layer thickness.

A dynamical optical characterization of planar nematic liquid-crystal cells electrically driven through the Fréedericksz transition is presented. Our method involves applying voltage steps with different starting voltage close to the Fréedericksz threshold. Measurements are performed on cells with various thickness, from a few microns up to 180µm, and highlight the transient molecular disorder occurring close to the Fréedericksz transition.

Tunable angular shearing interferometer based on wedged liquid crystal cells.

The concept of a liquid crystal wedge as a tunable angular shearing interferometer is introduced and demonstrated to combine both high stability and high tunability. Different wedges are fabricated from planar aligned nematic liquid crystal cells with thickness gradients. These wedges are shown to produce stable interferograms from the polarization interference between the ordinary and extraordinary waves propagating in different directions at the output of the cell.

Continuously tunable femtosecond delay-line based on liquid crystal cells.

We introduce a new device for group and phase delay steering of femtosecond pulse trains that makes use of cascaded, electrically driven, nematic liquid-crystal cells. Based on this approach we demonstrate a continuously tunable optical delay line. The simple collinear implementation with no moving parts enables to shape the achievable temporal range with sub-femtosecond accuracy.

Anticorrelated Emission of High Harmonics and Fast Electron Beams From Plasma Mirrors.

We report for the first time on the anticorrelated emission of high-order harmonics and energetic electron beams from a solid-density plasma with a sharp vacuum interface-plasma mirror-driven by an intense ultrashort laser pulse. We highlight the key role played by the nanoscale structure of the plasma surface during the interaction by measuring the spatial and spectral properties of harmonics and electron beams emitted by a plasma mirror. We show that the nanoscale behavior of the plasma mirror can be controlled by tuning the scale length of the electron density gradient, which is measured in situ using spatial-domain interferometry.