Publications by authors named "Julius Wissemann"
Purinergic Signal
June 2024
Article Synopsis
- The NLRP3-inflammasome is a protein complex that promotes inflammation in response to danger signals, with recent research showing that ADP activates this inflammasome in mice through the P2Y receptor.
- Blocking this pathway helped reduce inflammation in mouse models of colitis, but its effects in humans had not been studied.
- In this study, researchers confirmed the activation of the NLRP3-inflammasome by ADP in mouse macrophages, but found no similar activation in human cells, suggesting the mouse signaling pathway does not apply to humans.
