Novel Pinhole Emitter Chip for Micro Supercritical Fluid Chromatography-Mass Spectrometry with Integrated Dilution-Free Fluidic Back-Pressure Regulation.

We present a novel chip-based device featuring a pinhole emitter for mass spectrometry (MS) coupling with integrated fluidic back-pressure regulation for supercritical mobile phases. This design enables facile coupling of packed capillary columns used for supercritical fluid chromatography (SFC) with atmospheric pressure ionization mass spectrometry. The monolithic microfluidic chips were fabricated using selective laser-induced etching, seamlessly integrating multiple functions, including comb-shaped particle retention structures for column packing and ports for zero-clearance connection with standard fused silica capillaries.

Modular Chip-Based nanoSFC-MS for Ultrafast Separations.

This study presents the development of a miniaturized device for supercritical fluid chromatography coupled with mass spectrometry. The chip-based, modular nanoSFC approach utilizes a particle-packed nanobore column embedded between two monolithically structured glass chips. A microtee in the pre-column section ensures picoliter sample loads onto the column, while a microcross chip structure fluidically controls the column backpressure.

Hyperconfined bio-inspired Polymers in Integrative Flow-Through Systems for Highly Selective Removal of Heavy Metal Ions.

Access to clean water, hygiene, and sanitation is becoming an increasingly pressing global demand, particularly owing to rapid population growth and urbanization. Phytoremediation utilizes a highly conserved phytochelatin in plants, which captures hazardous heavy metal ions from aquatic environments and sequesters them in vacuoles. Herein, we report the design of phytochelatin-inspired copolymers containing carboxylate and thiolate moieties.