Tumor necrosis factor-alpha antagonists in patients with complicated spinal tuberculosis: A case series and literature review.

Introduction: Spinal tuberculosis is often associated with poor outcomes; host-directed inflammation involving the spine contributes to this disability.

Methods: A retrospective review of patients with complicated spinal tuberculosis having received tumor necrosis factor-alpha (TNF-α) antagonists at a referral hospital in South Africa. A literature review was performed to identify all published cases of complicated spinal tuberculosis that received a TNF-α antagonist as part of their treatment.