Publications by authors named "Julius Orhalmi"

Background: Anorectal hemangioma is a rare and frequently misdiagnosed cause of lower gastrointestinal (GI) bleeding. Here, we present a minimally invasive therapy with selective embolization.

Case Summary: A 21-year-old male patient experienced painless rectal bleeding since childhood and was treated for ulcerative colitis.

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Background And Aims: Fecal incontinence (FI) improvement following injection of autologous skeletal muscle-derived cells has been previously suggested. This study aimed to test the efficacy and safety of said cells through a multicenter, placebo-controlled study, to determine an appropriate cell dose, and to delineate the target patient population that can most benefit from cell therapy.

Methods: Patients experiencing FI for at least 6 months were randomized to receive a cell-free medium or low or high dose of cells.

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Introduction: The goal of this project was to create an up-to-date joint European clinical practice guideline for the diagnosis and treatment of faecal incontinence (FI), using the best available evidence. These guidelines are intended to help guide all medical professionals treating adult patients with FI (e.g.

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Article Synopsis
  • The study investigates the role of antioxidant enzyme gene expression in Crohn's disease (CD) by analyzing surgically removed intestinal tissues from 28 patients, focusing on both inflamed and normal areas.* -
  • Results showed significantly lower levels of SOD1 and GSR mRNA in inflamed tissues, suggesting a potential link between reduced antioxidant defenses and tissue damage in CD, while no significant differences were observed for other enzymes like SOD2 and GPX.* -
  • The findings indicate that antioxidant gene expression varies in CD, with decreased SOD1 and GSR possibly contributing to localized tissue injury from reactive oxygen species.*
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Anastomotic leakage is a serious postoperative complication following a low anterior resection of rectum. Current research in colorectal surgery focuses on searching for techniques which could minimize the risk of leakage. The main objective of this study was to evaluate the impact of cumulative fluid balance on microcirculatory changes at the anastomotic site.

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  • The study investigates a new method for predicting anastomotic leakage risk by monitoring levels of neopterin, tryptophan, and kynurenine in patients undergoing rectal resection for cancer.
  • Out of 42 patients, significant differences were found in urinary neopterin/creatinine ratios between those with and without complications, indicating a potential risk factor for leakage.
  • High preoperative levels of urinary neopterin may signal increased risk for anastomotic leakage, and abnormal neopterin levels in urine and drainage fluid could help identify this issue early in the recovery process.
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Background: The link between the blood count and a systemic inflammatory response (SIR) is indisputable and well described. Pretreatment hematological parameters may predict the overall clinical outcomes in many types of cancer. Thus, this study aims to systematically evaluate the relationship between baseline blood count levels and treatment response in rectal cancer patients treated with neoadjuvant chemoradiotherapy.

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Introduction: Laparoscopy is an increasingly used approach in the surgical treatment of rectal cancer and prostate cancer. The anatomical proximity of the two organs is the main reason to consider performing both procedures simultaneously.

Aim: To present our first experience of laparoscopic rectal resection and radical prostatectomy, performed simultaneously, in 3 patients.

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Background: The quality of a total mesorectal excision (TME) is one of the most important prognostic factors for local recurrence of rectal carcinoma. The aim of this study was to clarify the manner in which lesser pelvis dimensions affect the quality of TME via the transabdominal approach, while simultaneously defining the criteria for selecting patients most likely to have Grade 3 TME outcomes for a transanal approach using the TaTME technique.

Methods: An analysis from the registry was conducted using 93 of total 198 patients with rectal cancer of the mid- and lower third of the rectum who underwent: (1) a low anterior resection, (2) an ultra-low resection with coloanal anastomosis, or (3) an intersphincteric rectal resection, all with total mesorectal excision.

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  • The study compares laparoscopic and open surgical techniques for rectal cancer, focusing on circumferential resection margins and the quality of total mesorectal excision.
  • Data from 125 patients over three years revealed that complete mesorectal excision was more successful with laparoscopic methods (54.7%) compared to conventional methods (44.4%).
  • Ultimately, the findings suggest that laparoscopic surgery is equally effective as open surgery in terms of surgical outcomes, particularly regarding the completeness of the excision and minimizing positive circumferential margins.
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Herein we present a case of a 65-year-old woman with enterocolic lymphocytic phlebitis (ELP) who presented with anemic syndrome and in whom severe stenosis of the right flexure of large bowel was detected. The microscopic examination revealed fibrosis of the submucosa and lymphoplasmacytic phlebitis of small veins and venules, whereas arteries were spared. There were 110 IgG4-positive and 160 IgG-positive plasma cells in 1 high-power field, respectively, with corresponding IgG4/IgG ratio of 0.

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Background: This prospective study aimed to evaluate the impact of high-frequency ultrasound probe sonography (HFUPS) staging on the management of patients with superficial colorectal neoplasia (SCN) as determined by the endoscopic characteristics of lesions.

Methods: Consecutive patients referred for endoscopic treatment of nonpedunculated SCN were enrolled in this study. A lesion was considered high risk if a depressed area or invasive pit pattern was present.

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