Antidiarrheal activity of bark methanolic extract involves modulation ATPases in mice and inhibition of muscarinic acetylcholine receptor (M3) and prostaglandin E2 receptor 3 (EP) .

Objectives: Diarrhea, an abnormal state in which the individual has about three or more daily bowel movements, is now considered one of the most challenging global public health problems. Using plant products, such as is an alternative treatment option. The objective of this study was to investigate the antidiarrheal activity of bark methanolic extract (BfME) and the mechanisms involved.