Evaluation of the gastrointestinal anti-motility effect of stem bark extract: A mechanistic study of antidiarrheal activity.

Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It is a huge public health concern that requires better alternatives to current drugs. This study investigated the mechanisms involved in the antidiarrheal activity of (Ao) stem bark extract, a plant commonly used in the management of diarrhea in Nigeria.

Antidiarrheal activity of bark methanolic extract involves modulation ATPases in mice and inhibition of muscarinic acetylcholine receptor (M3) and prostaglandin E2 receptor 3 (EP) .

Objectives: Diarrhea, an abnormal state in which the individual has about three or more daily bowel movements, is now considered one of the most challenging global public health problems. Using plant products, such as is an alternative treatment option. The objective of this study was to investigate the antidiarrheal activity of bark methanolic extract (BfME) and the mechanisms involved.

Structure based design, stability study and synthesis of the dinitrophenylhydrazone derivative of the oxidation product of lanosterol as a potential transketolase inhibitor and in-vivo antimalarial study.

Unlabelled: The growing resistance to the current antimalarial drugs in the absence of a vaccine can be effectively tackled by identifying new metabolic pathways that are essential to the survival of the malaria parasite and developing new drugs against them. Triterpenes and steroids are the most abundant group of natural products with a great variety of biological activities. However, lanosterol is not known to possess any significant biological activity.