Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats.

Background: Humans are routinely exposed to bisphenol A (BPA), an estrogenic compound that leaches from dental materials, food and beverage containers, and other consumer products. Prenatal exposure to BPA has produced long-lasting and profound effects on rodent hormone-dependent tissues that are manifested 1-6 months after the end of exposure.

Objective: The aim of the present work was to examine whether in utero exposure to BPA alters mammary gland development and increases its susceptibility to the carcinogen N-nitroso-N-methylurea (NMU).

One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina.

Purpose: Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up.

Methods And Materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out.