Publications by authors named "Julio P Arroyo"
Article Synopsis
- A study explored the use of high-frequency irreversible electroporation (H-FIRE) as a new treatment for primary lung tumors in dogs, which is a less invasive method that destroys cancer cells by creating nanopores in their membranes.
- Five canine patients received H-FIRE treatment prior to surgical tumor removal, with results showing evidence of tumor ablation through histological analysis and specific staining techniques to identify cell death.
- The treatment was generally well tolerated, and initial findings indicate that H-FIRE may positively affect the tumor immune microenvironment and gene expression related to immunity.
The blood-brain barrier (BBB) limits the efficacy of treatments for malignant brain tumors, necessitating innovative approaches to breach the barrier. This study introduces burst sine wave electroporation (B-SWE) as a strategic modality for controlled BBB disruption without extensive tissue ablation and compares it against conventional pulsed square wave electroporation-based technologies such as high-frequency irreversible electroporation (H-FIRE). Using an rodent model, B-SWE and H-FIRE effects on BBB disruption, tissue ablation, and neuromuscular contractions are compared.
View Article and Find Full Text PDFThe 4th World Congress of Electroporation (Copenhagen, 9-13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harness electric fields to produce therapeutically useful effects on cancers and represent a valuable option for a variety of patients. As such, irreversible electroporation (IRE), gene electrotransfer (GET), electrochemotherapy (ECT), calcium electroporation (Ca-EP), and tumour-treating fields (TTF) are on the rise.
View Article and Find Full Text PDFThe treatment of CNS disorders suffers from the inability to deliver large therapeutic agents to the brain parenchyma due to protection from the blood-brain barrier (BBB). Herein, we investigated high-frequency pulsed electric field (HF-PEF) therapy of various pulse widths and interphase delays for BBB disruption while selectively minimizing cell ablation. Eighteen male Fisher rats underwent craniectomy procedures and two blunt-tipped electrodes were advanced into the brain for pulsing.
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