Cardiotrophin-1 administration protects from ischemia-reperfusion renal injury and inflammation.

Background: Ischemia-reperfusion injury (IRI) remains a major problem in renal transplantation, and the inflammatory response to IRI exacerbates the resultant renal injury. We have investigated whether the systemic administration of cardiotrophin-1 (CT-1) is able to improve renal function and to decrease inflammatory responses in a rat model of renal IRI.

Methods: IRI was induced by renal pedicle clamping (60 min) followed by reperfusion and contralateral nephrectomy.

Changes in pituitary and prolactin cells of Wistar rats after two dental fillings with bisphenolic resins.

Unlabelled: Bisphenol-A (BPA) is used to manufacture dental materials such as sealants, fillings and cements. There is evidence of its estrogenic effects on recipients after the placement of dental sealants. Pituitary and especially prolactin (PRL) cells are targets for estrogens.