Publications by authors named "Julio Henrique Ferreira de Sa Queiroz"
Syphilis is a significant public health concern worldwide. According to the 2020 estimates, nearly 7.1 million new cases of syphilis have been reported globally, with over 30 % of these cases reported from American nations, particularly Brazil.
View Article and Find Full Text PDFSyphilis remains a significant public health concern, with serological assays being the primary method for diagnosis. However, molecular techniques have proven to be reliable tools for the diagnosis and understanding of the transmission dynamics of Treponema pallidum infection. This study aimed to evaluate the efficacy of syphilis treatment using molecular assays, perform Enhanced Centers for Disease Control and Prevention (ECDC) typing, and analyze resistance (macrolide and doxycycline) in the T.
View Article and Find Full Text PDFArticle Synopsis
- Syphilis is a significant public health issue in Brazil, with limited data on the characteristics and resistance of the bacteria Treponema pallidum.
- The study aimed to detect Treponema DNA in lesions and blood samples from diagnosed syphilis patients, using PCR and RT-PCR methods.
- Results showed positive findings in several samples, with resistance to azithromycin identified in two cases, and new bacterial subtypes specific to Brazil were also documented for the first time.
Article Synopsis
- Syphilis is caused by the bacterium Treponema pallidum, and traditional diagnostic methods can vary in effectiveness based on the stage of infection and the type of test used.
- This study employed polymerase chain reaction (PCR) to detect T. pallidum DNA in blood samples, including those from patients with positive enzyme-linked immunosorbent assay (ELISA) results.
- Results showed that PCR could effectively identify T. pallidum, especially in latent-stage infections, and could serve as a complementary method to improve the overall diagnosis of syphilis.
Unlabelled: The incidence of syphilis has increased alarmingly over the years. Its diagnosis continues to be a challenge, leading to the search for new alternative and effective methods. The objective of this study was to select and evaluate three recombinant proteins for potential use in syphilis serodiagnosis.
View Article and Find Full Text PDFBlood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study.
EClinicalMedicine
March 2021
Background: There is a need to identify scalable tuberculosis screening strategies among high burden populations. The WHO has identified a non-sputum-based triage test as a development priority.
Methods: We performed a diagnostic case-control study of point-of-care C-reactive protein (CRP) and Prototype-Xpert-MTB-Host-Response (Xpert-MTB-HR) assays in the context of a mass screening program for tuberculosis in two prisons in Brazil.
Article Synopsis
- Syphilis is a major global health issue that can lead to severe outcomes like stillbirths, emphasizing the need for ongoing monitoring among women of reproductive age.
- A study in Dourados, Brazil, found a syphilis prevalence of 6.04% among women, with factors such as low income, lack of high school education, and a history of STIs linked to higher infection rates.
- Additionally, many women reported inconsistent condom use and multiple sexual partners, indicating a need for improved healthcare initiatives to promote regular screening and treatment compliance to reduce syphilis cases.
Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens.
PLoS One
September 2020
Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. To investigate the antibacterial activity of Cinnamomum cassia L. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens.
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- * Despite 96.5% of women receiving antenatal care, only 47.6% had the necessary tests in the first trimester, indicating gaps in healthcare services.
- * Risk factors linked to syphilis included illicit drug use and a history of abortion, suggesting that improving antenatal care and addressing social issues could help reduce syphilis rates in pregnant women.
Article Synopsis
- Syphilis cases in Brazil are rising, but there’s a lack of data on its prevalence among prisoners, prompting a study in Central-West Brazil involving 3,363 inmates.
- The findings revealed lifetime syphilis prevalence at 10.5% and active infection at 3.8%, with notable differences between genders; women showed higher rates than men.
- Risk factors for active syphilis varied between genders and included factors such as past sexually transmitted infections in men and drug use in women, highlighting the need for targeted awareness and screening programs in prisons, especially for female inmates.