Anticoagulant therapy in patients with congenital FXI deficiency.

The bleeding phenotype of factor XI (FXI) deficiency is unpredictable. Bleeding is usually mild and mostly occurs after injury. Although FXI deficiency renders antithrombotic protection, some patients might eventually develop thrombosis or atrial fibrillation, requiring anticoagulant therapy.

Gynaecological and obstetrical bleeding in Caucasian women with congenital factor XI deficiency: Results from a twenty-year, retrospective, observational study.

Introduction: Factor XI (FXI) deficiency is a mild bleeding disorder, common among Ashkenazis, that may be underestimated in Caucasians. Management of FXI deficiency in women is a challenge, due to its unpredictable bleeding tendency and the little evidence available on this issue.

Objective: To describe gynaecological/obstetrical bleeding complications and to analyze the effectiveness and safety of the antihaemorrhagic treatment among women with FXI deficiency.

Assessment of two contact activation reagents for the diagnosis of congenital factor XI deficiency.

Introduction: Congenital FXI deficiency, a coagulopathy associated with low bleeding risk but thrombotic protection, is usually diagnosed by prolonged APTT and confirmed by coagulation assays. Recent evidences suggest that FXI deficiency might be underestimated. Sensitive and reliable methods to detect FXI deficiency are required.

Sensitive and selective chromogenic sensing of carbon monoxide via reversible axial CO coordination in binuclear rhodium complexes.

The study of probes for CO sensing of a family of binuclear rhodium(II) compounds of general formula [Rh(2){(XC(6)H(3))P(XC(6)H(4))}(n)(O(2)CR)(4-n)]·L(2) containing one or two metalated phosphines (in a head-to-tail arrangement) and different axial ligands has been conducted. Chloroform solutions of these complexes underwent rapid color change, from purple to yellow, when air samples containing CO were bubbled through them. The binuclear rhodium complexes were also adsorbed on silica and used as colorimetric probes for "naked eye" CO detection in the gas phase.

Kinetico-mechanistic studies of the acidolysis of Rh-C bonds in monocyclometallated dirhodium(II) acetato complexes; influence of electronic and steric effects.

The protonation/demetallation reaction, in CD(3)COOD, of phosphine monometallated triacetato-bridged dirhodium(ii) complexes of general formulae [Rh(2)(μ-OOCCH(3))(3){(RC(5)CH(3))P(RC(6)H(4))(2)}(2)] has been studied from a kinetico-mechanistic perspective. The process has been monitored via the disappearance of the nuclear magnetic resonance signals of the protons present in the non-metallated ortho positions of the phosphine ligand and taking advantage of the relatively fast back metallation process that follows the acidolysis reaction, the sequence behaving as an overall equilibrium reaction. The process has a high associative character with important entropy demands, increasing both for the larger and the more electron withdrawing phosphine ligands.

Determination of equilibrium constants and computational interaction energies for adducts of [Rh2(RCO2)(4-n)(PC)n] (n = 0-2) with Lewis bases.

Properties of dirhodium catalysts with cyclometalated aryl phosphine ligands have been studied. We report here the study of the acid-base reaction of Rh2(RCO2)2(PC)2(H2O)2 catalysts (PC = cyclometalated aryl phosphine) with different Lewis bases. The determination of the equilibrium constants of these reactions can be used to study to which extent the properties of the axial coordination site of the catalyst, considered the active site, are affected by modification of the metalated phosphines, the carboxylate ligands, or the incoming axial ligand.

Isomerization processes on mixed ortho-metalated phosphine/succinimidato [Rh2(P(C5CH4)Ph2)2(OC4NH4O)2] complexes. A sliding movement of the succinimidato ligand.

An improved preparation of mixed ortho-metalated phosphine/succinimidato dirhodium(II) complexes, [Rh2(P(C5CH4)Ph2)2(OC4NH4O)2], allowed the isolation and characterization of a new isomeric form having both imidato N donors trans to P, 1', that adds up to the two already known having both, 1, or only one, 2, of the imidato N donors trans to the metalated C (Chart 3). The new complex, 1', isomerizes to the thermodynamically stable complex 2 similarly to what had already been observed for isomer 1. Stoichiometric and kineticomechanistic studies of both isomerization processes have been carried out.