Predicting cognitive function and dementia risk in patients with hypertension.

In spite of the fact that hypertension stand out as the main vascular risk factor for developing dementia, it is essential to acknowledge the presence of other risk factors, both vascular and non-vascular that contribute to increase this risk. This study stratified the dementia risk using CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) dementia risk score in a sample of 1279 hypertensive patients from the Heart-Brain Study in Argentina and to observed the association between the risk factors include in the CAIDE score and the current cognitive status. The average age of the sample was 60.

[Arterial Hypertension, Structural Damage of the Brain and Cognitive Test].

Introduction: The arterial hypertension cause brain vascular damage (white matter lesion) and the burden and progression determine their cognitive consequences. Therefore, arterial hypertension is considered the main modifiable vascular risk factor for cognitive impairment and dementia. Therefore, the aim of the current study was to evaluate the results of cognitive tests in a sample of hypertensive patients and to establish possible associations with structural brain lesions (atrophy, white matter lesions) identified by magnetic resonance imaging

Methods: Were included 70 hypertensive patients from Heart-Brain study in Argentina with magnetic resonance imaging and cognitive test.

[Psychometric properties and reliability of the general health questionnaire(GHQ-12) for adult patients in primary care centers in Cordoba, Argentina].

Introduction: The General Health Questionnaire (GHQ-12) is a commonly used instrument to screen for psychiatric distress. However, the psychometric properties and reliability of the GHQ-12 in Argentina and, more specifically, in the city of Cordoba, have not previously been studied.

Objective: To assess the psychometric properties and reliability of GHQ-12 in adult consultants of primary care in Cordoba, Argentina.

[The coverage gap for mental health disosrders in the primary healthcare level of the city of Cordoba, Argentina].

Unlabelled: Many individuals with behavioral and mental health disorders do not receive care in specialized mental health services. These individuals could potentially be identified and managed in the primary healthcare level.

Objective: To analyze the coverage gap on mental health disorders in the primary healthcare level of Córdoba city, Argentina.

[Prevalence of mental health disorders among patientswho attendeda service of neurology for chronic pain].

Unlabelled: The association between chronic pain and mental disorders is a determining factor of the disease evolution and requires a comprehensive approach in patients.

Objective: evaluate the prevalence of mental disorders in patients with chronic pain who use the service of Neurology at the National Clinical Hospital, Cordoba, Argentina.

Methodology: the study included patients with chronic pain who used the Neurology service, National Clinical Hospital in Cordoba, Argentina, selected from a validated form that contains the appropriate clinical criteria.

[Psychological evaluations of operation of patients with mental disorders].

Unlabelled: The severe and chronic mental illnesses such as schizophrenia are associated with very complex problems that are not confined to the symptoms but also affect psychosocial functioning and community integration.

Objective: To evaluate the reliability (in terms of internal consistency) of the WHODAS 2.0 for analyzing the psychosocial functioning of people with schizophrenia living in the community and using mental health services, and report the WHODAS 2.

[Screening for posttraumatic stress disorder in people affected by the 2010 earthquake in Chile.].

The authors conducted an assessment of post-traumatic stress disorder screening in the Chilean population following the February 2010 earthquake, based on the Post Earthquake Survey with a multistage sample of 24,982 individuals over 18 years of age, applying the Davidson Trauma Scale. Multivariate analysis was performed with significance set at p<0.05.

Relationship between academic performance, psychological well-being, and coping strategies in medical students.

Introduction: Academic performance is a product of the complex environment that surrounds the student, shaped by aspects such as intensity of study, motivation and context of relationships, which affect the academic achievement of individuals. There may be other psychological or emotional factors, such as anxiety, level of psychological well-being, and behavior strategies for effective adaptation to concrete environment demands and their associated emotional stress.

Objectives: This research study aims at determining the level of psychological well-being and coping strategies in students of the Basic Common Cycle of studies leading to an MD degree in the School of Medicine of the National University of Córdoba, Argentina.

Cognition and vascular risk factors: an epidemiological study.

We conducted an epidemiological approach to identify the negative impact of the vascular risk factors (such as hypertension, diabetes and hypercholesterolemia) over cognition. The interesting aspect of this study was that the survey was conducted in all age groups through a voluntary call (n = 1365; ≥18 years old, both sexes; age 49 ± 15 y, female 75.7%).

[Analysis of the frequency of experimentation with and consumption of drugs in high-school students].

The aim of this study was to survey the frequency of experimentation and consumption of drugs in high-school students in Cordoba, Argentina, relating it to socio-demographic variables. An observational-analytical method was employed, on the basis of the records of the Secretary for the Planning of Drug-Addiction Prevention and Fighting of Drug-Trafficking. Statistical.

Association of clomipramine and allopurinol for the treatment of the experimental infection with Trypanosoma cruzi.

We have previously shown that clomipramine and allopurinol used separately are effective in preventing chronic chagasic cardiomyopathy. The aim of the present study was to evaluate the effect of the association of clomipramine (Clo--5 mg/kg/day/90 days) and allopurinol (Allo--5, 10, or 15 mg/kg/day/90 days) for the treatment of experimental Chagas disease in the acute stage. Treatment effectiveness was evaluated through parasitemia, survival, electrocardiography, serology, and cardiac histopathology.

Some components of the cardiac β-adrenergic system are altered in the chronic indeterminate form of experimental Trypanosoma cruzi infection.

The chronic indeterminate form of Trypanosoma cruzi infection could be the key to knowing which patients will develop chagasic myocardiopathy. Infected mice present a period in which cardiac functional and structural alterations are different from those described for acute or chronic phases. We studied some components of the cardiac β-adrenergic system in mouse hearts infected with T.

Chemotherapy of chronic indeterminate Chagas disease: a novel approach to treatment.

Treatment of Chagas disease is a controversial issue because the available drugs are highly toxic. Clomipramine is a tricyclic antidepressant drug that inhibits Trypanosoma cruzi's trypanothione reductase, provoking the death of the parasite and preventing the cardiac damage when used for the treatment of acutely infected mice. Here, we studied the effectiveness of clomipramine (5 mg/kg/day for one month) as chemotherapy for T.

[Scores to predict the number of hospitalization days in a general ward at a tertiary hospital].

Unlabelled: Although most usual admissions to hospital are in rooms in general wards, there are not scores to predict the number of hospitalization days in this area. The patients are located based on diagnosis at admission.

Aim: to make scores who predict the number of hospitalization days in the general wards.

Allopurinol is effective to modify the evolution of Trypanosoma cruzi infection in mice.

There is a real need for new and less toxic drugs for the treatment of Chagas disease, as nifurtimox and benznidazole are effective but toxic and provoke unpleasant side effects, especially in adult patients. Allopurinol, commonly used to treat the hiperuricemia, is also used by the Trypanosoma cruzi's hypoxantine guanine fosforyltransferase as an alternative substrate incorporating it into the parasite's ribonucleic acid, provoking the death of the parasite. However, the results of using allopurinol as chemotherapy for Chagas disease are not clear.

Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.

Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate were treated at 180 days post infection (p.i.) (i.

Reinfections and Trypanosoma cruzi strains can determine the prognosis of the chronic chagasic cardiopathy in mice.

Chronic Chagas' disease represents the result of the interaction between the host and the parasite, producing different clinical features: from a mild disease to a severe heart failure. In the present investigation, we analyzed whether Trypanosoma cruzi strain and/or reinfections in the acute stage, determine changes in the chronic phase (135 days postinfection, d.p.

Changes in the cardiac beta-adrenergic system provoked by different T. cruzi strains.

Background: It has been demonstrated that the beta-adrenergic signal transduction system is altered somewhere along its pathway in Trypanosoma cruzi infected hearts and we think that these alterations would differ according to the infection phase and the parasite strain. Their study would be important for the understanding of the disease's pathophysiology.

Methods: In the present work we studied important components of this system in mice hearts infected with T.

Studies of membrane fluidity and heart contractile force in Trypanosoma cruzi infected mice.

In Chagas disease serious cardiac dysfunction can appear. We specifically studied the cardiac function by evaluating: ventricle contractile force and norepinephrine response, affinity and density of beta-adrenergic receptors, dynamic properties of myocardial membranes, and electrocardiography. Albino swiss mice (n = 250) were infected with 55 trypomastigotes, Tulahuen strain and studied at 35, 75, and 180 days post-infection, that correspond to the acute, indeterminate, and chronic phase respectively.

Trypanosoma cruzi reinfections provoke synergistic effect and cardiac beta-adrenergic receptors' dysfunction in the acute phase of experimental Chagas' disease.

Cardiac beta-adrenergic receptors' function was studied in the acute phase of Chagas' disease in mice reinfected with Trypanosoma cruzi Tulahuen strain (Tul) and with parasites isolated from an infected patient (SGO-Z12). Genetic characterization of SGO-Z12 isolates demonstrated that it belongs to the zimodeme Z12, one of the prevalent ones in humans in Argentina. Electrocardiography, heart histopathology, parasitemias, and survival in infected and reinfected mice were also analyzed.

Indeterminate Chagas' disease: Trypanosoma cruzi strain and re-infection are factors involved in the progression of cardiopathy.

Chagas' disease is caused by Trypanosoma cruzi, which is transmitted by reduviid bugs. The World Health Organization has estimated that about 16-18 million people in the Americas are infected, and that more than 100 million are at risk. In the present study we have used a murine model to analyse if particular T.