Optical coherence tomography of the retina and optic nerve - a review.

Optical coherence tomography (OCT) is a rapid non-contact method that allows in vivo imaging of the retina, optic nerve head and retinal nerve fibre layer (RNFL). Since its introduction in Ophthalmology approximately a decade ago, the use of this technology has disseminated into the clinical practice. OCT has proven to be a useful ancillary tool for assessing retinal diseases because of its capability to provide cross-sectional images of the retina, and also to perform quantitative analysis of retinal morphology.

Detecting visual function abnormalities using the Swedish interactive threshold algorithm and matrix perimetry in eyes with glaucomatous appearance of the optic disc.

Objective: To compare the ability of 24-2 frequency-doubling perimetry (FDP-Matrix) with standard automated perimetry with the Swedish interactive threshold algorithm (SAP-SITA) in detection of visual function abnormalities in patients with glaucomatous-appearing optic discs (GAOD).

Methods: This observational case-control study included 80 patients with GAOD and 54 control subjects diagnosed by masked assessment of optic disc stereoscopic photographs. Abnormal visual function at SAP-SITA and FDP-Matrix testing required consistent abnormalities in 2 visual field examinations, determined using the glaucoma hemifield test outside 99% normal limits, pattern standard deviation outside 95% normal limits, or 3 contiguous points in the pattern deviation probability plot outside 95% normal limits (at least 1 P<1%) within the same hemifield.

Effect of glaucomatous damage on repeatability of confocal scanning laser ophthalmoscope, scanning laser polarimetry, and optical coherence tomography.

Purpose: To determine and compare the effect of the severity of glaucomatous damage on the repeatability of retinal nerve fiber layer (RNFL) thickness with GDx-VCC (variable corneal compensation) and StratusOCT (optical coherence tomography; both produced by Carl Zeiss Meditec, Inc., Dublin, CA), and optic nerve head (ONH) topography with HRT-II (retinal tomograph; Heidelberg Engineering GmbH, Heidelberg, Germany) and StratusOCT.

Methods: With each of these techniques, two measurements were obtained from 41 eyes of 41 control subjects and 98 glaucomatous eyes (37 patients with early, 29 with moderate, and 32 with severe field loss).

Selective perimetry in glaucoma diagnosis.

Purpose Of Review: Selective perimetry evaluates visual function by using visual stimuli that attempt to target specific subpopulations of retinal ganglion cells, which is designed to improve sensitivity to detect glaucomatous functional loss. This paper reviews recent studies that have assessed the characteristics of new strategies/programs of selective perimetry.

Recent Findings: Selective perimetry is usually compared against an existing standard technique--standard automated perimetry.

Correlations between retinal nerve fiber layer and visual field in eyes with nonarteritic anterior ischemic optic neuropathy.

Purpose: To evaluate correlations between retinal nerve fiber layer (RNFL) thickness with visual field (VF) sensitivities in eyes with nonartertic anterior ischemic optic neuropathy (NAION).

Design: Case-control study in an academic, institutional setting.

Methods: One eye from 21 patients with NAION and 32 healthy participants were included in this prospective study.

Comparison of the Moorfields classification using confocal scanning laser ophthalmoscopy and subjective optic disc classification in detecting glaucoma in blacks and whites.

Objective: To compare the diagnostic accuracy of the Moorfields regression classification (MRC) and subjective optic disc evaluation in discriminating early to moderate glaucomatous from nonglaucomatous eyes.

Design: Cross-sectional observational study.

Participants: Two hundred thirty-three patients with glaucoma and 216 normal subjects were included in the analysis.

Long ciliary processes with no ciliary sulcus and appositional angle closure assessed by ultrasound biomicroscopy.

Purpose: Nonpupil block mechanisms and appositional angle closure after laser iridotomy (LI) have been reported as common findings in Asians. We evaluated the presence of these findings in a cohort of Brazilian patients using ultrasound biomicroscopy (UBM).

Methods: This observational case-control study included 22 open angle eyes and 31 eyes with occludable angles on gonioscopy (defined by 2 examiners).

Discrimination between glaucomatous and nonglaucomatous eyes using quantitative imaging devices and subjective optic nerve head assessment.

Purpose: To compare the diagnostic ability of the confocal scanning laser ophthalmoscope (HRT-II; Heidelberg Engineering, Heidelberg, Germany), scanning laser polarimeter (GDx-VCC; Carl Zeiss Meditec, Inc., Dublin, CA), and optical coherence tomographer (StratusOCT, Carl Zeiss Meditec, Inc.) with subjective assessment of optic nerve head (ONH) stereophotographs in discriminating glaucomatous from nonglaucomatous eyes.

Differences in optic disc topography between black and white normal subjects.

Purpose: To determine if differences in optic disc topography exist between blacks and whites independent of racial differences in the area of the scleral canal.

Design: Cross-sectional observational study.

Participants: A cohort of 146 eyes from black subjects and 97 eyes from white subjects without detectable ocular disease.

Subjective and objective optic nerve assessment in African Americans and whites.

Objective: To compare the ability of quantitative optic disc topography and subjective optic disc evaluation to discriminate early glaucomatous from normal eyes in African Americans and whites.

Methods: Monocular data from eyes of 88 African-American patients and 63 eyes of white patients with glaucoma were included in the analysis. Sixty-three eyes of African American normal subjects and 42 eyes of white normal subjects were used as a control group.

Racial differences in the association between optic disc topography and early glaucoma.

Purpose: To determine the structural characteristics of the optic disc that are associated with early glaucoma in African Americans and whites and whether these characteristics differ between the races.

Methods: Parameters of optic disc topography from 260 African American eyes and 193 white eyes were included in the analysis. One hundred forty-four eyes of African Americans and 109 eyes of normal white subjects were used as a control group.