Publications by authors named "Julio Chirinos-Pacheco"
Background: Chronic Kidney Disease (CKD) represents a great burden for the patient and the health system, particularly if diagnosed at late stages. Consequently, tools to identify patients at high risk of having CKD are needed, particularly in limited-resources settings where laboratory facilities are scarce. This study aimed to develop a risk score for prevalent undiagnosed CKD using data from four settings in Peru: a complete risk score including all associated risk factors and another excluding laboratory-based variables.
View Article and Find Full Text PDFNormative values and correlates of carotid artery intima-media thickness and carotid atherosclerosis in Andean-Hispanics: The Prevencion Study.
Atherosclerosis
August 2010
Objectives: Carotid intima-media thickness (cIMT) is an independent predictor of cardiovascular risk. Furthermore, ethnicity and gender-specific normative data are required to assess cIMT, which are not available for Andean-Hispanics. In addition, data regarding correlates of subclinical atherosclerosis in ethnic population are needed.
View Article and Find Full Text PDFObjective: We aimed to establish optimal definitions for abdominal obesity and metabolic syndrome (MetS) among Andean adults.
Research Design And Methods: Among 1,448 Andean adults, we assessed the relationship between waist circumference and subclinical vascular disease assessed by carotid intima-media thickness (cIMT) and manifest cardiovascular disease (M-CVD).
Results: Optimal waist circumference cutoffs to classify individuals with abnormal cIMT or M-CVD were >97 and >87 cm in men and women, respectively.
Endogenous NO synthase inhibitors (end-NOSIs) have been associated with cardiovascular risk factors and atherosclerosis. In addition, end-NOSIs may directly cause hypertension through hemodynamic effects. We aimed to examine the association between end-NOSI asymmetrical dimethylarginine (ADMA) and N-guanidino-monomethyl-arginine (NMMA), subclinical atherosclerosis, and arterial hemodynamics.
View Article and Find Full Text PDFArticle Synopsis
- * Among women, low HDL cholesterol and abdominal obesity were the most common MTS components, while men mostly had elevated triglycerides and low HDL cholesterol.
- * The overall prevalence of MTS was higher in women (23.2%) than in men (14.3%), especially increasing with age, indicating a need for further research on underlying causes specific to this population.
Article Synopsis
- Cardiovascular disease is becoming increasingly prevalent in Latin America, with a study of 1,878 Andean adults in Peru revealing a hypertension prevalence of 15.7%, which rises sharply with age, especially among women.
- Awareness, treatment, and control of hypertension were low, with only 47.9% of patients aware of their condition, 39.5% receiving treatment, and a mere 14% achieving effective control.
- The study found that the most common type of hypertension in this population was systodiastolic (41.7%), differing from the U.S. where isolated systolic hypertension is more prevalent, indicating unique genetic and environmental factors influencing hypertension in Andean communities.
Latin America is undergoing the epidemiologic transition that occurred earlier in developed countries, and is likely to face a gigantic epidemic of heart disease in the next few years unless urgent action is taken. The first essential component of any effective cardiovascular disease (CVD) control program is to establish reliable estimates of cardiovascular disease-related morbidity and mortality. However, such data from population-based studies in Latin America are still lacking.
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