Increase in collagen turnover induced by intradermal injection of carbon dioxide in rats.

Introduction: Results from clinical observations have demonstrated that percutaneous infiltration of carbon dioxide improves the appearance of the skin in adjacent areas. No studies have been found in the literature that showed evidence of histological changes caused by carbon dioxide injections.

Objectives And Methods: A blind cross-sectional pilot study was performed in the Departments of Pharmacology and Morphology of the Federal University of Ceará, with the aim of histologically investigating whether intradermal and/or subcutaneous injection of medicinal carbon dioxide would increase collagen turnover in rats.