Biological characteristics of age-related changes in C57BL/6 mice sub-strains in the National Center for Geriatrics and Gerontology Aging Farm.

Aging is a complex biological process. Several animal models, including nematodes, Drosophila, and rodents, have been used in research on aging mechanisms and the extension of healthy life expectancy. The present study investigated the physiological and anatomical changes associated with aging in two sub-strains of aged C57BL/6 mice used in aging research: C57Bl/6NCrSlc (B6N) and C57BL/6J (B6J).

Hematological and biochemical characterization of aging farm male rat strains in the national center for geriatrics and gerontology.

Laboratory rats, like mice, are a type of animal commonly used in scientific investigations as well as in basic aging and geriatric research. The selection of a rat strain is an important first step in the planning and design of an experiment due to physiological, anatomical, and ethological variations in each strain, which may significantly modify the expected results. In the present study, we characterized age-related changes, from 3 months old (mo) to 24 mo, in three male rat strains commonly used in medical research: RccHan:WIST (RccHan:WIST), F344/NSlc (F344), and Slc:SD Rat (SD).

Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion.

Aging progresses through the interaction of metabolic processes, including changes in the immune and endocrine systems. Glucocorticoids (GCs), which are regulated by the hypothalamic-pituitary-adrenal (HPA) axis, play an important role in regulating metabolism and immune responses. However, the age-related changes in the secretion mechanisms of GCs remain elusive.