Publications by authors named "Juliette Gouhier"
Nuclear positioning is a crucial aspect of cell and developmental biology. One example is the apical movement of nuclei in neuroepithelia before mitosis, which is essential for proper tissue formation. While the cytoskeletal mechanisms that drive nuclei to the apical side have been explored, the influence of nuclear properties on apical nuclear migration is less understood.
View Article and Find Full Text PDFNa-K-2Cl cotransporter 1 (NKCC1) regulates chloride influx in neurons and thereby GABA receptor activity in normal and pathological conditions. Here, we characterized in hippocampal neurons the membrane expression, distribution and dynamics of exogenous NKCC1a and NKCC1b isoforms and compared them to those of the chloride extruder K-Cl cotransporter 2 (KCC2). We found that NKCC1a and NKCC1b behave quite similarly.
View Article and Find Full Text PDFArticle Synopsis
- - The upregulation of the NKCC1 cotransporter in mature neurons can cause excitatory responses through GABA receptors, which may contribute to hyperactivity and certain neurological disorders.
- - Research shows that GABAergic activity influences NKCC1's behavior in neurons through a pathway involving WNK1 and SPAK, which can lead to increased chloride levels during hyperactivity.
- - The WNK1 pathway also regulates KCC2, the main chloride exporter, suggesting its potential as a target for therapeutic interventions in conditions with disrupted chloride balance.