Publications by authors named "Juliette Gair"

Objective: Management of vestibular schwannomas (VS) involves surgery, radiotherapy, or surveillance, based on patient and tumor factors. We recently described conditional probability as a more accurate method for stratifying VS growth risk. Building on this, we now describe determinants of VS growth, allowing clinicians to move toward a more personalized approach to growth-risk profiling.

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Objective: To assess the complication rate of magnetic resonance imaging (MRI) using 1.5 T scanners on cochlear implant (CI) and auditory brainstem implant (ABI) recipients over 14.5 years.

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Objective: The natural history of vestibular schwannomas (VS) is well documented in the literature, with tumour growth being paramount to decision making for both surveillance and treatment of these patients. Most previous studies refer to the risk of VS growth over a given period of time; however, this is not useful for counselling patients at different stages of their follow-up, as the risk of tumour growth is likely to be less following each subsequent year that a tumour does not grow. Accordingly, we investigated the conditional probability of VS growth at particular time-points, given a patient has not grown thus far.

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 Observation is a well-accepted management for small- to medium-sized vestibular schwannomas (VSs). Although there are good data on the natural history of this disease within adults, no studies have looked specifically at those aged over 70 years. Thus, there is a need for a surveillance protocol to determine if and when we can stop imaging safely patients aged 70 years and over with a new diagnosis of VSs when managed with observation.

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Article Synopsis
  • The study evaluates the occurrence of mosaicism in de novo neurofibromatosis 2 (NF2) among patients without known prior family history, testing over 1,000 individuals for NF2 variants using DNA from lymphocytes and tumors.
  • The findings show that 22% of patients exhibited proven or presumed mosaic NF2 variants, with the overall probable mosaicism rate estimated at nearly 60%, varying significantly with age.
  • The research concludes that NF2 likely has the highest mosaicism rate in nonlethal de novo dominant diseases, suggesting minimal risks to offspring that may be related to the variant frequencies found in the parents' blood.
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Article Synopsis
  • The study identifies deficiencies in the current diagnostic criteria for neurofibromatosis 2 (NF2) by analyzing two large patient databases.
  • Evidence suggests that terms like "glioma" and "neurofibroma" should be eliminated from the criteria, as they do not effectively contribute to diagnoses.
  • The term "ependymoma” showed a 100% positive predictive value, while individuals over 60 with bilateral vestibular schwannomas had low confirmation rates, indicating a need for updated criteria and genetic testing recommendations.
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