Publications by authors named "Juliette A Morris"
Background: Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor. Most DIPGs harbor a histone H3 mutation, which alters histone post-translational modification (PTM) states and transcription. Here, we employed quantitative proteomic analysis to elucidate the impact of the H3.
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- Histone post-translational modifications (PTMs), like acetylation and methylation, help regulate access to genetic information and maintain chromosomal integrity, which is important for cell function and linked to various diseases.
- Traditional methods for studying histones require a large number of cells (usually over a million), making it hard to analyze rare cell types and their specific histone PTMs.
- A new LC-MS/MS method was developed that allows for the detection and quantification of histone PTMs using as few as 1,000 cells, enabling researchers to study rare cell populations and improve understanding of their role in diseases like acute myeloid leukemia.*