Publications by authors named "Julieta Fernandez Ruocco"
Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However, diabetic patients have higher risk of ventricular arrhythmia and sudden cardiac death, and metformin failed to reduce ventricular arrhythmia in clinical trials. In order to explore the mechanisms responsible for the lack of protective effect, we investigated in vivo the effect of metformin on cardiac electrical activity in non-diabetic rats; and in vitro in isolated ventricular myocytes, HEK293 cells expressing the hERG channel and human induced pluripotent stem cells derived cardiomyocytes (hIPS-CMs).
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- - Hypothyroidism causes changes in heart electrical activity that can lead to dangerous heart rhythms (arrhythmias), particularly influenced by high levels of thyrotropin (TSH), which is linked to worse health outcomes.
- - Researchers created two rat models to study the effects of low and high TSH levels on the heart, using methods like electrocardiograms and measuring ionic currents in heart cells.
- - While both hypothyroidism models showed increased calcium currents, only the primary hypothyroidism model (high TSH) had notable heart rhythm issues; TSH treatment also altered heart cell activity and decreased important potassium currents in myocytes.
Hemodynamic collapse and myocardial dysfunction are among the major causes of death in severe sepsis. The purpose of this study was to assess the role played by toll-like receptor 4 and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after high-grade polymicrobial sepsis. We performed the colon ascendens stent peritonitis (CASP) surgery in Tlr4, Nlrp3, and caspase-1 mice.
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