Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption.

Drug absorption across viable porcine intestines was investigated using an Ussing chamber system. The apparent permeability coefficients, , were compared to the permeability coefficients determined in humans in vivo, . Eleven drugs from the different Biopharmaceutical Classification System (BCS) categories absorbed by passive diffusion with published values were used to test the system.