Ceratohyoidectomy in standing sedated horses.

Objective: To investigate the feasibility and complications associated with ceratohyoidectomy (CHE) in standing sedated horses unaffected (experimental horses) and standing sedated horses affected (clinical cases) with temporohyoid osteoarthropathy (THO).

Study Design: Case series.

Animals: Six experimental horses and four clinical cases.

Complications associated with closed castration using the Henderson equine castration instrument in 300 standing equids.

Objective: To describe a closed castration technique in standing equids, report associated complications, and identify potential risk factors.

Study Design: Prospective cohort study of 300 standing equids that were castrated with the Henderson Equine Castrating Instrument.

Methods: Thirteen participating veterinarians recorded intraoperative difficulties and postoperative complications.

Methylenecyclopropene: local vision of the first B excited state.

The A ground and the first B excited states of the methylenecyclopropene (triafulvene) are described by localized wave functions, based on 20 structures valence bond structures. The results are compared to CASSCF(4,4) calculations for both the energetics and the dipole moment. Additional calculations with partial electronic delocalization are presented, and it is shown that the dipole moment modification does not correspond to a situation where the antiaromatic situation prevails (with 4n electrons in the cycle).

Recasting wave functions into valence bond structures: A simple projection method to describe excited states.

A method is proposed to obtain coefficients and weights of valence bond (VB) determinants from multi configurational wave functions. This reading of the wave functions can apply to ground states as well as excited states. The method is based on projection operators.

Large hyperconjugation in strained systems.

Carbocations can appear as transient species, for instance, in elimination reactions and various rearrangements. Hyperconjugation (or conjugation) can then stabilize the cationic character and form a partial π bond. The effect of the electronic delocalization from strained substituents to a carbocation part was calculated.

Clinical and molecular characterization of the potential CF disease modifier syntaxin 1A.

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator gene (CFTR). Disease severity in CF varies greatly, and sibling studies strongly indicate that genes other than CFTR modify disease outcome. Syntaxin 1A (STX1A) has been reported as a negative regulator of CFTR and other ion channels.

Comparison of genomic and proteomic data in recurrent airway obstruction affected horses using Ingenuity Pathway Analysis®.

Background: Recurrent airway obstruction (RAO) is a severe chronic respiratory disease affecting horses worldwide, though mostly in the Northern hemisphere. Environmental as well as genetic factors strongly influence the course and prognosis of the disease. Research has been focused on characterization of immunologic factors contributing to inflammatory responses, on genetic linkage analysis, and, more recently, on proteomic analysis of airway secretions from affected horses.