Publications by authors named "Julien Le Guen"
Article Synopsis
- Researchers conducted a study on patients aged 70 and older to evaluate the occurrence of local complications from peripheral venous catheters, focusing on risk factors and their impact on patient outcomes.
- The study involved monitoring 322 patients in a French hospital, revealing an incidence rate of complications at 50.5 per 1000 catheter-days, with factors like dressing replacement and specific medications increasing the risk.
- Findings indicated that complications led to longer hospital stays, suggesting the need for careful clinical monitoring to improve patient care for this age group.
Article Synopsis
- Percutaneous left atrial appendage closure is aimed at patients with atrial fibrillation who are at high risk for blood clots and bleeding, and this study evaluates its effectiveness and safety in a French medical center from 2014 to 2020.
- The study involved 207 patients, achieving a successful closure rate of 97.6%, while noting a decline in procedural complications over the years and a significant reduction in both thromboembolic and bleeding events during follow-up.
- The findings highlight the procedure's benefits and the importance of collaborative medical expertise to ensure successful outcomes in this high-risk patient population.*
Background: Although a growing number of very elderly patients with atrial fibrillation (AF), multiple conditions, and polypharmacy receive direct oral anticoagulants (DOACs), few studies specifically investigated both apixaban/rivaroxaban pharmacokinetics and pharmacodynamics in such patients.
Aims: To investigate: (1) DOAC concentration-time profiles; (2) thrombin generation (TG); and (3) clinical outcomes 6 months after inclusion in very elderly AF in-patients receiving rivaroxaban or apixaban.
Methods: Adage-NCT02464488 was an academic prospective exploratory multicenter study, enrolling AF in-patients aged ≥80 years, receiving DOAC for at least 4 days.
The relationship with death has evolved. Funeral rites are becoming less common, while deaths in hospital are more frequent. This societal evolution has led the hospital and the nursing staff to have to adapt and organize themselves to better support patients at the end of life and their families.
View Article and Find Full Text PDFVenous thromboembolism during systemic inflammatory and autoimmune diseases associated with myelodysplastic syndromes, chronic myelomonocytic leukaemia and myelodysplastic/myeloproliferative neoplasms: a French multicentre retrospective case-control study.
Clin Exp Rheumatol
July 2022
Objectives: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukaemia (CMML) are associated with systemic inflammatory and autoimmune diseases (SIADs) in 10-30% of cases. The aims of this study were (i) to evaluate the prevalence of venous thromboembolism VTE in patients presenting with both MDS/CMML and SIADs, (ii) to describe risk factors associated with thrombosis, and (iii) to analyse the impact of VTE on overall survival and transformation to acute myeloid leukaemia in comparison to patients with MDS/CMML-associated SIADs without VTE.
Methods: This retrospective multicentre case-control study was conducted among patients with MDS/CMML and dysimmune disorders and featured in the French retrospective database of the French Network of Dysimmune Disorders Associated with Hemopathies (MINHEMON), diagnosed with MDS/CMML and dysimmune disorders.
Aims: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with various causes that may influence prognosis.
Methods And Results: We extracted the electronic medical records for 2180 consecutive patients hospitalized between 2016 and 2019 for decompensated heart failure. Using a text mining algorithm looking for a left ventricular ejection fraction ≥50% and plasma brain natriuretic peptide level >100 pg/mL, we identified 928 HFpEF patients.
The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unexplained. Here, we uncovered an unexpected role for glomerular endothelial cells during aging.
View Article and Find Full Text PDFThe SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India.
View Article and Find Full Text PDFBackground: demand for intensive care of the very elderly is growing, but few studies report inclusion of their opinions in the admission decision-making process. Whether or not to refer a very elderly patient to intensive care unit is a difficult decision that should take into account individual wishes, out of respect for the patient's decision-making autonomy.
Methods: in 15 emergency departments, patients over 80 years old who had a potential indication for admission to intensive care, and that were capable of expressing their opinion were included.
How Drug Use by French Elderly Patients Has Changed During the Last Decade.
Drugs Real World Outcomes
October 2015
Background: In France the most recent data on drug use by the elderly living at home were published in 2000. Since then the available drugs and their use have changed.
Objective: We compared data collected in 2011 with the 2000 data to evaluate how drug use has changed in France.
Objective: To evaluate the efficacy compared to the relapse risk and tolerance of systematic rituximab (RTX) infusions as maintenance therapy for patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), who entered remission taking conventional immunosuppressants or RTX.
Methods: A retrospective study of the main clinical characteristics, outcomes, and RTX tolerance of patients who had received ≥ 2 RTX maintenance infusions in our center, regardless of induction regimen, between 2003 and 2010.
Results: We identified 28 patients [4 MPA and 24 GPA; median age 55.