Publications by authors named "Julien L P Morival"
Article Synopsis
- Aberrations in nuclear size and shape can indicate cancer, but it's unclear if these changes directly cause cancer or are a side effect of tumor development.
- The study finds that invasive breast cancer cells often have lower levels of lamin A/C, a nuclear envelope protein, driven by Akt signaling, which makes their nuclei more deformable and enhances their ability to migrate, similar to conditions during metastasis.
- In human breast tumors, lower lamin A levels were linked to increased Akt activity and worse survival rates, suggesting that the reduction of lamin A/C may enhance both the physical and biochemical properties of cancer cells to promote metastasis.
DNA methylation is a well-characterized epigenetic modification involved in numerous molecular and cellular functions. Methylation patterns have also been associated with aging mechanisms. However, how DNA methylation patterns change within key brain regions involved in memory formation in an age- and sex-specific manner remains unclear.
View Article and Find Full Text PDFBackground: Mutations in LMNA, encoding lamin A/C, lead to a variety of diseases known as laminopathies including dilated cardiomyopathy (DCM) and skeletal abnormalities. Though previous studies have investigated the dysregulation of gene expression in cells from patients with DCM, the role of epigenetic (gene regulatory) mechanisms, such as DNA methylation, has not been thoroughly investigated. Furthermore, the impact of family-specific LMNA mutations on DNA methylation is unknown.
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